REFERENCES BIBLIOGRAPHIQUESODHAV, B., ADAM, J. K. & BHOOLA, K. D. 2008. Modulating effects of fumonisin B1 and ochratoxin Aon <strong>le</strong>ukocytes and mess<strong>en</strong>ger cytokines of the human imm<strong>un</strong>e system. InternationalImm<strong>un</strong>opharma<strong>co</strong>logy, 8, 799-809.OGIDO, R., OLIVEIRA, C. A. F., LEDOUX, D. R., ROTTINGHAUS, G. E., CORREA, B., BUTKERAITIS, P., REIS,T. A., GONCALES, E. & ALBUQUERQUE, R. 2004. Effects of prolonged administration ofaflatoxin B-1 and fumonisin B-1 in laying Japanese quail. Poultry Sci<strong>en</strong>ce, 83, 1953-1958.OGUZ, H., HADIMLI, H. H., KURTOGLU, V. & ERGANIS, O. 2003. Evaluation of humoral imm<strong>un</strong>ity ofbroi<strong>le</strong>rs during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure. Revue DeMedecine Veterinaire, 154, 483-486.OGUZ, H. & KURTOGLU, V. 2000. Effect of clinoptilolite on performance of broi<strong>le</strong>r chick<strong>en</strong>s duringexperim<strong>en</strong>tal aflatoxi<strong>co</strong>sis. British Poultry Sci<strong>en</strong>ce, 41, 512-517.OGUZ, H., KURTOGLU, V. & COSKUN, B. 2000. Prev<strong>en</strong>tive efficacy of clinoptilolite in broi<strong>le</strong>rs duringchronic aflatoxin (50 and 100 ppb) exposure. Research in Veterinary Sci<strong>en</strong>ce, 69, 197-201.ORSI, R. B., OLIVEIRA, C. A. F., DILKIN, P., XAVIER, J. G., DIREITO, G. M. & CORREA, B. 2007. Effects oforal administration of aflatoxin B-1 and fumonisin B-1 in rabbits (Oryctolagus c<strong>un</strong>iculus).Chemi<strong>co</strong>-Biological Interactions, 170, 201-208.ORTATATLI, M. & OGUZ, H. 2001. Ameliorative effects of dietary clinoptilolite on pathologicalchanges in broi<strong>le</strong>r chick<strong>en</strong>s during aflatoxi<strong>co</strong>sis. Research in Veterinary Sci<strong>en</strong>ce, 71, 59-66.ORTATATLI, M., OGUZ, H., HATIPOGLU, F. & KARAMAN, M. 2005. Evaluation of pathological changesin broi<strong>le</strong>rs during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure. Research inVeterinary Sci<strong>en</strong>ce, 78, 61-68.OSWALD, I. P. & COMERA, C. 1998. Imm<strong>un</strong>otoxicity of my<strong>co</strong>toxins. Revue De Medecine Veterinaire,149, 585-590.OSWALD, I. P., DESAUTELS, C., LAFFITTE, J., FOURNOUT, S., PERES, S. Y., ODIN, M., LE BARS, P., LEBARS, J. & FAIRBROTHER, J. M. 2003. My<strong>co</strong>toxin fumonisin B-1 increases intestinal<strong>co</strong>lonization by pathog<strong>en</strong>ic Escherichia <strong>co</strong>li in pigs. Applied and Environm<strong>en</strong>tal Microbiology,69, 5870-5874.OSWALD, I. P., DOZOIS, C. M., BARLAGNE, R., FOURNOUT, S., JOHANSEN, M. V. & BOGH, H. O. 2001.Cytokine mRNA expression in pigs infected with Schistosoma japonicum. Parasitology, 122,299-307.PPALENCIA, E., TORRES, O., HAGLER, W., MEREDITH, F. I., WILLIAMS, L. D. & RILEY, R. T. 2003. Totalfumonisins are reduced in tortillas using the traditional nixtamalization method of mayan<strong>co</strong>mm<strong>un</strong>ities. Journal of Nutrition, 133, 