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REFERENCES BIBLIOGRAPHIQUESMIAZZO, R., PERALTA, M. F., MAGNOLI, C., SALVANO, M., FERRERO, S., CHIACCHIERA, S. M.,CARVALHO, E. C. Q., ROSA, C. A. R. & DALCERO, A. 2005. Efficacy of sodium b<strong>en</strong>tonite as adetoxifier of broi<strong>le</strong>r feed <strong>co</strong>ntaminated with aflatoxin and fumonisin. Poultry Sci<strong>en</strong>ce, 84, 1-8.MILLER, E. R. & ULLREY, D. E. 1987. The Pig as a Model for Human-Nutrition. Annual Review ofNutrition, 7, 361-382.MOLL, W. D., HEINL, S., HARTINGER, D., GRIESSLER, K., KLINGENBRUNNER, V., VEKIRU, E., SCHWARTZ,H., KRSKA, R., GRABHERR, R. & SCHATZMAYR, G. Biodegradation of fumonisins. Proceedingsof the International Society for My<strong>co</strong>toxi<strong>co</strong>logy, 2009 Austria.MOLNAR, O., SCHATZMAYR, G., FUCHS, E. & PRILLINGER, H. 2004. Trichosporon my<strong>co</strong>toxinivorans spnov., a new yeast species useful in biological detoxification of various my<strong>co</strong>toxins. Systematicand Applied Microbiology, 27, 661-671.MONBALIU, S., VAN POUCKE, C., DETAVERNIER, C., DUMOULIN, F., VAN DE VELDE, M., SCHOETERS,E., VAN DYCK, S., AVERKIEVA, O., VAN PETEGHEM, C. & DE SAEGER, S. 2010. Occurr<strong>en</strong>ce ofMy<strong>co</strong>toxins in Feed as Analyzed by a Multi-My<strong>co</strong>toxin LC-MS/MS Method. Journal ofAgricultural and Food Chemistry, 58, 66-71.MOON, Y. & PESTKA, J. J. 2002. Vomitoxin-induced cyclooxyg<strong>en</strong>ase-2 g<strong>en</strong>e expression inmacrophages mediated by activation of ERK and p38 but not JNK mitog<strong>en</strong>-activated proteinkinases. Toxi<strong>co</strong>logical Sci<strong>en</strong>ces, 69, 373-382.MOON, Y. & PESTKA, J. J. 2003. Cyclooxyg<strong>en</strong>ase-2 mediates inter<strong>le</strong>ukin-6 upregulation by vomitoxin(deoxyniva<strong>le</strong>nol) in vitro and in vivo. Toxi<strong>co</strong>logy and Applied Pharma<strong>co</strong>logy, 187, 80-88.MORRIS, C. M., LI, Y. C., LEDOUX, D. R., BERMUDEZ, A. J. & ROTTINGHAUS, G. E. 1999. The individualand <strong>co</strong>mbined effects of feeding moniliformin, supplied by Fusarium fujikuroi culturematerial, and deoxyniva<strong>le</strong>nol in yo<strong>un</strong>g turkey poults. Poultry Sci<strong>en</strong>ce, 78, 1110-1115.MORRISSEY, R. E., NORRED, W. P., HINTON, D. M., COLE, R. J. & DORNER, J. W. 1987. CombinedEffects of the My<strong>co</strong>toxins Aflatoxin-B1 and Cyclopiazonic Acid on Sprague-Daw<strong>le</strong>y Rats. Foodand Chemical Toxi<strong>co</strong>logy, 25, 837-842.MURPHY, P. A., RICE, L. G. & ROSS, P. F. 1993. Fumonisin-B1, Fumonisin-B2, and Fumonisin-B3Cont<strong>en</strong>t of Iowa, Wis<strong>co</strong>nsin, and Illinois Corn and Corn Scre<strong>en</strong>ings. Journal of Agricultural andFood Chemistry, 41, 263-266.MUTUNGI, C., LAMUKA, P., ARIMI, S., GATHUMBI, J. & ONYANGO, C. 2008. The fate of aflatoxinsduring processing of maize into muthokoi - A traditional K<strong>en</strong>yan food. Food Control, 19, 714-721.NNORRED, W. P. & MORRISSEY, R. E. 1983. Effects of Long-Term Feeding of Ammoniated, Aflatoxin-Contaminated Corn to Fischer 344 Rats. Toxi<strong>co</strong>logy and Applied Pharma<strong>co</strong>logy, 70, 96-104.NORRED, W. P., VOSS, K. A., BACON, C. W. & RILEY, R. T. 1991. Effectiv<strong>en</strong>ess of Ammonia Treatm<strong>en</strong>tin Detoxification of Fumonisin Contaminated Corn. Food and Chemical Toxi<strong>co</strong>logy, 29, 815-819.NORRED, W. P., WANG, E., YOO, H., RILEY, R. T. & MERRILL, A. H. 1992. Invitro Toxi<strong>co</strong>logy ofFumonisins and the Mechanistic Implications. My<strong>co</strong>pathologia, 117, 73-78.OOBREMSKI, K., ZIELONKA, L., GAJECKA, M., JAKIMIUK, E., BAKULA, T., BARANOWSKI, M. & GAJECKI,M. 2008. Histological estimation of the small intestine wall after administration of feed<strong>co</strong>ntaining deoxyniva<strong>le</strong>nol, T-2 toxin and zeara<strong>le</strong>none in the pig. Polish Journal of VeterinarySci<strong>en</strong>ces, 11, 339-345.208
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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These are not the final page number
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These are not the final page number
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These are not the final page number
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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