REFERENCES BIBLIOGRAPHIQUESSCHWARTZ, H. E., MOLL, W. D., SCHATZMAYR, G. & KRSKA, R. An acce<strong>le</strong>rated method fordetermining sphingoid bases in serum of pigs. 31st My<strong>co</strong>toxin Workshop, 2009 Münster(Germany). 49.SCOTT, P. M. 1993. Fumonisins. International Journal of Food Microbiology, 18, 257-270.SCOTT, P. M. 1998. Industrial and farm detoxification processes for my<strong>co</strong>toxins. Revue De MedecineVeterinaire, 149, 543-548.SCOTT, P. M. & LAWRENCE, G. A. 1994. Stability and Prob<strong>le</strong>ms in Re<strong>co</strong>very of Fumonisins Added toCorn-Based Foods. Journal of Aoac International, 77, 541-545.SCUDAMORE, K. A. 2005. Prev<strong>en</strong>tion of ochratoxin A in <strong>co</strong>mmodities and likely effects of processingfractionation and animal feeds. Food Additives and Contaminants, 22, 17-25.SCUDAMORE, K. A. & PATEL, S. 2009. Occurr<strong>en</strong>ce of Fusarium my<strong>co</strong>toxins in maize imported into theUK, 2004-2007. Food Additives and Contaminants Part a-Chemistry Analysis Control Exposure& Risk Assessm<strong>en</strong>t, 26, 363-371.SEIFERLEIN, M., HUMPF, H. U., VOSS, K. A., SULLARDS, M. C., ALLEGOOD, J. C., WANG, E. & MERRILL,A. H. 2007. Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo byceramide synthase to form cytotoxic N-acyl-metabolites. Mo<strong>le</strong>cular Nutrition & FoodResearch, 51, 1120-1130.SHARMA, D., ASRANI, R. K., LEDOUX, D. R., JINDAL, N., ROTTINGHAUS, G. E. & GUPTA, V. K. 2008.Individual and <strong>co</strong>mbined effects of fumonisin B-1 and moniliformin on clini<strong>co</strong>pathologicaland cell-mediated imm<strong>un</strong>e response in Japanese quail. Poultry Sci<strong>en</strong>ce, 87, 1039-1051.SHEPHARD, G. S. 2008. Determination of my<strong>co</strong>toxins in human foods. Chemical Society Reviews, 37,2468-2477.SHEPHARD, G. S., THIEL, P. G., SYDENHAM, E. W., VLEGGAAR, R. & ALBERTS, J. F. 1994. Determinationof the My<strong>co</strong>toxin Fumonisin B-1 and Id<strong>en</strong>tification of Its Partially Hydrolyzed Metabolites inthe Feces of Nonhuman-Primates. Food and Chemical Toxi<strong>co</strong>logy, 32, 23-29.SHEPHERD, E. C., PHILLIPS, T. D., JOINER, G. N., KUBENA, L. F. & HEIDELBAUGH, N. D. 1981.Ochratoxin-a and P<strong>en</strong>icillic Acid Interaction in Mice. Journal of Environm<strong>en</strong>tal Sci<strong>en</strong>ce andHealth Part B-Pesticides Food Contaminants and Agricultural Wastes, 16, 557-573.SHETTY, P. H. & BHAT, R. V. 1999. A physical method for segregation of fumonisin-<strong>co</strong>ntaminatedmaize. Food Chemistry, 66, 371-374.SHI, Y. H., XU, Z. R., FENG, J. L. & WANG, C. Z. 2006. Efficacy of modified montmorillonit<strong>en</strong>ano<strong>co</strong>mposite to reduce the toxicity of aflatoxin in broi<strong>le</strong>r chicks. Animal Feed Sci<strong>en</strong>ce andTechnology, 129, 138-148.SHIFRIN, V. I. & ANDERSON, P. 1999. Trichothec<strong>en</strong>e my<strong>co</strong>toxins trigger a ribotoxic stress responsethat activates c-J<strong>un</strong> N-terminal kinase and p38 mitog<strong>en</strong>-activated protein kinase and inducesapoptosis. Journal of Biological Chemistry, 274, 13985-13992.SHIMA, J., TAKASE, S., TAKAHASHI, Y., IWAI, Y., FUJIMOTO, H., YAMAZAKI, M. & OCHI, K. 