Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

168 WISSENSCHAFTLICHER ERGEBNISBERICHT | Veröffentlichungen
• Dehn,R., Katsuyama,Y., Weber,A., Gerth,K., Jansen,R., Steinmetz,H.,
Höfl e,G., Müller,R., & Kirschning,A. (2011) Molecular basis of elansolid
biosynthesis: evidence for an unprecedented quinone methide
inititiated intramolecular Diels-Alder cycloaddition / macrolactonization.
Angewandte Chemie 50, 532-536.
• Huntley,S., Hamann,N., Wegener-Feldbrugge,S., Treuner-Lange,A.,
Kube,M., Reinhardt,R., Klages,S., Müller,R., Ronning,C.M.,
Nierman,W.C., & Sogaard-Andersen,L. (2011) Comparative genomic
analysis of fruiting body formation in Myxococcales. Molecular
Biology and Evolution 28, 1083-1097.
• Steinmetz,H., Gerth,K., Jansen,R., Schlager,N., Dehn,R., Reinecke,S.,
Kirschning,A., & Müller,R. (2011) Elansolid A, a unique macrolide antibiotic
from Chitinophaga sancti isolated as two stable atropisomers.
Angewandte Chemie International Edtion 50, 532-536.
• Wenzel,S.C. & Müller,R. (2011) Myxobacteria - Unique microbial
secondary metabolic factories. In: Comprehensive Natural Products
II: Chemistry and Biology, Elsevier Science & Technology, Oxford, pp.
189-222.
• Anderl,T., Nicolas,L., Munkemer,J., Baro,A., Sasse,F., Steinmetz,H.,
Jansen,R., Hofl e,G., Taylor,R.E., & Laschat,S. (2011) Gephyronic Acid,
a Missing Link between Polyketide Inhibitors of Eukaryotic Protein
Synthesis (Part II): Total Synthesis of Gephyronic Acid. Angewandte
Chemie International Edition, in press.
• Garcia,R., Pistorius,D., Stadler,M., & Müller,R. (2011) Fatty acid Related
Phylogeny of Myxobacteria as an Approach to Discover Polyunsaturated
Omega-3/6 Fatty Acids. Journal of Bacteriology, in press.
• Okanya,P.W., Mohr,K.I., Gerth,K., Jansen,R., & Müller,R. (2011) Marinoquinolines
A-F, Pyrroloquinolines from Ohtaekwangia kribbensis
(Bacteroidetes). Journal of Natural Products, in press.
• Pistorius,D., Ullrich,A., Lucas,S., Hartmann,R.W., Kazmaier,U., &
Müller,R. (2011) Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas
aeruginosa: Potential for Therapeutic Interference with
Pathogenicity. ChemBioChem, in press.
• Rachid,S., Huo,L., Herrmann,J., Stadler,M., Kopcke,B., Bitzer,J., &
Müller,R. (2011) Mining the cinnabaramide biosynthetic pathway to
generate novel proteasome inhibitors. ChemBioChem, in press.
• Zander,W., Gerth,K., Mohr,K.I., Kessler,W., Jansen,R., & Müller,R.
(2011) Roimatacene, an antibiotic against gram-negative bacteria
isolated from cystobacter Cb G35 (myxobacteria). Chemistry - A European
Journal, in press.
Abt. für Wirkstoff-Transport – HIPS | Prof. Dr. Claus-Michael Lehr
• Beisner,J., Dong,M., Taetz,S., Nafee,N., Griese,E.U., Schaefer,U.,
Lehr,C.-M., Klotz,U., & Murdter,T.E. (2010) Nanoparticle mediated
delivery of 2’-O-methyl-RNA leads to effi cient telomerase inhibition
and telomere shortening in human lung cancer cells. Lung Cancer
68, 346-354.
• Bur,M., Huwer,H., Muys,L., & Lehr,C.-M. (2010) Drug transport across
pulmonary epithelial cell monolayers: effects of particle size, apical
liquid volume, and deposition technique. Journal of Aerosol Medicine
and Pulmonary Drug Delivery 23, 119-127.
• Ciana,A., Meier,K., Daum,N., Gerbes,S., Veith,M., Lehr,C.-M., &
Minetti,G. (2010) A dynamic ratio of the alpha+ and alpha- isoforms
of the tight junction protein ZO-1 is characteristic of Caco-2 cells and
correlates with their degree of differentiation. Cell Biology International
34, 669-678.
