Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

146
WISSENSCHAFTLICHER ERGEBNISBERICHT | TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH
• 7. Ciesek S, Friesland M, Steinmann J, Becker B, Wedemeyer H,
Manns MP, Pietschmann T & Steinmann E (2010) How stable is the
hepatitis C virus (HCV)? Environmental stability of HCV and its
susceptibility to chemical biocides. Journal of Infectious Diseases
201(12), 1859-1866.
• 8. Lemon SM, McKeating JA, Pietschmann T, Frick DN, Glenn JS,
Tellinghuisen TL, Symons J & Furman PA (2010) Development of
novel therapies for hepatitis C. Antiviral Research 86(1), 79-92
(Review).
• 9. Bankwitz D, Steinmann E, Bitzegeio J, Ciesek S, Friesland M,
Herrmann E, Zeisel MB, Baumert TF, Keck ZY, Foung SK, Pecheur
EI & Pietschmann T (2010) Hepatitis C virus hypervariable region 1
modulates receptor interactions, conceals the CD81 binding site, and
protects conserved neutralizing epitopes. Journal of Virology 84(11),
5751-5763.
• 10. Stegmann KA, Bjorkstrom NK, Veber H, Ciesek S, Riese P,
Wiegand J, Hadem J, Suneetha PV, Jaroszewicz J, Wang C, Schlaphoff
V, Fytili P, Cornberg M, Manns MP, Geffers R, Pietschmann T,
Guzman CA, Ljunggren HG & Wedemeyer H (2010) Interferon-alphainduced
TRAIL on natural killer cells is associated with control of
hepatitis C virus infection. Gastroenterology 138(5), 1885-1897.
• 11. Ciesek S, Steinmann E, Iken M, Ott M, Helfritz FA,
Wappler I, Manns MP, Wedemeyer H & Pietschmann T (2010)
Glucocorticosteroids increase cell entry by hepatitis C virus.
Gastroenterology 138(5), 1875-1884.
• 12. von Hahn T, Steinmann E, Ciesek S & Pietschmann T (2010)
Know your enemy: translating insights about the molecular biology
of hepatitis C virus into novel therapeutic approaches. Expert Review
on Gastroenterology & Hepatology 4(1), 63-79.
• 13. Steinmann J, Becker B, Bischoff B, Paulmann D, Friesland M,
Pietschmann T, Steinmann E (2010) Virucidal activity of 2 alcoholbased
formulations proposed as hand rubs by the World Health
Organization. American Journal of Infection Control 38(1), 66-68.
• 14. Haid S, Windisch MP, Bartenschlager R & Pietschmann T (2010)
Mouse-specifi c residues of claudin-1 limit hepatitis C virus genotype
2a infection in a human hepatocyte cell line. Journal of Virology
84(2), 964-975.
Forschungsgruppe um Prof. Sparwasser
• 1. Hackl D, Loschko J, Sparwasser T, Reindl W & Krug A (2011)
Activation of dendritic cells via TLR7 reduces Foxp3 expression
and suppressive function in induced Tregs. European Journal of
Immunology (in press).
• 2. Paust HJ, Ostmann A, Erhardt A, Turner JE, Mittrücker HW,
Sparwasser T, Panzer U & Tiegs G (2011) Regulatory T cells control
the Th1 immune response in murine crescentic glomerulonephritis.
Kidney International (in press).
• 3. Sawa S, Lochner M, Satoh-Takayama N, Gaboriau-Routhiau V,
Dulauroy S, Bérard M, Kleinschek M, Cerf-Bensussan N, Cua D, Di
Santo JP & Eberl G (2011) RORgt+ innate lymphoid cells regulate
intestinal homeostasis by integrating negative signals from the
symbiotic microbiota. Nature Immunology Feb 20 [Epub ahead of
print].
• 4. Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T,
Huehnn J, Kühl AA, Loddenkemper C, Jacobs T & Breloer M (2011)
Strongyloides ratti infection induces expansion of Foxp3+ regulatory
T cells that interfere with immune response and parasite clearance
in BALB/c mice. Journal of Immunology Feb 18 [Epub ahead of print].
• 5. Hadis U, Wahl B, Schulz O, Schippers A, Wagner N, Müller W,
Sparwasser T, Förster R & Pabst O (2011) Cooperation of lymph nodes
and intestinal lamina propria in FoxP3+ regulatory T cell mediated
intestinal tolerance. Immunity 34(2), 237-246.
