REFERENCES BIBLIOGRAPHIQUESDEGIRMENCIOGLU, N., ESECALI, H., COKAL, Y. & BILGIC, M. 2005. From safety feed to safety food: theapplication of HACCP in my<strong>co</strong>toxin <strong>co</strong>ntrol. Archive Zootechnic, 8, 19-32.DEL BIANCHI, M., OLIVEIRA, C. A. F., ALBUQUERQUE, R., GUERRA, J. L. & CORREA, B. 2005. Effects ofprolonged oral administration of aflatoxin B-1 and fumonisin B-1 in broi<strong>le</strong>r chick<strong>en</strong>s. PoultrySci<strong>en</strong>ce, 84, 1835-1840.DENLI, M., BLANDON, J. C., GUYNOT, M. E., SALADO, S. & PEREZ, J. F. 2008. Efficacy of a NewOchratoxin-Binding Ag<strong>en</strong>t (OcraTox) to Co<strong>un</strong>teract the De<strong>le</strong>terious Effects of Ochratoxin A inLaying H<strong>en</strong>s. Poultry Sci<strong>en</strong>ce, 87, 2266-2272.DENLI, M., BLANDON, J. C., GUYNOT, M. E., SALADO, S. & PEREZ, J. F. 2009. Effects of dietaryAflaDetox on performance, serum biochemistry, histopathological changes, and aflatoxinresidues in broi<strong>le</strong>rs exposed to aflatoxin B-1. Poultry Sci<strong>en</strong>ce, 88, 1444-1451.DESAI, K., SULLARDS, M. C., ALLEGOOD, J., WANG, E., SCHMELZ, E. M., HARTL, M., HUMPF, H. U.,LIOTTA, D. C., PENG, Q. & MERRILL, A. H. 2002. Fumonisins and fumonisin analogs asinhibitors of ceramide synthase and inducers of apoptosis. Biochimica Et Biophysica Acta-Mo<strong>le</strong>cular and Cell Biology of Lipids, 1585, 188-192.DEVRIENDT, B., GALLOIS, M., VERDONCK, F., WACHE, Y., BIMCZOK, D., OSWALD, I. P., GODDEERIS, B.M. & COX, E. 2009. The food <strong>co</strong>ntaminant fumonisin B-1 reduces the maturation of porcineCD11R1(+) intestinal antig<strong>en</strong> pres<strong>en</strong>ting cells and antig<strong>en</strong>-specific imm<strong>un</strong>e responses, <strong>le</strong>adingto a prolonged intestinal ETEC infection. Veterinary Research, 40.DIAZ-LLANO, G. & SMITH, T. K. 2006. Effects of feeding grains naturally <strong>co</strong>ntaminated with Fusariummy<strong>co</strong>toxins with and without a polymeric glu<strong>co</strong>mannan my<strong>co</strong>toxin adsorb<strong>en</strong>t onreproductive performance and serum chemistry of pregnant gilts. Journal of Animal Sci<strong>en</strong>ce,84, 2361-2366.DIAZ, G. J. 2002. Evaluation of the efficacy of a feed additive to ameliorate the toxic effects of 4,15-diacetoxiscirp<strong>en</strong>ol in growing chicks. Poultry Sci<strong>en</strong>ce, 81, 1492-1495.DIAZ, G. J., CORTES, A. & ROLDAN, L. 2005. Evaluation of the efficacy of four feed additives againstthe adverse effects of T-2 toxin in growing broi<strong>le</strong>r chick<strong>en</strong>s. Journal of Applied PoultryResearch, 14, 226-231.DIAZ, G. J., SQUIRES, E. J., JULIAN, R. J. & BOERMANS, H. J. 1994. Individual and Combined Effects ofT-2 Toxin and Das in Laying H<strong>en</strong>s. British Poultry Sci<strong>en</strong>ce, 35, 393-405.DILKIN, P., HASSEGAWA, R., REIS, T. A., MALLMANN, C. A. & CORREA, B. 2004. Intoxicaçaoexperim<strong>en</strong>tal de suinos por fumonisinas. Ciência Rural, 34, 175-181.DILKIN, P., ZORZETE, P., MALLMANN, C. A., GOMES, J. D. F., UTIYAMA, C. E., OETTING, L. L. & CORREA,B. 2003. Toxi<strong>co</strong>logical effects of chronic low doses of aflatoxin B-1 and fumonisin B-1-<strong>co</strong>ntaining Fusarium