Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

• Xue,X., Tomasch,J., Sztajer,H., & Wagner-Döbler,I. (2010) The delta
subunit of RNA polymerase, RpoE, is a global modulator of Streptococcus
mutans environmental adaptation. Journal of Bacteriology
192, 5081-5092.
• Leonhäuser,J., Wang,W., Deckwer,W.-D., & Wagner-Döbler,I. (2011)
Functioning of the mercury resistance operon at extremely high
Hg(II) loads in a chemostat: a proteome analysis. Journal of Biotechnology,
in press
Abt. für Genregulation und Differenzierung |
Prof. Dr. Hansjörg Hauser
• Badar,M., Hemmen,K., Nimtz,M., Stieve,M., Stiesch,M., Lenarz,T.,
Hauser,H., Möllmann,U., Vogt,S., Schnabelrauch,M., & Müller,P.P.*.
(2010) Evaluation of madurahydroxylactone as a slow release antibacterial
implant coating. Open Biomedical Engineering Journal 4,
263-270.
• Becker,J., Pavlakovic,H., Ludewig,F., Wilting,F., Weich,H.A.*.,
Albuquerque,R., Ambati,J., & Wilting,J. (2010) Neuroblastoma progression
correlates with downregulation of the lymphangiogenesis
inhibitor sVEGFR-2. Clinical Cancer Research 16, 1431-1441.
• Bergmann,A., Ahmad,S., Cudmore,M., Gruber,A.D., Wittschen,P.,
Lindenmaier,W., Christofori,G., Gross,V., Gonzalves,A.C., Grone,H.J.,
Ahmed,A., & Weich,H.A.*. (2010) Reduction of circulating soluble
Flt-1 alleviates preeclampsia-like symptoms in a mouse model.
Journal of Cellular and Molecular Medicine 14, 1857-1867.
• Charbord,P., Livne,E., Gross,G., Haupl,T., Neves,N.M., Marie,P.,
Bianco,P., & Jorgensen,C. (2010) Human bone marrow mesenchymal
stem cells: a systematic reappraisal via the genostem experience.
Stem Cell Reviews and Reports 7, 32-42.
• Cohen-Haguenauer,O., Creff,N., Cruz,P., Tunc,C., Aiuti,A., Baum,C.,
Bosch,F., Blomberg,P., Cichutek,K., Collins,M., Danos,O., Dehaut,F.,
Federspiel,M., Galun,E., Garritsen,H., Hauser,H., Hildebrandt,M.,
Klatzmann,D., Merten,O.W., Montini,E., O’Brien,T., Panet,A.,
Rasooly,L., Scherman,D., Schmidt,M., Schweitzer,M., Tiberghien,P.,
Vandendriessche,T., Ziehr,H., Yla-Herttuala,S., von,K.C., Gahrton,G.,
& Carrondo,M. (2010) Relevance of an academic GMP Pan-European
vector infra-structure (PEVI). Current Gene Therapy 10, 414-422.
• Coroadinha,A.S., Gama-Norton,L., Amaral,A.I., Hauser,H., Alves,P.M.,
& Cruz,P.E. (2010) Production of retroviral vectors: review. Current
Gene Therapy 10, 456-473.
• Courties,G., Seiffart,V., Presumey,J., Escriou,V., Scherman,D.,
Zwerina,J., Ruiz,G., Zietara,N., Jablonska,J., Weiss,S., Hoffmann,A.,
Jorgensen,C., Apparailly,F., & Gross,G. (2010) In vivo RNAi-mediated
silencing of TAK1 decreases infl ammatory Th1 and Th17 cells
through targeting of myeloid cells. Blood 116, 3505-3516.
• Dietrich,N., Rohde,M., Geffers,R., Kroger,A., Hauser,H., Weiss,S., &
Gekara,N.O. (2010) Mast cells elicit proinfl ammatory but not type I
interferon responses upon activation of TLRs by bacteria. Proceeding
of the National Academy of Sciences of the United States of America
107, 8748-8753.
• Dittmar,K.E.*., Simann,M., Zghoul,N., Schön,O., Meyring,W.,
Hannig,H., Macke,L., Dirks,W.G., Miller,K., Garritsen,H.S.P., &
Lindenmaier,W. (2010) Quality of cell products: Authenticity, identity,
genomic stability and status of differentiation. Transfusion
Medicine and Hemotherapy 37, 57-64.
• Ehlert,N., Hoffmann,A., Luessenhop,T., Gross,G., Mueller,P.P.*.,
Stieve,M., Lenarz,T., & Behrens,P. (2010) Amino-modifi ed silica surfaces
effi ciently immobilize bone morphogenetic protein 2 (BMP2)
for medical purposes. Acta Biomaterialia 7, 1772-1779.
• Ehlert,N., Müller,P.P.*., Stieve,M., & Behrens,P. (2010) Immobilization
of alkaline phosphatase on modifi ed silica coatings. Microporous and
Mesoporous Materials 131, 51-57.