• 6. Stagg J, Divisekera U, Duret H, Sparwasser T, Teng MW, Darcy PK
& Smyth MJ (2011) CD73-defi cient mice have increased anti-tumor
immunity and are resistant to experimental metastasis. Cancer
Research Feb 3 [Epub ahead of print].
• 7. Ohnmacht C*, Marques R*, Presley L*, Sawa S*, Lochner M* &
Eberl G (2011) Intestinal microbiota, evolution of the immune system
and the bad reputation of pro-infl ammatory immunity. Cellular
Microbiology Jan 28 [Epub ahead of print] Review.
• 8. Mayer CT, Floess S, Baru AM, Lahl K, Huehn J & Sparwasser T
(2011) CD8+Foxp3+ T cells share developmental and phenotypic
features with classical CD4+Foxp3+ regulatory T cells but lack
potent suppressive activity. European Journal of Immunology 41(3),
716-725.
• 9. Lahl K & Sparwasser T (2011) In vivo depletion of Foxp3+ Tregs
using the DEREG mouse model. Methods in Molecular Biology 707,
157-172 Review.
• 10. Berod L, Heinemann C, Heink S, Escher A, Stadelmann C, Drube
S, Wetzker R, Norgauer J & Kamradt T (2011) PI3K defi ciency delays
the onset of experimental autoimmune encephalomyelitis and
ameliorates its clinical outcome. European Journal of Immunology
41(3), 833-844.
• 11. Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford
AR, ShahinianA, Lang PA, Lang KS, Morre M, Assouline B, Lahl K,
Sparwasser T, Tedder TF, Paik J, DePinho RA, Basta S, Ohashi PS
& Mak TW (2011) IL-7 engages multiple mechanisms to overcome
chronic viral infection and limit organ pathology. Cell 144(4), 601-
613.
• 12. Dietze KK, Zelinskyy G, Gibbert K, Schimmer S, Francois S,
Myers L, Sparwasser T, Hasenkrug KJ & Dittmer U (2011) Transient
depletion of regulatory T cells in transgenic mice reactivates virusspecifi
c CD8+ T cells and reduces chronic retroviral set points.
Proceedings of the National Academy of Sciences U S A 108(6), 2420-
2425.
• 13. Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F,
Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hunig
T, Serfl ing E & Bodor J (2011) Regulatory T cells facilitate the
nuclear accumulation of inducible cAMP early repressor (ICER) and
suppress nuclear factor of activated T cell c1 (NFATc1). Proceedings
of the National Academy of Sciences U S A 108(6), 2480-2485.
• 14. Lochner M, Bérard M, Sawa S, Hauer S, Gaboriau-Routhiau V,
Fernandez F, Bousso P, Cerf-Bensussan N & Eberl G (2011) Restricted
microbiota and absence of cognate TCR antigen leads to an
unbalanced generation of Th17 cells. Journal of Immunology 186(3),
1531-1537 (Epub 2010 Dec 22)
• 15. Lochner M, Ohnmacht C, Presley L, Bruhns P, Si-Tahar M, Sawa
S & Eberl G (2011) Microbiota-induced tertiary lymphoid tissues
aggravate infl ammatory disease in the absence of RORgt and LTi
cells. Journal of Experimental Medicine 208(1), 125-134 (Epub 20 Dec
2010)
• 16. Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, de
Labastida F, Sparwasser T, Hill GR & Engwerda CR (2010) CD4+
natural regulatory T cells prevent experimental cerebral malaria via
CTLA-4 when expanded in vivo. PLoS Pathogens 6(12), e1001221.
• 17. Engel, D, Koscielny A, Wehner S, Maurer J, Schiwon M, Franken
L, Schumak B, Limmer A, Sparwasser T, Hirner A, Knolle P, Kalff J
& Kurts C (2010) Th1 memory cells disseminate postoperative ileus
over the entire intestinal tract. Nature Medicine 16(12), 1407-1413.
• 18. Hubert S, Rissiek B, Klages K, Hühn J, Sparwasser T, Haag F,
Koch-Nolte F, Boyer O, Seman M & Adriouch S (2010) Extracellular
NAD+ shapes the Foxp3 + regulatory T cell compartment through
the ART2/P2X7 pathway. Journal of Experimental Medicine 207(12),
2561-2568.