REFERENCES BIBLIOGRAPHIQUESKERKADI, A., BARRIAULT, C., TUCHWEBER, B., FROHLICH, A. A., MARQUARDT, R. R., BOUCHARD, G. &YOUSEF, I. M. 1998. Dietary cho<strong>le</strong>styramine reduces ochratoxin A-induced nephrotoxicity inthe rat by decreasing plasma <strong>le</strong>vels and <strong>en</strong>hancing fecal excretion of the toxin. Journal ofToxi<strong>co</strong>logy and Environm<strong>en</strong>tal Health-Part a-Curr<strong>en</strong>t Issues, 53, 231-250.KIDD, M. T., HAGLER, W. M. & QURESHI, M. A. 1995. Trichothec<strong>en</strong>e My<strong>co</strong>toxins Depress theMononuc<strong>le</strong>ar-Phagocytic System of Yo<strong>un</strong>g Turkeys. Imm<strong>un</strong>opharma<strong>co</strong>logy andImm<strong>un</strong>otoxi<strong>co</strong>logy, 17, 385-398.KIESSLING, K. H., PETTERSSON, H., SANDHOLM, K. & OLSEN, M. 1984. Metabolism of Aflatoxin,Ochratoxin, Zeara<strong>le</strong>none, and 3 Trichothec<strong>en</strong>es by Intact Rum<strong>en</strong> Fluid, Rum<strong>en</strong> Protozoa, andRum<strong>en</strong> Bacteria. Applied and Environm<strong>en</strong>tal Microbiology, 47, 1070-1073.KIM, E. K., SCOTT, P. M. & LAU, B. P. Y. 2003. Hidd<strong>en</strong> fumonisin in <strong>co</strong>rn flakes. Food Additives andContaminants Part a-Chemistry Analysis Control Exposure & Risk Assessm<strong>en</strong>t, 20, 161-169.KING, R. R., MCQUEEN, R. E., LEVESQUE, D. & GREENHALGH, R. 1984. Transformation ofDeoxyniva<strong>le</strong>nol (Vomitoxin) by Rum<strong>en</strong> Microorganisms. Journal of Agricultural and FoodChemistry, 32, 1181-1183.KINSER, S., JIA, Q. S., LI, M. X., LAUGHTER, A., CORNWELL, P. D., CORTON, J. C. & PESTKA, J. J. 2004.G<strong>en</strong>e expression profiling in sp<strong>le</strong><strong>en</strong>s of deoxyniva<strong>le</strong>nol-exposed mice: Immediate early g<strong>en</strong>esas primary targets. Journal of Toxi<strong>co</strong>logy and Environm<strong>en</strong>tal Health-Part a-Curr<strong>en</strong>t Issues, 67,1423-1441.KIRAN, M. M., DEMET, O., ORTATATH, M. & OGUZ, H. 1998. The prev<strong>en</strong>tive effect ofpolyvinylpolypyrrolidone on aflatoxi<strong>co</strong>sis in broi<strong>le</strong>rs. Avian Pathology, 27, 250-255.KITCHEN, D. N., CARLTON, W. W. & TUITE, J. 1977a. Ochratoxin-a and Citrinin Induced Nephrosis inBeag<strong>le</strong> Dogs .1. Clinical and Clini<strong>co</strong>pathological Features. Veterinary Pathology, 14, 154-172.KITCHEN, D. N., CARLTON, W. W. & TUITE, J. 1977b. Ochratoxin-a and Citrinin Induced Nephrosis inBeag<strong>le</strong> Dogs .2. Pathology. Veterinary Pathology, 14, 261-272.KNOL, W., BOL, J. & HUIS IN'T VELD, J. H. J. 1990. Detoxification of aflatoxin B1 in feeds by Rhizopusoryzae in solid state. In: ZEUTHEN, P., CHEF TEL, J. C., ERIKSSON, C., GORMLEY, T. R., LINKO, P.& PAULUS, K. (eds.) Food Biotechnology. London: Elsevier Applied Sci<strong>en</strong>ce.KOLF-CLAUW, M., CASTELLOTE, J., JOLY, B., BOURGES-ABELLA, N., RAYMOND-LETRON, I., PINTON, P.