mondiforme culture material in weaned pig<strong>le</strong>ts. Food and ChemicalToxi<strong>co</strong>logy, 41, 1345-1353.DIXON, J. B., KANNEWISCHER, I., ARVIDE, M. G. T. & VELAZQUEZ, A. L. B. 2008. Aflatoxinsequestration in animal feeds by quality-labe<strong>le</strong>d smectite clays: An introductory plan. AppliedClay Sci<strong>en</strong>ce, 40, 201-208.DOLLEAR, F. G. 1969. Detoxification of Aflatoxins in Foods and Feeds. Aflatoxin-Sci<strong>en</strong>tific Backgro<strong>un</strong>d,Control, and Implications, L.A. Goldblatt (Ed.), Academic Press, New York, NY, 359-391.DOMBRINK-KURTZMAN, M. A., DVORAK, T. J., BARRON, M. E. & ROONEY, L. W. 2000. Effect ofnixtamalization (alkaline <strong>co</strong>oking) on fumonisin-<strong>co</strong>ntaminated <strong>co</strong>rn for production of masaand tortillas. Journal of Agricultural and Food Chemistry, 48, 5781-5786.DOMIJAN, A. M., PERAICA, M., VRDOLJAK, A. L., RADIC, B., ZLENDER, V. & FUCHS, R. 2007. Theinvolvem<strong>en</strong>t of oxidative stress in ochratoxin A and fumonisin B-1 toxicity in rats. Mo<strong>le</strong>cularNutrition & Food Research, 51, 1147-1151.DONG, C., DAVIS, R. J. & FLAVELL, R. A. 2002. MAP kinases in the imm<strong>un</strong>e response. Annual Review ofImm<strong>un</strong>ology, 20, 55-72.195
REFERENCES BIBLIOGRAPHIQUESDOYLE, M. P., APPLEBAUM, R. S., BRACKETT, R. E. & MARTH, E. H. 1982. Physical, Chemical andBiological Degradation of My<strong>co</strong>-Toxins in Foods and Agricultural Commodities. Journal ofFood Protection, 45, 964-971.DRESDEN-OSBORNE, C. & NOBLET, G. P. 2002. Fumonisin B-1 affects viability and alters nitric oxideproduction of a murine macrophage cell line. International Imm<strong>un</strong>opharma<strong>co</strong>logy, 2, 1087-1093.DROCHNER, W., SCHOLLENBERGER, M., PIEPHO, H. P., GOTZ, S., LAUBER, U., TAFAJ, M., KLOBASA, F.,WEILER, U., CLAUS, R. & STEFFL, M. 2004. Serum IgA-promoting effects induced by feed loads<strong>co</strong>ntaining isolated deoxyniva<strong>le</strong>nol (DON) in growing pig<strong>le</strong>ts. Journal of Toxi<strong>co</strong>logy andEnvironm<strong>en</strong>tal Health-Part a-Curr<strong>en</strong>t Issues, 67, 1051-1067.DUGYALA, R. R., SHARMA, R. P., TSUNODA, M. & RILEY, R. T. 1998. Tumor necrosis factor-alpha as a<strong>co</strong>ntributor in fumonisin B-1 toxicity. Journal of Pharma<strong>co</strong>logy and Experim<strong>en</strong>talTherapeutics, 285, 317-324.DUTTON, M. F., WESTLAKE, K. & ANDERSON, M. S. 1984. The Interaction betwe<strong>en</strong> Additives, Yeastsand Patulin Production in Grass-Silage. My<strong>co</strong>pathologia, 87, 29-33.DUVICK, J. 2001. Prospects for reducing fumonisin <strong>co</strong>ntamination of maize through g<strong>en</strong>eticmodification. Environm<strong>en</strong>tal Health Perspectives, 109, 337-342.DVORSKA, J. E., PAPPAS, A. C., KARADAS, F., SPEAKE, B. K. & SURAI, P. F. 2007. Protective effect ofmodified glu<strong>co</strong>mannans and organic se<strong>le</strong>nium against antioxidant dep<strong>le</strong>tion in the chick<strong>en</strong>liver due to T-2 toxin-<strong>co</strong>ntaminated feed <strong>co</strong>nsumption. Comparative Biochemistry andPhysiology C-Toxi<strong>co</strong>logy & Pharma<strong>co</strong>logy, 145, 