Effet chez le porcelet d'une exposition à un régime co-contaminé en ...
Effet chez le porcelet d'une exposition à un régime co-contaminé en ...
Effet chez le porcelet d'une exposition à un régime co-contaminé en ...
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INTRODUCTIONwhich slightly differs chemically from humic acids obtained from other sources. Effici<strong>en</strong>t results wereobtained in broi<strong>le</strong>r chick<strong>en</strong>s fed aflatoxin-<strong>co</strong>ntaminated diets and it was prov<strong>en</strong> that oxihumate ishighly effective in the amelioration of aflatoxi<strong>co</strong>sis in broi<strong>le</strong>rs. Furthermore, divinylb<strong>en</strong>z<strong>en</strong>e-styr<strong>en</strong>eshowed to reduce the absorption and the toxic effects of ZEA (Guerre, 2000) and T-2 toxin in rats(Carson and Smith, 1983) wh<strong>en</strong> using anion-exchange and not cation-exchange resins. This anionexchange resin has be<strong>en</strong> shown to prev<strong>en</strong>t zeara<strong>le</strong>none toxi<strong>co</strong>sis by binding the toxin in the digestivetract to prev<strong>en</strong>t absorption (Smith, 1980). Litt<strong>le</strong> information is availab<strong>le</strong> <strong>co</strong>ncerning chlorophyllin(CHL) binding capacity. Breinholt et al. (1995) supported that CHL is a pot<strong>en</strong>t dose-responsiveinhibitor of aflatoxin I, DNA adduction and hepatocarcinog<strong>en</strong>esis in the rainbow trout.Furthermore, Jouany (2007) indicated that alfalfa and oat fibers are capab<strong>le</strong> of reducing theestrog<strong>en</strong>ic effect of ZEA on rats and b<strong>le</strong>aching clays that had be<strong>en</strong> used to process canola oil werefo<strong>un</strong>d to <strong>le</strong>ss<strong>en</strong> the effects of T-2 (CAST, 2003).A trial <strong>co</strong>nducted with rats and swine to determine the pot<strong>en</strong>tial of dietary alfalfa as a treatm<strong>en</strong>tfor zeara<strong>le</strong>none toxi<strong>co</strong>sis showed that alfalfa inclusion in diet reduced the inhibitory effects of ZEA ongrowth and feed <strong>co</strong>nsumption, minimized ZEA-induced liver <strong>en</strong>largem<strong>en</strong>t, increased hepatic 3 -HSDactivity, reduced <strong>co</strong>nc<strong>en</strong>trations of residual ZEA liver and decreased uterine <strong>en</strong>largem<strong>en</strong>t. Thesestudies proved that dietary alfalfa promotes ZEA metabolism in rats and that this feedstuff may alsobe useful for treating ZEA toxi<strong>co</strong>sis in livestock (James and Smith, 1982).Besides micronized wheat fibers (MWF) were evaluated to decrease the <strong>le</strong>vels of ochratoxin A inplasma, kidney and liver of pig<strong>le</strong>ts fed a naturally <strong>co</strong>ntaminated diet. Results demonstrated asignificantly protective effect against usual increased kidneys and liver weights caused by OTA<strong>co</strong>ntaminateddiets. MWF significantly protected against high OTA <strong>co</strong>nc<strong>en</strong>tration in plasma (45.6%decrease), kidney (40.8% decrease) and liver weights (26.5% decrease). Thus, these results suggestthat the addition of MWF is effective in decreasing the bioavailability of OTA from <strong>co</strong>ntaminateddiets in pig<strong>le</strong>ts (Aoudia et al., 2009).83
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