WISSENSCHAFTLICHER ERGEBNISBERICHT | Veröffentlichungen
• Gama-Norton,L., Herrmann,S., Schucht,R., Coroadinha,A.S., Low,R.,
Alves,P.M., Bartholomae,C.C., Schmidt,M., Baum,C., Schambach,A.,
Hauser,H., & Wirth,D. (2010) Retroviral vector performance in defi
ned chromosomal Loci of modular packaging cell lines. Human
Gene Therapy 21, 979-991.
149
• Garritsen,H.S., Macke,L., Meyring,W., Hannig,H., Pagelow,U.,
Wormann,B., Geffers,R., Dittmar,K.E.*., & Lindenmaier,W. (2010) Effi -
cient generation of clinical-grade genetically modifi ed dendritic cells
for presentation of multiple tumor-associated proteins. Trans fusion
50, 831-842.
• Kirschning,C.J., Dreher,S., Maass,B., Fichte,S., Schade,J., Koster,M.,
Noack,A., Lindenmaier,W., Wagner,H., & Boldicke,T. (2010) Generation
of anti-TLR2 intrabody mediating inhibition of macrophage
surface TLR2 expression and TLR2-driven cell activation. BMC Biotechnology
10, 31.
• Loew,R., Meyer,Y., Kuehlcke,K., Gama-Norton,L., Wirth,D., Hauser,H.,
Stein,S., Grez,M., Thornhill,S., Thrasher,A., Baum,C., & Schambach,A.
(2010) A new PG13-based packaging cell line for stable production of
clinical-grade self-inactivating gamma-retroviral vectors using targeted
integration. Gene Therapy 17, 272-280.
• Macke,L., Garritsen,H.S., Meyring,W., Hannig,H., Pagelow,U.,
Wormann,B., Piechaczek,C., Geffers,R., Rohde,M., Lindenmaier,W.,
& Dittmar,K.E.*. (2010) Evaluating maturation and genetic modifi -
cation of human dendritic cells in a new polyolefi n cell culture bag
system. Transfusion 50, 843-855.
• May,T., Butueva,M., Bantner,S., Markusic,D., Seppen,J.,
MacLeod,R.A., Weich,H., Hauser,H., & Wirth,D. (2010) Synthetic gene
regulation circuits for control of cell expansion. Tissue Engineering –
Part A 16, 441-452.
• Nehlsen,K., Herrmann,S., Zauers,J., Hauser,H., & Wirth,D. (2010)
Toxin-antitoxin based transgene expression in mammalian cells.
Nucleic Acids Research 38, e32.
• Pulverer,J.E., Rand,U., Lienenklaus,S., Kugel,D., Zietara,N., Kochs,G.,
Naumann,R., Weiss,S., Staeheli,P., Hauser,H., & Koster,M. (2010)
Temporal and spatial resolution of type I and III interferon responses
in vivo. Journal of Virology 84, 8626-8638.
• Roming,M., Lünsdorf,H., Dittmar,K.E.*., & Feldmann,C. (2010)
ZrO(HPO(4))(1-x)(FMN)(x): quick and easy synthesis of a nanoscale
luminescent biomarker. Angewandte Chemie International Edition
49, 632-637.
• Sandhu,U., Cebula,M., Behme,S., Riemer,P., Wodarczyk,C.,
Metzger,D., Reimann,J., Schirmbeck,R., Hauser,H., & Wirth,D. (2010)
Strict control of transgene expression in a mouse model for sensitive
biological applications based on RMCE compatible ES cells. Nucleic
Acids Research 39, e1.
• Schniedermann,J., Rennecke,M., Buttler,K., Richter,G., Stadtler,A.M.,
Norgall,S., Badar,M., Barleon,B., May,T., Wilting,J., & Weich,H.A.*.
(2010) Mouse lung contains endothelial progenitors with high capacity
to form blood and lymphatic vessels. BMC Cell Biology 11, 50.
• Schucht,R., Wirth,D., & May,T. (2010) Precise regulation of transgene
expression level and control of cell physiology. Cell Biology and
Toxicology 26, 29-42.
• Shahab-Osterloh,S., Witte,F., Hoffmann,A., Winkel,A., Laggies,S.,
Neumann,B., Seiffart,V., Lindenmaier,W., Gruber,A.D., Ringe,J.,
Haupl,T., Thorey,F., Willbold,E., Corbeau,P., & Gross,G. (2010) Mesenchymal
stem cell-dependent formation of heterotopic tendon-bone
insertions (osteotendinous junctions). Stem Cells 28, 1590-1601.
• Stammen,S., Schuller,F., Dietrich,S., Gamer,M., Biedendieck,R.,
& Jahn,D. (2010) Application of Escherichia coli phage K1E DNAdependent
RNA polymerase for in vitro RNA synthesis and in vivo
protein production in Bacillus megaterium. Applied Microbiology and
Biotechnology 88, 529-539.
• Stirnweiss,A., Ksienzyk,A., Klages,K., Rand,U., Grashoff,M.,
Hauser,H., & Kröger,A. (2010) IFN regulatory factor-1 bypasses IFNmediated
antiviral effects through viperin gene induction. Journal of
Immunology 184, 5179-5185.