582-587.EEDRINGTON, T. S., HARVEY, R. B. & KUBENA, L. F. 1995. Toxic Effects of Aflatoxin-B-1 and Ochratoxina,Alone and in Combination, on Chick<strong>en</strong> Embryos. Bul<strong>le</strong>tin of Environm<strong>en</strong>tal Contaminationand Toxi<strong>co</strong>logy, 54, 331-336.EDRINGTON, T. S., KUBENA, L. F., HARVEY, R. B. & ROTTINGHAUS, G. E. 1997. Influ<strong>en</strong>ce of asuperactivated char<strong>co</strong>al on the toxic effects of aflatoxin or T-2 toxin in growing broi<strong>le</strong>rs.Poultry Sci<strong>en</strong>ce, 76, 1205-1211.EFSA, European Food Safety Authority, 2005. Opinion of the Sci<strong>en</strong>tific Panel on Contaminants in FoodChain on a request from the Commission related to fumonisins as <strong>un</strong>desirab<strong>le</strong> substances inanimal feed. The EFSA Journal, 235, 1-32.EL-NEZAMI, H., MYKKANEN, H., KANKAANPAA, P., SALMINEN, S. & AHOKAS, J. 2000. Ability ofLactobacillus and Propionibacterium strains to remove aflatoxin B-1 from the chick<strong>en</strong>duod<strong>en</strong>um. Journal of Food Protection, 63, 549-552.EL-NEZAMI, H., POLYCHRONAKI, N., SALMINEN, S. & MYKKANEN, H. 2002a. Binding rather thanmetabolism may explain the interaction of two food-grade Lactobacillus strains withzeara<strong>le</strong>none and its derivative alpha-zeara<strong>le</strong>nol. Applied and Environm<strong>en</strong>tal Microbiology, 68,3545-3549.EL-NEZAMI, H. S., CHREVATIDIS, A., AURIOLA, S., SALMINEN, S. & MYKKANEN, H. 2002b. Removal of<strong>co</strong>mmon Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium. FoodAdditives and Contaminants, 19, 680-686.ELSHARKAWY, S. & ABULHAJJ, Y. 1987. Microbial Transformation of Zeara<strong>le</strong>none .1. Formation ofZeara<strong>le</strong>none-4-O-Beta-Glu<strong>co</strong>side. Journal of Natural Products, 50, 520-521.ELSHARKAWY, S. & ABULHAJJ, Y. J. 1988. Microbial C<strong>le</strong>avage of Zeara<strong>le</strong>none. X<strong>en</strong>obiotica, 18, 365-371.ENONGENE, E. N., SHARMA, R. P., BHANDARI, N., VOSS, K. A. & RILEY, R. T. 2000. Disruption ofsphingolipid metabolism in small intestines, liver and kidney of mice dosed subcutaneouslywith fumonisin B-1. Food and Chemical Toxi<strong>co</strong>logy, 38, 793-799.196
- Page 2 and 3:
AUTEUR : Bertrand GRENIERTITRE : Ef
- Page 4 and 5:
REMERCIEMENTSLe travail ici présen
- Page 6 and 7:
J’ai une pensée particulière po
- Page 8 and 9:
Grenier, B., Loureiro-Bracarense, A
- Page 10 and 11:
TABLE DES MATIERES ................
- Page 12 and 13:
LISTE DES ABREVIATIONSAFAflatoxineD
- Page 14 and 15:
FIGURES ET TABLEAUXFigure 1 : Mycot
- Page 16 and 17:
INTRODUCTION8
- Page 18 and 19:
INTRODUCTIONCONTEXTE DE L’ETUDELe
- Page 20 and 21:
INTRODUCTIONElle se présentait sou
- Page 22 and 23:
INTRODUCTIONl’utilisation de ce m
- Page 24 and 25:
INTRODUCTION1. Les mycotoxines : g
- Page 26 and 27:
INTRODUCTIONc) La zéaralénone (vo
- Page 28 and 29:
INTRODUCTIONleucoencéphalomalacies
- Page 30 and 31:
INTRODUCTIONMycotoxins co-contamina
- Page 32 and 33:
INTRODUCTIONINTRODUCTIONFood safety
- Page 34 and 35:
INTRODUCTIONCHARACTERIZATION OF THE
- Page 36 and 37:
Quail(140 d)AF-FBRabbit(21 d)AF-FBR
- Page 38 and 39:
INTRODUCTIONdue to the ingestion of
- Page 40 and 41:
Table 2 : Interaction between Aflat