1997. Noveldetoxification of the trichothec<strong>en</strong>e my<strong>co</strong>toxin deoxyniva<strong>le</strong>nol by a soil bacterium isolated by<strong>en</strong>richm<strong>en</strong>t culture. Applied and Environm<strong>en</strong>tal Microbiology, 63, 3825-3830.SIRAJ, M. Y., PHILLIPS, T. D. & HAYES, A. W. 1981. Effects of the My<strong>co</strong>-Toxins Citrinin and Ochratoxinaon Hepatic Mixed-F<strong>un</strong>ction Oxidase and Ad<strong>en</strong>osine-Triphosphatase in Neonatal Rats.Journal of Toxi<strong>co</strong>logy and Environm<strong>en</strong>tal Health, 8, 131-140.SIVAKUMAR, G., DWIVEDI, P., SHARMA, A. K., KUMAR, M. & NIMALESAN, S. 2009. Fumonisin B1 andochratoxin A induced biochemical changes in yo<strong>un</strong>g ma<strong>le</strong> New Zealand White rabbits. IndianJournal of Veterinary Pathology, 33.SIWELA, A. H., SIWELA, M., MATINDI, G., DUBE, S. & NZIRAMASANGA, N. 2005. De<strong>co</strong>ntamination ofaflatoxin-<strong>co</strong>ntaminated maize by dehulling. Journal of the Sci<strong>en</strong>ce of Food and Agriculture,85, 2535-2538.215
REFERENCES BIBLIOGRAPHIQUESSMITH, E. E., KUBENA, L. F., BRAITHWAITE, C. E., HARVEY, R. B., PHILLIPS, T. D. & REINE, A. H. 1992.Toxi<strong>co</strong>logical Evaluation of Aflatoxin and Cyclopiazonic Acid in Broi<strong>le</strong>r-Chick<strong>en</strong>s. PoultrySci<strong>en</strong>ce, 71, 1136-1144.SMITH, T. K. 1980. Influ<strong>en</strong>ce of Dietary Fiber, Protein and Zeolite on Zeara<strong>le</strong>none Toxi<strong>co</strong>sis in Ratsand Swine. Journal of Animal Sci<strong>en</strong>ce, 50, 278-285.SMITH, T. K., MCMILLAN, E. G. & CASTILLO, J. B. 1997. Effect of feeding b<strong>le</strong>nds of Fusariummy<strong>co</strong>toxin-<strong>co</strong>ntaminated grains <strong>co</strong>ntaining deoxyniva<strong>le</strong>nol and fusaric acid on growth andfeed <strong>co</strong>nsumption of immature swine. Journal of Animal Sci<strong>en</strong>ce, 75, 2184-2191.SMITH, W. L., FITZPATRICK, F. A. & DENNIS, E. V. A. J. E. V. 1996. Chapter 11 The ei<strong>co</strong>sanoids:cyclooxyg<strong>en</strong>ase, lipoxyg<strong>en</strong>ase, and epoxyg<strong>en</strong>ase pathways. New Compreh<strong>en</strong>siveBiochemistry. Elsevier.SODERHOLM, J. D., OLAISON, G., PETERSON, K. H., FRANZEN, L. E., LINDMARK, T., WIREN, M.,TAGESSON, C. & SJODAHL, R. 2002. Augm<strong>en</strong>ted increase in tight j<strong>un</strong>ction permeability byluminal stimuli in the non-inflamed i<strong>le</strong>um of Crohn's disease. Gut, 50, 307-313.SOLFRIZZO, M., VISCONTI, A., AVANTAGGIATO, G., TORRES, A. & CHULZE, S. 2001. In vitro and in vivostudies to assess the effectiv<strong>en</strong>ess of cho<strong>le</strong>styramine as a binding ag<strong>en</strong>t for fumonisins.My<strong>co</strong>pathologia, 151, 147-153.SORIANO, J. M., GONZALEZ, L. & CATALA, A. I. 2005. Mechanism of action of sphingolipids and theirmetabolites in the toxicity of fumonisin B1. Progress in Lipid Research, 44, 345-356.SOVA, Z., POHUNKOVA, H., REISNEROVA, H., SLAMOVA, A. & HAISL, K. 1991. Hematological andHistological Response to the Diet Containing Aflatoxin B-1 and Zeolite in Broi<strong>le</strong>rs of Domestic-Fowl. Acta Veterinaria Brno, 60, 