REFERENCES BIBLIOGRAPHIQUESVEKIRU, E., FRUHAUF, S., SAHIN, M., OTTNER, F., SCHATZMAYR, G. & KRSKA, R. 2007. Investigation ofvarious adsorb<strong>en</strong>ts for their ability to bind aflatoxin B<sub>1</sub>. My<strong>co</strong>toxinResearch, 23, 27-33.VELDMAN, A. 1992. Effect of sorb<strong>en</strong>tia on carry-over of aflatoxin from <strong>co</strong>w feed to milk.Milchwiss<strong>en</strong>schaft, 47, 777-780.VENTURINI, M. C., QUIROGA, M. A., RISSO, M. A., DILORENZO, C., OMATA, Y., VENTURINI, L. &GODOY, H. 1996. My<strong>co</strong>toxin T-2 and aflatoxin B-1 as imm<strong>un</strong>osuppressors in mice chronicallyinfected with Toxoplasma gondii. Journal of Comparative Pathology, 115, 229-237.VERMA, J., JOHRI, T. S. & SWAIN, B. K. 2003. Effect of varying <strong>le</strong>vels of aflatoxin, ochratoxin and their<strong>co</strong>mbinations on the performance and egg quality characteristics in laying h<strong>en</strong>s. Asian-Australasian Journal of Animal Sci<strong>en</strong>ces, 16, 1015-1019.VERMA, J., JOHRI, T. S. & SWAIN, B. K. 2007. Effect of aflatoxin, ochratoxin and their <strong>co</strong>mbination onprotein and <strong>en</strong>ergy utilisation in white <strong>le</strong>ghorn laying h<strong>en</strong>s. Journal of the Sci<strong>en</strong>ce of Food andAgriculture, 87, 760-764.VERMA, J., JOHRI, T. S., SWAIN, B. K. & AMEENA, S. 2004. Effect of graded <strong>le</strong>vels of aflatoxin,ochratoxin and their <strong>co</strong>mbinations on the performance and imm<strong>un</strong>e response of broi<strong>le</strong>rs.British Poultry Sci<strong>en</strong>ce, 45, 512-518.VERMA, N., RETTENMEIER, A. W. & SCHMITZ-SPANKE, S. 2011. Rec<strong>en</strong>t advances in the use of Susscrofa (pig) as a model system for proteomic studies. Proteomics, 11, 1-18.VESELA, D., VESELY, D. & JELINEK, R. 1983. Toxic Effects of Ochratoxin-a and Citrinin, Alone and inCombination, on Chick<strong>en</strong> Embryos. Applied and Environm<strong>en</strong>tal Microbiology, 45, 91-93.VISCONTI, A., SOLFRIZZO, M., DOKO, M. B., BOENKE, A. & PASCALE, M. 1996. Stability of fumonisinsat differ<strong>en</strong>t storage periods and temperatures in gamma-irradiated maize. Food Additivesand Contaminants, 13, 929-938.VOSS, K. A., BACON, C. W., MEREDITH, F. I. & NORRED, W. P. 1996. Comparative subchronic toxicitystudies of nixtamalized and water-extracted Fusarium moniliforme culture material. Foodand Chemical Toxi<strong>co</strong>logy, 34, 623-&.VOSS, K. A., RILEY, R. T., BACON, C. W., MEREDITH, F. I. & NORRED, W. P. 1998. Toxicity andsphinganine <strong>le</strong>vels are <strong>co</strong>rrelated in rats fed fumonisin B-1 (FB1) or hydrolyzed FB1.Environm<strong>en</strong>tal Toxi<strong>co</strong>logy and Pharma<strong>co</strong>logy, 5, 101-104.VOSS, K. A., RILEY, R. T., NORRED, W. P., BACON, C. W., MEREDITH, F. I., HOWARD, P. C., PLATTNER,R. D., COLLINS, T. F. X., HANSEN, D. K. & PORTER, J. K. 2001. An overview of rod<strong>en</strong>t toxicities:Liver and kidney effects of fumonisins and Fusarium moniliforme. Environm<strong>en</strong>tal HealthPerspectives, 109, 259-266.VOSS, K. A., RILEY, R. T., SNOOK, M. E. & GELINEAU-VAN WAES, J. 2009. Reproductive andSphingolipid Metabolic Effects of Fumonisin B-1 and its Alkaline Hydrolysis Product in LM/BcMice: Hydrolyzed Fumonisin B-1 Did Not Cause Neural Tube Defects. Toxi<strong>co</strong>logical Sci<strong>en</strong>ces,112, 459-467.VOSS, K. A., SMITH, G. W. & HASCHEK, W. M. 2007. Fumonisins: Toxi<strong>co</strong>kinetics, mechanism of actionand toxicity. Animal Feed Sci<strong>en</strong>ce and Technology, 137, 299-325.WWACHE, Y. J., HBABI-HADDIOUI, L., GUZYLACK-PIRIOU, L., BELKHELFA, H., ROQUES, C. & OSWALD, I. P.2009. The my<strong>co</strong>toxin Deoxyniva<strong>le</strong>nol inhibits the cell surface expression of activationmarkers in human macrophages. Toxi<strong>co</strong>logy, 262, 239-244.WAES, J. G., STARR, L., MADDOX, J., ALEMAN, F., VOSS, K. A., WILBERDING, J. & RILEY, R. T. 2005.Maternal fumonisin exposure and risk for neural tube defects: Mechanisms in an in vivomouse model. Birth Defects Research Part a-Clinical and Mo<strong>le</strong>cular Teratology, 73, 487-497.219
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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Tableau 24 : Analyse de denrées ag
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DISCUSSION GENERALEet al., 2008b).
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DISCUSSION GENERALE• une réactio
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DISCUSSION GENERALE2. Les systèmes
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DISCUSSION GENERALEMycoplasma agala
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DISCUSSION GENERALEoptimale. Les au
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