3200-3203.PAPADAKIS, K. A. & TARGAN, S. R. 2000. Ro<strong>le</strong> of cytokines in the pathog<strong>en</strong>esis of inflammatory boweldisease. Annual Review of Medicine, 51, 289-298.PAPAIOANNOU, D. S., KYRIAKIS, S. C., PAPASTERIADIS, A., ROUMBIES, N., YANNAKOPOULOS, A. &ALEXOPOULOS, C. 2002. Effect of in-feed inclusion of a natural zeolite (clinoptilolite) oncertain vitamin, macro and trace e<strong>le</strong>m<strong>en</strong>t <strong>co</strong>nc<strong>en</strong>trations in the blood, liver and kidneytissues of sows. Research in Veterinary Sci<strong>en</strong>ce, 72, 61-68.PARK, D. L. 1993. Perspectives on My<strong>co</strong>toxin De<strong>co</strong>ntamination Procedures. Food Additives andContaminants, 10, 49-60.PARK, D. L., LEE, L. S., PRICE, R. L. & POHLAND, A. E. 1988. Review of the De<strong>co</strong>ntamination ofAflatoxins by Ammoniation - Curr<strong>en</strong>t Status and Regulation. Journal of the Association ofOfficial Analytical Chemists, 71, 685-703.PARK, D. L., LOPEZGARCIA, R., TRUJILLO, S. & PRICE, R. L. 1995. Reduction of Risks Associated withFumonisin Contamination in Corn. Abstracts of Papers of the American Chemical Society, 209,132-AGFD.209
REFERENCES BIBLIOGRAPHIQUESPARK, D. L., RUA, S. M., MIROCHA, C. J., ABDALLA, E. & CONG, Y. W. 1992. Mutag<strong>en</strong>ic Pot<strong>en</strong>tials ofFumonisin Contaminated Corn Following Ammonia De<strong>co</strong>ntamination Procedure.My<strong>co</strong>pathologia, 117, 105-108.PARK, J. W., SCOTT, P. M., LAU, B. P. Y. & LEWIS, D. A. 2004. Analysis of heat-processed <strong>co</strong>rn foods forfumonisins and bo<strong>un</strong>d fumonisins. Food Additives and Contaminants Part a-ChemistryAnalysis Control Exposure & Risk Assessm<strong>en</strong>t, 21, 1168-1178.PARLAT, S. S., OZCAN, M. & OGUZ, H. 2001. Biological suppression of aflatoxi<strong>co</strong>sis in Japanese quail(Coturnix <strong>co</strong>turnix japonica) by dietary addition of yeast (Saccharomyces cerevisiae).Research in Veterinary Sci<strong>en</strong>ce, 71, 207-211.PARLAT, S. S., YILDIZ, A. O. & OGUZ, H. 1999. Effect of clinoptilolite on performance of Japanese quail(Coturnix <strong>co</strong>turnix japonica) during experim<strong>en</strong>tal aflatoxi<strong>co</strong>sis. British Poultry Sci<strong>en</strong>ce, 40,495-500.PASTEINER, S. 1994. My<strong>co</strong>toxins in animal husbandry. In: Biomin GTI Ges St. Pölt<strong>en</strong>.PASTER, N., BARKAIGOLAN, R. & PADOVA, R. 1985. Effect of Gamma-Radiation on OchratoxinProduction by the F<strong>un</strong>gus Aspergillus-Ochraceus. Journal of the Sci<strong>en</strong>ce of Food andAgriculture, 36, 445-449.PATERSON, R. R. M. & LIMA, N. 2009. How will climate change affect my<strong>co</strong>toxins in food? FoodResearch International, 43, 1902-1914.PATTERSON, D. S. P., SHREEVE, B. J., ROBERTS, B. A., BERRETT, S., BRUSH, P. J., GLANCY, E. M. &KROGH, P. 1981. Effect on Calves of Bar<strong>le</strong>y Naturally Contaminated with Ochratoxin-a andGro<strong>un</strong>dnut Meal Contaminated