31-40.SPEIJERS, G. J. A. & SPEIJERS, M. H. M. 2004. Combined toxic effects of my<strong>co</strong>toxins. Toxi<strong>co</strong>logyLetters, 153, 91-98.STADNYK, A. W. 2002. Intestinal epithelial cells as a source of inflammatory cytokines andchemokines. Canadian Journal of Gastro<strong>en</strong>terology, 16, 241-246.STANLEY, V. G., OJO, R., WOLDESENBET, S., HUTCHINSON, D. H. & KUBENA, L. F. 1993. The Use ofSaccharomyces-Cerevisiae to Suppress the Effects of Aflatoxi<strong>co</strong>sis in Broi<strong>le</strong>r Chicks. PoultrySci<strong>en</strong>ce, 72, 1867-1872.STANLEY, V. G., WINSMAN, M., DUNKLEY, C., OGUNLEYE, T., DALEY, M., KRUEGER, W. F., SEFTON, A.E. & HINTON, A. 2004. The impact of yeast culture residue on the suppression of dietaryaflatoxin on the performance of broi<strong>le</strong>r breeder h<strong>en</strong>s. Journal of Applied Poultry Research,13, 533-539.STOEV, S. D., GOUNDASHEVA, D., MIRTCHEVA, T. & MANTLE, P. G. 2000. Susceptibility to se<strong>co</strong>ndarybacterial infections in growing pigs as an early response in ochratoxi<strong>co</strong>sis. Experim<strong>en</strong>tal andToxi<strong>co</strong>logic Pathology, 52, 287-296.STROUD, J. S., ENGLISH, E., DAVIDSON, S., HOPKINS, B. A., LATIMER, G., HAGLER, W. M., BROWNIE, C.& WHITLOW, L. W. 2006. Dietary additives to reduce aflatoxin transmission to milk of dairy<strong>co</strong>ws. Journal of Dairy Sci<strong>en</strong>ce, 89, 129.ŠTYRIAK, I., CONKOVÁ, E., KMEC, V., BÖHM, J. & RAZZAZI, E. 2001. The use of yeast for microbialdegradation of some se<strong>le</strong>cted my<strong>co</strong>toxins. My<strong>co</strong>toxin Research, 17, 24-27.SULYOK, M., KRSKA, R. & SCHUHMACHER, R. 2007. A liquid chromatography/tandem massspectrometric multi-my<strong>co</strong>toxin method for the quantification of 87 analytes and itsapplication to semi-quantitative scre<strong>en</strong>ing of moldy food samp<strong>le</strong>s. Analytical andBioanalytical Chemistry, 389, 1505-1523.SUNDSTØL ERIKSEN, G., PETTERSSON, H. & LUNDH, T. 2004. Comparative cytotoxicity ofdeoxyniva<strong>le</strong>nol, niva<strong>le</strong>nol, their acetylated derivatives and de-epoxy metabolites. Food andChemical Toxi<strong>co</strong>logy, 42, 619-624.216
- Page 2 and 3:
AUTEUR : Bertrand GRENIERTITRE : Ef
- Page 4 and 5:
REMERCIEMENTSLe travail ici présen
- Page 6 and 7:
J’ai une pensée particulière po
- Page 8 and 9:
Grenier, B., Loureiro-Bracarense, A
- Page 10 and 11:
TABLE DES MATIERES ................
- Page 12 and 13:
LISTE DES ABREVIATIONSAFAflatoxineD
- Page 14 and 15:
FIGURES ET TABLEAUXFigure 1 : Mycot
- Page 16 and 17:
INTRODUCTION8
- Page 18 and 19:
INTRODUCTIONCONTEXTE DE L’ETUDELe
- Page 20 and 21:
INTRODUCTIONElle se présentait sou
- Page 22 and 23:
INTRODUCTIONl’utilisation de ce m
- Page 24 and 25:
INTRODUCTION1. Les mycotoxines : g
- Page 26 and 27:
INTRODUCTIONc) La zéaralénone (vo
- Page 28 and 29:
INTRODUCTIONleucoencéphalomalacies
- Page 30 and 31:
INTRODUCTIONMycotoxins co-contamina
- Page 32 and 33:
INTRODUCTIONINTRODUCTIONFood safety
- Page 34 and 35:
INTRODUCTIONCHARACTERIZATION OF THE
- Page 36 and 37:
Quail(140 d)AF-FBRabbit(21 d)AF-FBR
- Page 38 and 39:
INTRODUCTIONdue to the ingestion of
- Page 40 and 41:
Table 2 : Interaction between Aflat
- Page 42 and 43:
(49 d) - RW-L ↗- Ab SRBC ↘- RW-
- Page 44 and 45:
INTRODUCTIONb) effects AF and OTA o
- Page 46 and 47:
INTRODUCTIONThe depletion of lympho
- Page 48 and 49:
AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
- Page 50 and 51:
INTRODUCTIONonly seen in birds give
- Page 52 and 53:
(30 d) 2AF-RUBGuinea pig 0.02 bw -(
- Page 54 and 55:
INTRODUCTIONbetween AF and CPA on t
- Page 56 and 57:
(21 day) - RBC, hemoglobin ↗- AST
- Page 58 and 59:
INTRODUCTIONII. INTERACTIONS BETWEE
- Page 60 and 61:
INTRODUCTIONwhereas in the experime
- Page 62 and 63:
INTRODUCTION2.2) TCT type A and BTw
- Page 64 and 65:
Table 6 : Interaction between Ochra
- Page 66 and 67:
T2-CPAChicken(28 d)T2-CPAChicken(21
- Page 68 and 69:
INTRODUCTIONexposed group (Brown et
- Page 70 and 71:
INTRODUCTION2.3) Interaction betwee
- Page 72 and 73:
INTRODUCTIONeffects in comparison t
- Page 74 and 75:
INTRODUCTION3. Procédés de décon
- Page 76 and 77:
INTRODUCTIONPhysical and chemical m
- Page 78 and 79:
INTRODUCTIONINTRODUCTIONConsumption
- Page 80 and 81:
INTRODUCTIONmm screen shows that fr
- Page 82 and 83:
INTRODUCTIONseparate the grain into
- Page 84 and 85:
Table 7 : toxicological evaluation
- Page 86 and 87:
INTRODUCTIONextrusion parameters ra
- Page 88 and 89:
INTRODUCTION- an important loss of
- Page 90 and 91:
INTRODUCTIONal., 2005). The fate of
- Page 92 and 93:
INTRODUCTIONby a steeping period. S
- Page 94 and 95:
INTRODUCTIONon cell tissue cultures
- Page 96 and 97:
INTRODUCTIONCONCLUSIONDetoxificatio
- Page 98 and 99:
INTRODUCTIONMycotoxin Reduction in
- Page 100 and 101:
INTRODUCTIONINTRODUCTIONMycotoxin-p
- Page 102 and 103:
INTRODUCTIONI. ADSORPTION OF MYCOTO
- Page 104 and 105:
Rats3000 ppb 0.5 %2500 ppb 0.5 %250
- Page 106 and 107:
INTRODUCTIONIn studies of the poten
- Page 108 and 109:
INTRODUCTIONSubstances investigated
- Page 110 and 111:
Table 9 : Outcome of yeast cell wal
- Page 112 and 113:
INTRODUCTIONFurthermore, cholestyra
- Page 114 and 115:
INTRODUCTIONwall peptidoglycans and
- Page 116 and 117:
INTRODUCTIONII. BIOLOGICAL DETOXIFI
- Page 118 and 119:
INTRODUCTIONdecrease in toxin-conce
- Page 120 and 121:
INTRODUCTIONCONCLUSIONPrevention an
- Page 122 and 123:
TRAVAILEXPERIMENTAL90
- Page 124 and 125:
TRAVAIL EXPERIMENTALtoxicité gén
- Page 126 and 127:
TRAVAIL EXPERIMENTALRESUME DES ETUD
- Page 128 and 129:
These are not the final page number
- Page 130 and 131:
These are not the final page number
- Page 132 and 133:
These are not the final page number
- Page 134 and 135:
These are not the final page number
- Page 136 and 137:
These are not the final page number
- Page 138 and 139:
These are not the final page number
- Page 140 and 141:
TRAVAIL EXPERIMENTALChronic ingesti
- Page 142 and 143:
TRAVAIL EXPERIMENTALINTRODUCTIONMyc
- Page 144 and 145:
TRAVAIL EXPERIMENTALMATERIAL & METH
- Page 146 and 147:
TRAVAIL EXPERIMENTALthrough a grade
- Page 148 and 149:
Figure 5ABCDVilli height (µm)5432a
- Page 150 and 151:
TRAVAIL EXPERIMENTALRESULTS1) Histo
- Page 152 and 153:
Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
- Page 154 and 155:
TRAVAIL EXPERIMENTAL3) Intestinal i
- Page 156 and 157:
TRAVAIL EXPERIMENTALtreated group t
- Page 158 and 159:
TRAVAIL EXPERIMENTALThe potencial e
- Page 160 and 161:
TRAVAIL EXPERIMENTALQuantification
- Page 162 and 163:
Figure 10 :(a) Réaction de deesté
- Page 164 and 165:
TRAVAIL EXPERIMENTALrévélé de l
- Page 166 and 167:
TRAVAIL EXPERIMENTALABSTRACTFumonis
- Page 168 and 169:
TRAVAIL EXPERIMENTALintestinal leve
- Page 170 and 171:
TRAVAIL EXPERIMENTAL3) Experimental
- Page 172 and 173:
TRAVAIL EXPERIMENTALthe importance
- Page 174 and 175:
Figure 11 : Effects of FB1 and HFB1
- Page 176 and 177:
Table 15 : Effects of FB1 and HFB1
- Page 178 and 179:
Table 17 : Effects of FB1 and HFB1
- Page 180 and 181:
TRAVAIL EXPERIMENTALDISCUSSIONThe a
- Page 182 and 183:
TRAVAIL EXPERIMENTALassociated lymp
- Page 184 and 185:
TRAVAIL EXPERIMENTALHartinger et al
- Page 186 and 187:
Figure 13 :(a) Transformation par v
- Page 188 and 189:
Figure 14 :Illustrations de la proc
- Page 190 and 191:
Figure 15 :Plan expérimental de la
- Page 192 and 193:
TRAVAIL EXPERIMENTAL4) Analyses du
- Page 194 and 195:
TRAVAIL EXPERIMENTAL9) Analyses sta
- Page 196 and 197:
TRAVAIL EXPERIMENTALRESULTATS1) Eff
- Page 198 and 199:
TRAVAIL EXPERIMENTAL2) Effet des ag
- Page 200 and 201:
TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
- Page 202 and 203:
TRAVAIL EXPERIMENTALL’exposition
- Page 204 and 205:
Figure 21 : Effet de l’exposition
- Page 206 and 207:
1,41,21,00,80,60,40,20,0IL‐8a,cc
- Page 208 and 209:
TRAVAIL EXPERIMENTALDISCUSSIONLes o
- Page 210 and 211:
TRAVAIL EXPERIMENTALœdèmes pulmon
- Page 212 and 213:
DISCUSSIONGENERALE160
- Page 214 and 215:
DISCUSSION GENERALEDans ce travail
- Page 216 and 217:
DISCUSSION GENERALEdes vaches laiti
- Page 218 and 219:
Tableau 24 : Analyse de denrées ag
- Page 220 and 221:
DISCUSSION GENERALEet al., 2008b).
- Page 222 and 223:
DISCUSSION GENERALE• une réactio
- Page 224 and 225:
DISCUSSION GENERALE2. Les systèmes
- Page 226 and 227: DISCUSSION GENERALEMycoplasma agala
- Page 228 and 229: DISCUSSION GENERALEoptimale. Les au
- Page 230 and 231: DISCUSSION GENERALEsphingomyéline
- Page 232 and 233: DISCUSSION GENERALEsignalisation ce
- Page 234 and 235: DISCUSSION GENERALEL’IMMUNITÉ IN
- Page 236 and 237: DISCUSSION GENERALEplus spécifique
- Page 238 and 239: DISCUSSION GENERALEsouligner que le
- Page 240 and 241: DISCUSSION GENERALELA CARBOXYLESTER
- Page 242 and 243: DISCUSSION GENERALEde HFB1. Toutefo
- Page 244 and 245: CONCLUSIONS184
- Page 246 and 247: CONCLUSIONSLes effets d’expositio
- Page 248 and 249: CONCLUSIONSest utilisée lorsque la
- Page 250 and 251: REFERENCES BIBLIOGRAPHIQUESAABDEL-W
- Page 252 and 253: REFERENCES BIBLIOGRAPHIQUESBHANDARI
- Page 254 and 255: REFERENCES BIBLIOGRAPHIQUESCASADO,
- Page 256 and 257: REFERENCES BIBLIOGRAPHIQUESDEGIRMEN
- Page 258 and 259: REFERENCES BIBLIOGRAPHIQUESETIENNE,
- Page 260 and 261: REFERENCES BIBLIOGRAPHIQUESGRENIER,
- Page 262 and 263: REFERENCES BIBLIOGRAPHIQUESHERZALLA
- Page 264 and 265: REFERENCES BIBLIOGRAPHIQUESKERKADI,
- Page 266 and 267: REFERENCES BIBLIOGRAPHIQUESKUMAR, M
- Page 268 and 269: REFERENCES BIBLIOGRAPHIQUESMARZOCCO
- Page 270 and 271: REFERENCES BIBLIOGRAPHIQUESODHAV, B
- Page 272 and 273: REFERENCES BIBLIOGRAPHIQUESPFOHL-LE
- Page 274 and 275: REFERENCES BIBLIOGRAPHIQUESREFAI, M
- Page 278 and 279: REFERENCES BIBLIOGRAPHIQUESSWANSON,
- Page 280 and 281: REFERENCES BIBLIOGRAPHIQUESVEKIRU,
- Page 282 and 283: REFERENCES BIBLIOGRAPHIQUESYAN, D.,
Change language