- Page 42 and 43:
(49 d) - RW-L ↗- Ab SRBC ↘- RW-
- Page 44 and 45:
INTRODUCTIONb) effects AF and OTA o
- Page 46 and 47:
INTRODUCTIONThe depletion of lympho
- Page 48 and 49:
AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
- Page 50 and 51:
INTRODUCTIONonly seen in birds give
- Page 52 and 53:
(30 d) 2AF-RUBGuinea pig 0.02 bw -(
- Page 54 and 55:
INTRODUCTIONbetween AF and CPA on t
- Page 56 and 57:
(21 day) - RBC, hemoglobin ↗- AST
- Page 58 and 59:
INTRODUCTIONII. INTERACTIONS BETWEE
- Page 60 and 61:
INTRODUCTIONwhereas in the experime
- Page 62 and 63:
INTRODUCTION2.2) TCT type A and BTw
- Page 64 and 65:
Table 6 : Interaction between Ochra
- Page 66 and 67:
T2-CPAChicken(28 d)T2-CPAChicken(21
- Page 68 and 69:
INTRODUCTIONexposed group (Brown et
- Page 70 and 71:
INTRODUCTION2.3) Interaction betwee
- Page 72 and 73:
INTRODUCTIONeffects in comparison t
- Page 74 and 75:
INTRODUCTION3. Procédés de décon
- Page 76 and 77:
INTRODUCTIONPhysical and chemical m
- Page 78 and 79:
INTRODUCTIONINTRODUCTIONConsumption
- Page 80 and 81:
INTRODUCTIONmm screen shows that fr
- Page 82 and 83:
INTRODUCTIONseparate the grain into
- Page 84 and 85:
Table 7 : toxicological evaluation
- Page 86 and 87:
INTRODUCTIONextrusion parameters ra
- Page 88 and 89:
INTRODUCTION- an important loss of
- Page 90 and 91:
INTRODUCTIONal., 2005). The fate of
- Page 92 and 93:
INTRODUCTIONby a steeping period. S
- Page 94 and 95:
INTRODUCTIONon cell tissue cultures
- Page 96 and 97:
INTRODUCTIONCONCLUSIONDetoxificatio
- Page 98 and 99:
INTRODUCTIONMycotoxin Reduction in
- Page 100 and 101:
INTRODUCTIONINTRODUCTIONMycotoxin-p
- Page 102 and 103:
INTRODUCTIONI. ADSORPTION OF MYCOTO
- Page 104 and 105:
Rats3000 ppb 0.5 %2500 ppb 0.5 %250
- Page 106 and 107:
INTRODUCTIONIn studies of the poten
- Page 108 and 109:
INTRODUCTIONSubstances investigated
- Page 110 and 111:
Table 9 : Outcome of yeast cell wal
- Page 112 and 113:
INTRODUCTIONFurthermore, cholestyra
- Page 114 and 115:
INTRODUCTIONwall peptidoglycans and
- Page 116 and 117:
INTRODUCTIONII. BIOLOGICAL DETOXIFI
- Page 118 and 119:
INTRODUCTIONdecrease in toxin-conce
- Page 120 and 121:
INTRODUCTIONCONCLUSIONPrevention an
- Page 122 and 123:
TRAVAILEXPERIMENTAL90
- Page 124 and 125:
TRAVAIL EXPERIMENTALtoxicité gén
- Page 126 and 127:
TRAVAIL EXPERIMENTALRESUME DES ETUD
- Page 128 and 129:
These are not the final page number
- Page 130 and 131:
These are not the final page number
- Page 132 and 133:
These are not the final page number
- Page 134 and 135:
These are not the final page number
- Page 136 and 137:
These are not the final page number
- Page 138 and 139:
These are not the final page number
- Page 140 and 141:
TRAVAIL EXPERIMENTALChronic ingesti
- Page 142 and 143:
TRAVAIL EXPERIMENTALINTRODUCTIONMyc
- Page 144 and 145:
TRAVAIL EXPERIMENTALMATERIAL & METH
- Page 146 and 147:
TRAVAIL EXPERIMENTALthrough a grade
- Page 148 and 149:
Figure 5ABCDVilli height (µm)5432a
- Page 150 and 151:
TRAVAIL EXPERIMENTALRESULTS1) Histo
- Page 152 and 153:
Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
- Page 154 and 155:
TRAVAIL EXPERIMENTAL3) Intestinal i
- Page 156 and 157:
TRAVAIL EXPERIMENTALtreated group t
- Page 158 and 159:
TRAVAIL EXPERIMENTALThe potencial e
- Page 160 and 161:
TRAVAIL EXPERIMENTALQuantification
