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REFERENCES BIBLIOGRAPHIQUESwhi<strong>le</strong> maintaining normal hepatic sphinganine/sphingosine ratios. Journal of Agricultural andFood Chemistry, 49, 4113-4121.LOISEAU, N., DEBRAUWER, L., SAMBOU, T., BOUHET, S., MILLER, J. D., MARTIN, P. G., VIADERE, J. L.,PINTON, P., PUEL, O., PINEAU, T., TULLIEZ, J., GALTIER, P. & OSWALD, I. P. 2007. Fumonisin B-1 exposure and its se<strong>le</strong>ctive effect on porcine jej<strong>un</strong>al segm<strong>en</strong>t: Sphingolipids, gly<strong>co</strong>lipids andtrans-epithelial passage disturbance. Biochemical Pharma<strong>co</strong>logy, 74, 144-152.LOPEZ-GARCIA, R., PARK, D. L. & PHILLIPS, T. D. 1999. Integrated My<strong>co</strong>toxin Managem<strong>en</strong>t Systems.Food, Nutrition and Agriculture, 23, 38-48.LU, Z., DANTZER, W. R., HOPMANS, E. C., PRISK, V., CUNNICK, J. E., MURPHY, P. A. & HENDRICH, S.1997. Reaction with fructose detoxifies fumonisin B-1 whi<strong>le</strong> stimulating liver-associatednatural kil<strong>le</strong>r cell activity in rats. Journal of Agricultural and Food Chemistry, 45, 803-809.MMADHESWARAN, R., BALACHANDRAN, C. & MANOHAR, B. M. 2004. Influ<strong>en</strong>ce of dietary culturematerial <strong>co</strong>ntaining aflatoxin and T-2 toxin on certain serum biochemical <strong>co</strong>nstitu<strong>en</strong>ts inJapanese quail. My<strong>co</strong>pathologia, 158, 337-341.MADHESWARAN, R., BALACHANDRAN, C. & MANOHAR, B. M. 2005. Effect of feeding aflatoxin and T-2 toxin on the growth rate and haematology of Japanese quail. Indian Veterinary Journal, 82,597-600.MADHESWARAN, R., BALACHANDRAN, C., MANOHAR, B. M., VAIRAMUTHU, S. & CHANDRAMOHAN,A. 2006. Ultrastructural changes in liver of Japanese quail fed aflatoxin and T-2 toxin. IndianVeterinary Journal, 83, 1125-1126.MADHYASTHA, M. S., FROHLICH, A. A. & MARQUARDT, R. R. 1992. Effect of Dietary Cho<strong>le</strong>styramineon the Elimination Pattern of Ochratoxin-a in Rats. Food and Chemical Toxi<strong>co</strong>logy, 30, 709-714.MADSEN, A., HALD, B. & MORTENSEN, H. P. 1983. Feeding Experim<strong>en</strong>ts with Ochratoxin-aContaminated Bar<strong>le</strong>y for Ba<strong>co</strong>n Pigs .3. Detoxification by Ammoniation Heating + Naoh, orAutoclaving. Acta Agriculturae Scandinavica, 33, 171-175.MAKINO, H., TOGO, S., KUBOTA, T., MORIOKA, D., MORITA, T., KOBAYASHI, T., TANAKA, K., SHIMIZU,T., MATSUO, K., NAGASHIMA, Y. & SHIMADA, H. 2005. A good model of hepatic failure afterexcessive hepatectomy in mice. Journal of Surgical Research, 127, 171-176.MANNING, R. O., BROWN, T. P., WYATT, R. D. & FLETCHER, O. J. 1985. The Individual and CombinedEffects of Citrinin and Ochratoxin-a in Broi<strong>le</strong>r Chicks. Avian Diseases, 29, 986-997.MARASAS, W. F. O. 2001. Dis<strong>co</strong>very and occurr<strong>en</strong>ce of the fumonisins: A historical perspective.Environm<strong>en</strong>tal Health Perspectives, 109, 239-243.MARESCA, M. & FANTINI, J. 2010. Some food-associated my<strong>co</strong>toxins as pot<strong>en</strong>tial risk factors inhumans predisposed to chronic intestinal inflammatory diseases. Toxi<strong>co</strong>n, 56, 282-294.MARIN, D. E., GOUZE, M. E., TARANU, I. & OSWALD, I. P. 2007. Fumonisin B1 alters cell cyc<strong>le</strong>progression and inter<strong>le</strong>ukin-2 synthesis in swine peripheral blood mononuc<strong>le</strong>ar cells.Mo<strong>le</strong>cular Nutrition & Food Research, 51, 1406-1412.MARIN, D. E., TARANU, I., PASCALE, F., LIONIDE, A., BURLACU, R., BAILLY, J. D. & OSWALD, I. P. 2006.Sex-related differ<strong>en</strong>ces in the imm<strong>un</strong>e response of weanling pig<strong>le</strong>ts exposed to low doses offumonisin extract. British Journal of Nutrition, 95, 1185-1192.MARTINO, A., VOLPE, E., AURICCHIO, G., IZZI, V., POCCIA, F., MARIANI, F., COLIZZI, V. & BALDINI, P.M. 2007. Sphingosine 1-phosphate interferes on the differ<strong>en</strong>tiation of human monocytesinto <strong>co</strong>mpet<strong>en</strong>t d<strong>en</strong>dritic cells. Scandinavian Journal of Imm<strong>un</strong>ology, 65, 84-91.MARTINOVA, E. A. & MERRILL, A. H. 1995. Fumonisin B-1 Alters Sphingolipid Metabolism andImm<strong>un</strong>e F<strong>un</strong>ction in Balb/C Mice - Imm<strong>un</strong>ological Responses to Fumonisin B-1.My<strong>co</strong>pathologia, 130, 163-170.206
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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These are not the final page number
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These are not the final page number
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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