& OSWALD, I. P. 2009. Developm<strong>en</strong>t of a pig jej<strong>un</strong>al explant culture for studying thegastrointestinal toxicity of the my<strong>co</strong>toxin deoxyniva<strong>le</strong>nol: Histopathological analysis.Toxi<strong>co</strong>logy in Vitro, 23, 1580-1584.KOLLARCZIK, B., GAREIS, M. & HANELT, M. 1994. In vitro transformation of the Fusarium my<strong>co</strong>toxinsdeoxyniva<strong>le</strong>nol and zeara<strong>le</strong>none by the normal gut microflora of pigs. Natural Toxins, 2, 105-110.KOLOSSOVA, A., STROKA, J., BREIDBACH, A., KROEGER, K., AMBROSIO, M., BOUTEN, K. & ULBERTH, F.2009. Evaluation of the effect of my<strong>co</strong>toxin binders in animal feed on the analyticalperformance of standardised methods for the determination of my<strong>co</strong>toxins in feed. JCRsci<strong>en</strong>tific and technical reports, 6-12.KOUADIO, J. H., DANO, S. D., MOUKHA, S., MOBIO, T. A. & CREPPY, E. E. 2007. Effects of<strong>co</strong>mbinations of Fusarium my<strong>co</strong>toxins on the inhibition of macromo<strong>le</strong>cular synthesis,malondialdehyde <strong>le</strong>vels, DNA methylation and fragm<strong>en</strong>tation, and viability in Ca<strong>co</strong>-2 cells.Toxi<strong>co</strong>n, 49, 306-317.KUBENA, L. F., EDRINGTON, T. S., HARVEY, R. B., BUCKLEY, S. A., PHILLIPS, T. D., ROTTINGHAUS, G. E.& CASPER, H. H. 1997a. Individual and <strong>co</strong>mbined effects of fumonisin B1 pres<strong>en</strong>t in Fusariummoniliforme culture material and T-2 toxin or deoxyniva<strong>le</strong>nol in broi<strong>le</strong>r chicks. Poult Sci, 76,1239-47.KUBENA, L. F., EDRINGTON, T. S., HARVEY, R. B., PHILLIPS, T. D., SARR, A. B. & ROTTINGHAUS, G. E.1997b. Individual and <strong>co</strong>mbined effects of fumonisin B-1 pres<strong>en</strong>t in Fusarium moniliforme203
REFERENCES BIBLIOGRAPHIQUESculture material and diacetoxyscirp<strong>en</strong>ol or ochratoxin A in turkey poults. Poultry Sci<strong>en</strong>ce, 76,256-264.KUBENA, L. F., EDRINGTON, T. S., KAMPS-HOLTZAPPLE, C., HARVEY, R. B., ELISSALDE, M. H. &ROTTINGHAUS, G. E. 1995a. Influ<strong>en</strong>ce of fumonisin B1, pres<strong>en</strong>t in Fusarium moniliformeculture material, and T-2 toxin on turkey poults. Poult Sci, 74, 306-13.KUBENA, L. F., EDRINGTON, T. S., KAMPSHOLTZAPPLE, C., HARVEY, R. B., ELISSALDE, M. H. &ROTTINGHAUS, G. E. 1995b. Effects of Feeding Fumonisin B-1 Pres<strong>en</strong>t in Fusarium-Moniliforme Culture Material and Aflatoxin Singly and in Combination to Turkey Poults.Poultry Sci<strong>en</strong>ce, 74, 1295-1303.KUBENA, L. F., HARVEY, R. B., BAILEY, R. H., BUCKLEY, S. A. & ROTTINGHAUS, G. E. 1998. Effects of ahydrated sodium calcium aluminosilicate (T-Bind (TM)) on my<strong>co</strong>toxi<strong>co</strong>sis in yo<strong>un</strong>g broi<strong>le</strong>rchick<strong>en</strong>s. Poultry Sci<strong>en</strong>ce, 77, 1502-1509.KUBENA, L. F., HARVEY, R. B., BUCKLEY, S. A., BAILEY, R. H. & ROTTINGHAUS, G. E. 1999. Effects oflong-term feeding of diets <strong>co</strong>ntaining moniliformin, supplied by Fusarium fujikuroi culturematerial, and fumonisin, supplied by Fusarium moniliforme culture material, to laying h<strong>en</strong>s.Poultry Sci<strong>en</strong>ce, 78, 1499-1505.KUBENA, L. F., HARVEY, R. B., BUCKLEY, S. A., EDRINGTON, T. S. & ROTTINGHAUS, G. E. 1997c.Individual and <strong>co</strong>mbined effects of moniliformin pres<strong>en</strong>t in Fusarium fujikuroi