- Page 162 and 163:
Figure 10 :(a) Réaction de deesté
- Page 164 and 165:
TRAVAIL EXPERIMENTALrévélé de l
- Page 166 and 167:
TRAVAIL EXPERIMENTALABSTRACTFumonis
- Page 168 and 169:
TRAVAIL EXPERIMENTALintestinal leve
- Page 170 and 171:
TRAVAIL EXPERIMENTAL3) Experimental
- Page 172 and 173:
TRAVAIL EXPERIMENTALthe importance
- Page 174 and 175:
Figure 11 : Effects of FB1 and HFB1
- Page 176 and 177:
Table 15 : Effects of FB1 and HFB1
- Page 178 and 179:
Table 17 : Effects of FB1 and HFB1
- Page 180 and 181:
TRAVAIL EXPERIMENTALDISCUSSIONThe a
- Page 182 and 183:
TRAVAIL EXPERIMENTALassociated lymp
- Page 184 and 185:
TRAVAIL EXPERIMENTALHartinger et al
- Page 186 and 187:
Figure 13 :(a) Transformation par v
- Page 188 and 189:
Figure 14 :Illustrations de la proc
- Page 190 and 191:
Figure 15 :Plan expérimental de la
- Page 192 and 193:
TRAVAIL EXPERIMENTAL4) Analyses du
- Page 194 and 195:
TRAVAIL EXPERIMENTAL9) Analyses sta
- Page 196 and 197:
TRAVAIL EXPERIMENTALRESULTATS1) Eff
- Page 198 and 199:
TRAVAIL EXPERIMENTAL2) Effet des ag
- Page 200 and 201:
TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
- Page 202 and 203:
TRAVAIL EXPERIMENTALL’exposition
- Page 204 and 205:
Figure 21 : Effet de l’exposition
- Page 206 and 207: 1,41,21,00,80,60,40,20,0IL‐8a,cc
- Page 208 and 209: TRAVAIL EXPERIMENTALDISCUSSIONLes o
- Page 210 and 211: TRAVAIL EXPERIMENTALœdèmes pulmon
- Page 212 and 213: DISCUSSIONGENERALE160
- Page 214 and 215: DISCUSSION GENERALEDans ce travail
- Page 216 and 217: DISCUSSION GENERALEdes vaches laiti
- Page 218 and 219: Tableau 24 : Analyse de denrées ag
- Page 220 and 221: DISCUSSION GENERALEet al., 2008b).
- Page 222 and 223: DISCUSSION GENERALE• une réactio
- Page 224 and 225: DISCUSSION GENERALE2. Les systèmes
- Page 226 and 227: DISCUSSION GENERALEMycoplasma agala
- Page 228 and 229: DISCUSSION GENERALEoptimale. Les au
- Page 230 and 231: DISCUSSION GENERALEsphingomyéline
- Page 232 and 233: DISCUSSION GENERALEsignalisation ce
- Page 234 and 235: DISCUSSION GENERALEL’IMMUNITÉ IN
- Page 236 and 237: DISCUSSION GENERALEplus spécifique
- Page 238 and 239: DISCUSSION GENERALEsouligner que le
- Page 240 and 241: DISCUSSION GENERALELA CARBOXYLESTER
- Page 242 and 243: DISCUSSION GENERALEde HFB1. Toutefo
- Page 244 and 245: CONCLUSIONS184
- Page 246 and 247: CONCLUSIONSLes effets d’expositio
- Page 248 and 249: CONCLUSIONSest utilisée lorsque la
- Page 250 and 251: REFERENCES BIBLIOGRAPHIQUESAABDEL-W
- Page 252 and 253: REFERENCES BIBLIOGRAPHIQUESBHANDARI
- Page 254 and 255: REFERENCES BIBLIOGRAPHIQUESCASADO,
- Page 258 and 259: REFERENCES BIBLIOGRAPHIQUESETIENNE,
- Page 260 and 261: REFERENCES BIBLIOGRAPHIQUESGRENIER,
- Page 262 and 263: REFERENCES BIBLIOGRAPHIQUESHERZALLA
- Page 264 and 265: REFERENCES BIBLIOGRAPHIQUESKERKADI,
- Page 266 and 267: REFERENCES BIBLIOGRAPHIQUESKUMAR, M
- Page 268 and 269: REFERENCES BIBLIOGRAPHIQUESMARZOCCO
- Page 270 and 271: REFERENCES BIBLIOGRAPHIQUESODHAV, B
- Page 272 and 273: REFERENCES BIBLIOGRAPHIQUESPFOHL-LE
- Page 274 and 275: REFERENCES BIBLIOGRAPHIQUESREFAI, M
- Page 276 and 277: REFERENCES BIBLIOGRAPHIQUESSCHWARTZ
- Page 278 and 279: REFERENCES BIBLIOGRAPHIQUESSWANSON,
- Page 280 and 281: REFERENCES BIBLIOGRAPHIQUESVEKIRU,
- Page 282 and 283: REFERENCES BIBLIOGRAPHIQUESYAN, D.,
Change language