with Low Conc<strong>en</strong>trations of Aflatoxin-B-1. Research inVeterinary Sci<strong>en</strong>ce, 31, 213-218.PEARSON, T. C., WICKLOW, D. T. & PASIKATAN, M. C. 2004. Reduction of aflatoxin and fumonisin<strong>co</strong>ntamination in yellow <strong>co</strong>rn by high-speed dual-wave<strong>le</strong>ngth sorting. Cereal Chemistry, 81,490-498.PEIRSON, S. N., BUTLER, J. N. & FOSTER, R. G. 2003. Experim<strong>en</strong>tal validation of novel and<strong>co</strong>nv<strong>en</strong>tional approaches to quantitative real-time PCR data analysis. Nuc<strong>le</strong>ic Acids Research,31.PELTONEN, K., EL-NEZAMI, H., HASKARD, C., AHOKAS, J. & SALMINEN, S. 2001. Aflatoxin B-1 bindingby dairy strains of lactic acid bacteria and bifidobacteria. Journal of Dairy Sci<strong>en</strong>ce, 84, 2152-2156.PESTKA, J. J. 2003. Deoxyniva<strong>le</strong>nol-induced IgA production and IgA nephropathy-aberrant mu<strong>co</strong>salimm<strong>un</strong>e response with systemic repercussions. Toxi<strong>co</strong>logy Letters, 140, 287-295.PESTKA, J. J. 2010. Deoxyniva<strong>le</strong>nol-Induced Proinflammatory G<strong>en</strong>e Expression: Mechanisms andPathological Sequelae. Toxins, 2, 1300-1317.PESTKA, J. J. & SMOLINSKI, A. T. 2005. Deoxyniva<strong>le</strong>nol: Toxi<strong>co</strong>logy and pot<strong>en</strong>tial effects on humans.Journal of Toxi<strong>co</strong>logy and Environm<strong>en</strong>tal Health-Part B-Critical Reviews, 8, 39-69.PESTKA, J. J., TAI, J. H., WITT, M. F., DIXON, D. E. & FORSELL, J. H. 1987. Suppression of Imm<strong>un</strong>e-Response in the B6c3f1 Mouse after Dietary Exposure to the Fusarium My<strong>co</strong>toxinsDeoxyniva<strong>le</strong>nol (Vomitoxin) and Zeara<strong>le</strong>none. Food and Chemical Toxi<strong>co</strong>logy, 25, 297-304.PESTKA, J. J. & ZHOU, H. R. 2000. Inter<strong>le</strong>ukin-6-defici<strong>en</strong>t mice refractory to IgA dysregulation but notanorexia induction by vomitoxin (d eoxyniva<strong>le</strong>nol) ingestion. Food and Chemical Toxi<strong>co</strong>logy,38, 565-575.PESTKA, J. J., ZHOU, H. R., MOON, Y. & CHUNG, Y. J. 2004. Cellular and mo<strong>le</strong>cular mechanisms forimm<strong>un</strong>e modulation by deoxyniva<strong>le</strong>nol and other trichothec<strong>en</strong>es: <strong>un</strong>raveling a paradox.Toxi<strong>co</strong>logy Letters, 153, 61-73.PETTERSSON, H. 2004. Controlling my<strong>co</strong>toxins in animal feed. In: MAGEN, N. & OLSEN, M. (eds.)My<strong>co</strong>toxins in food, detection and <strong>co</strong>ntrol. Woodhead publishing Ltd and CRC press LLC.PFOHL-LESZKOWICZ, A. & MANDERVILLE, R. A. 2007. Ochratoxin A : an overview on toxicity andcarcinog<strong>en</strong>icity in animals and humans. Mo<strong>le</strong>cular Nutrition and Food Research, 51, 61-99.210
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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Tableau 24 : Analyse de denrées ag
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