culturematerial and aflatoxin in broi<strong>le</strong>r chicks. Poultry Sci<strong>en</strong>ce, 76, 265-270.KUBENA, L. F., HARVEY, R. B., EDRINGTON, T. S. & ROTTINGHAUS, G. E. 1994a. Influ<strong>en</strong>ce ofOchratoxin-a and Diacetoxyscirp<strong>en</strong>ol Singly and in Combination on Broi<strong>le</strong>r-Chick<strong>en</strong>s. PoultrySci<strong>en</strong>ce, 73, 408-415.KUBENA, L. F., HARVEY, R. B., HUFF, W. E., CORRIER, D. E., PHILLIPS, T. D. & ROTTINGHAUS, G. E.1989a. Influ<strong>en</strong>ce of Ochratoxin-a and T-2 Toxin Singly and in Combination on Broi<strong>le</strong>r-Chick<strong>en</strong>s. Poultry Sci<strong>en</strong>ce, 68, 867-872.KUBENA, L. F., HARVEY, R. B., HUFF, W. E., CORRIER, D. E., PHILLIPS, T. D. & ROTTINGHAUS, G. E.1990. Efficacy of a Hydrated Sodium Calcium Aluminosilicate to Reduce the Toxicity ofAflatoxin and T-2 Toxin. Poultry Sci<strong>en</strong>ce, 69, 1078-1086.KUBENA, L. F., HARVEY, R. B., HUFF, W. E., ELISSALDE, M. H., YERSIN, A. G., PHILLIPS, T. D. &ROTTINGHAUS, G. E. 1993a. Efficacy of a Hydrated Sodium Calcium Aluminosilicate to Reducethe Toxicity of Aflatoxin and Diacetoxyscirp<strong>en</strong>ol. Poultry Sci<strong>en</strong>ce, 72, 51-59.KUBENA, L. F., HARVEY, R. B., PHILLIPS, T. D. & CLEMENT, B. A. 1993b. Effect of Hydrated SodiumCalcium Aluminosilicates on Aflatoxi<strong>co</strong>sis in Broi<strong>le</strong>r Chicks. Poultry Sci<strong>en</strong>ce, 72, 651-657.KUBENA, L. F., HUFF, W. E., HARVEY, R. B., CORRIER, D. E., PHILLIPS, T. D. & CREGER, C. R. 1988.Influ<strong>en</strong>ce of ochratoxin A and deoxyniva<strong>le</strong>nol on growing broi<strong>le</strong>r chicks. Poult Sci, 67, 253-60.KUBENA, L. F., HUFF, W. E., HARVEY, R. B., PHILLIPS, T. D. & ROTTINGHAUS, G. E. 1989b. Individualand <strong>co</strong>mbined toxicity of deoxyniva<strong>le</strong>nol and T-2 toxin in broi<strong>le</strong>r chicks. Poult Sci, 68, 622-6.KUBENA, L. F., HUFF, W. E., HARVEY, R. B., YERSIN, A. G., ELISSALDE, M. H., WITZEL, D. A., GIROIR, L.E., PHILLIPS, T. D. & PETERSEN, H. D. 1991. Effects of a Hydrated Sodium CalciumAluminosilicate on Growing Turkey Poults During Aflatoxi<strong>co</strong>sis. Poultry Sci<strong>en</strong>ce, 70, 1823-1830.KUBENA, L. F., PHILLIPS, T. D., WITZEL, D. A. & HEIDELBAUGH, N. D. 1984. Toxicity of Ochratoxin-aand P<strong>en</strong>icillic Acid to Chicks. Bul<strong>le</strong>tin of Environm<strong>en</strong>tal Contamination and Toxi<strong>co</strong>logy, 32,711-716.KUBENA, L. F., SMITH, E. E., GENTLES, A., HARVEY, R. B., EDRINGTON, T. S., PHILLIPS, T. D. &ROTTINGHAUS, G. E. 1994b. Individual and Combined Toxicity of T-2 Toxin and CyclopiazonicAcid in Broi<strong>le</strong>r Chicks. Poultry Sci<strong>en</strong>ce, 73, 1390-1397.KUMAR, M., DWIVEDI, P., SHARMA, A., SINGH, N. & PATIL, R. 2007. Ochratoxin A and citrininnephrotoxicity in New Zealand White rabbits: an ultrastructural assessm<strong>en</strong>t.My<strong>co</strong>pathologia, 163, 21-30.204
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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These are not the final page number
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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