REFERENCES BIBLIOGRAPHIQUESHERZALLAH, S., ALSHAWABKEH, K. & AL FATAFTAH, A. 2008. Aflatoxin De<strong>co</strong>ntamination of ArtificiallyContaminated Feeds by S<strong>un</strong>light, gamma-Radiation, and Microwave Heating. Journal ofApplied Poultry Research, 17, 515-521.HOOGENBOOM, L. A. P., TULLIEZ, J., GAUTIER, J. P., COKER, R. D., MELCION, J. P., NAGLER, M. J.,POLMAN, T. H. G. & DELORT-LAVAL, J. 2001. Absorption, distribution and excretion ofaflatoxin-derived ammoniation products in lactating <strong>co</strong>ws. Food Additives and Contaminants,18, 47-58.HOPKINS, A., SMITH, G. W. & WHITLOW, L. W. 2008. Changes in milk aflatoxin <strong>co</strong>nc<strong>en</strong>trations inresponse to investigational sequestering ag<strong>en</strong>ts added to aflatoxin-<strong>co</strong>ntaminated diets fed tolactating Holstein <strong>co</strong>ws. Journal of Animal Sci<strong>en</strong>ce, 86, 268.HOWARD, P. C., COUCH, L. H., PATTON, R. E., EPPLEY, R. M., DOERGE, D. R., CHURCHWELL, M. I.,MARQUES, M. M. & OKERBERG, C. V. 2002. Comparison of the toxicity of several fumonisinderivatives in a 28-day feeding study with fema<strong>le</strong> B6C3F(1) mice. Toxi<strong>co</strong>logy and AppliedPharma<strong>co</strong>logy, 185, 153-165.HUFF, W. E. 1980. A Physical Method for the Segregation of Aflatoxin-Contaminated Corn. CerealChemistry, 57, 236-238.HUFF, W. E. & DOERR, J. A. 1981. Synergism betwe<strong>en</strong> Aflatoxin and Ochratoxin-a in Broi<strong>le</strong>r-Chick<strong>en</strong>s.Poultry Sci<strong>en</strong>ce, 60, 550-555.HUFF, W. E., DOERR, J. A., WABECK, C. J., CHALOUPKA, G. W., MAY, J. D. & MERKLEY, J. W. 1983.Individual and Combined Effects of Aflatoxin and Ochratoxin-a on Bruising in Broi<strong>le</strong>r-Chick<strong>en</strong>s. Poultry Sci<strong>en</strong>ce, 62, 1764-1771.HUFF, W. E., DOERR, J. A., WABECK, C. J., CHALOUPKA, G. W., MAY, J. D. & MERKLEY, J. W. 1984. TheIndividual and Combined Effects of Aflatoxin and Ochratoxin a on Various ProcessingParameters of Broi<strong>le</strong>r-Chick<strong>en</strong>s. Poultry Sci<strong>en</strong>ce, 63, 2153-2161.HUFF, W. E. & HAGLER, W. M. 1982. Evaluation of D<strong>en</strong>sity Segregation as a Means to Estimate theDegree of Aflatoxin Contamination of Corn. Cereal Chemistry, 59, 152-153.HUFF, W. E. & HAGLER, W. M. 1985. D<strong>en</strong>sity Segregation of Corn and Wheat Naturally Contaminatedwith Aflatoxin, Deoxyniva<strong>le</strong>nol and Zeara<strong>le</strong>none. Journal of Food Protection, 48, 416-420.HUFF, W. E., HARVEY, R. B., KUBENA, L. F. & ROTTINGHAUS, G. E. 1988. Toxic Synergism betwe<strong>en</strong>Aflatoxin and T-2 Toxin in Broi<strong>le</strong>r-Chick<strong>en</strong>s. Poultry Sci<strong>en</strong>ce, 67, 1418-1423.HUFF, W. E., KUBENA, L. F., HARVEY, R. B., HAGLER, W. M., SWANSON, S. P., PHILLIPS, T. D. &CREGER, C. R. 1986. Individual and Combined Effects of Aflatoxin and Deoxyniva<strong>le</strong>nol (Don,Vomitoxin) in Broi<strong>le</strong>r-Chick<strong>en</strong>s. Poultry Sci<strong>en</strong>ce, 65, 1291-1298.HUFF, W. E., KUBENA, L. F., HARVEY, R. B. & PHILLIPS, T. D. 1992. Efficacy of Hydrated SodiumCalcium Aluminosilicate to Reduce the Individual and Combined Toxicity of Aflatoxin andOchratoxin-A. Poultry Sci<strong>en</strong>ce, 71, 64-69.HULT, K., TEILING, A. & GATENBECK, S. 1976. Degradation of Ochratoxin-a by a Ruminant. Appliedand Environm<strong>en</strong>tal Microbiology, 32, 443-444.HUMPF, H. U., SCHMELZ, E. M., MEREDITH, F. I., VESPER, H., VALES, T. R., WANG, E., MENALDINO, D.S., LIOTTA, D. C. & MERRILL, A. H. 1998. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase - Formation of N-palmitoyl-aminop<strong>en</strong>tol producesa toxic metabolite of hydrolyzed fumonisin, AP(1), and a new category of ceramide synthaseinhibitor. Journal of Biological Chemistry, 273, 19060-19064.HUMPF, H. U. & VOSS, K. A. 2004. Effects of thermal food processing on the chemical structure andtoxicity of fumonisin my<strong>co</strong>toxins. Mo<strong>le</strong>cular Nutrition & Food Research, 48, 255-269.HUWIG, A., FREIMUND, S., KAPPELI, O. & DUTLER, H. 2001. My<strong>co</strong>toxin detoxication of animal feed bydiffer<strong>en</strong>t adsorb<strong>en</strong>ts. Toxi<strong>co</strong>logy Letters, 122, 179-188.HYMERY, N., SIBIRIL, Y. & PARENT-MASSIN, D. 2006. In vitro effects of trichothec<strong>en</strong>es on humand<strong>en</strong>dritic cells. Toxi<strong>co</strong>logy in Vitro, 20, 899-909.201
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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