• Collnot,E.M., Baldes,C., Schaefer,U.F., Edgar,K.J., Wempe,M.F., &
Lehr,C.-M. (2010) Vitamin E TPGS P-glycoprotein inhibition mechanism:
infl uence on conformational fl exibility, intracellular ATP levels,
and role of time and site of access. Molecular Pharmaceutics 7,
642-651.
• Gaschen,A., Lang,D., Kalberer,M., Savi,M., Geiser,T., Gazdhar,A.,
Lehr,C.-M., Bur,M., Dommen,J., Baltensperger,U., & Geiser,M. (2010)
Cellular responses after exposure of lung cell cultures to secondary
organic aerosol particles. Environmental Science and Technology 44,
1424-1430.
• Henning,A., Schneider,M., Nafee,N., Muijs,L., Rytting,E., Wang,X.,
Kissel,T., Grafahrend,D., Klee,D., & Lehr,C.-M. (2010) Infl uence of
particle size and material properties on mucociliary clearance from
the airways. Journal of Aerosol Medicine and Pulmonary Drug Delivery
23, 233-241.
• Henning,A., Hein,S., Schneider,M., Bur,M., & Lehr,C.-M. (2010) Pulmonary
drug delivery: medicines for inhalation. Handbook of Experimental
Pharmacology 171-192.
• Lehmann,A.D., Daum,N., Bur,M., Lehr,C.-M., Gehr,P., & Rothen-
Rutishauser,B.M. (2010) An in vitro triple cell co-culture model with
primary cells mimicking the human alveolar epithelial barrier. European
Journal of Pharmaceutics and Biopharmaceutics 77, 398-406.
• Leonard,F., Collnot,E.M., & Lehr,C.-M. (2010) A three-dimensional
coculture of enterocytes, monocytes and dendritic cells to model
infl amed intestinal mucosa in vitro. Molecular Pharmaceutics 7,
2103-2119.
• Melero,A., Lehr,C.-M., Schafer,U.F., & Garrigues,T.M. (2010) Wistar
rat skin as surrogate for human skin in nortriptyline hydrochloride
patch studies. International Journal of Pharmaceutics 384, 137-139.
• Muendoerfer,M., Schaefer,U.F., Koenig,P., Walk,J.S., Loos,P.,
Balbach,S., Eichinger,T., & Lehr,C.-M. (2010) Online monitoring of
transepithelial electrical resistance (TEER) in an apparatus for combined
dissolution and permeation testing. International Journal of
Pharmaceutics 392, 134-140.
• Neumeyer,A., Bukowski,M., Veith,M., Lehr,C.-M., & Daum,N. (2010)
Interaction of nanoparticles and cells - cellular uptake and cytotoxic
effects in vitro. In Modern Polymeric Materials for Environmental
Applications (Pielichowski,K., ed), pp. 239-246. Cracow.
• Philippi,C., Loretz,B., Schaefer,U.F., & Lehr,C.-M. (2010) Telomerase
as an emerging target to fi ght cancer - Opportunities and challenges
for nanomedicine. Journal of Controlled Release 146, 228-240.
• Reum,N., Fink-Straube,C., Klein,T., Hartmann,R.W.*., Lehr,C.-M., &
Schneider,M. (2010) Multilayer coating of gold nanoparticles with
drug-polymer coadsorbates. Langmuir 26, 16901-16908.
• Rytting,E., Bur,M., Cartier,R., Bouyssou,T., Wang,X., Kruger,M.,
Lehr,C.-M., & Kissel,T. (2010) In vitro and in vivo performance of
biocompatible negatively-charged salbutamol-loaded nanoparticles.
Journal of Controlled Release 141, 101-107.
• Santander-Ortega,M.J., Stauner,T., Loretz,B., Ortega-Vinuesa,J.L.,
Bastos-Gonzalez,D., Wenz,G., Schaefer,U.F., & Lehr,C.-M. (2010) Nanoparticles
made from novel starch derivatives for transdermal drug
delivery. Journal of Controlled Release 141, 85-92.
• Hahn,T., Hansen,S., Neumann,D., Kostka,K.-H., Lehr,C.-M., Muys,L.,
& Schaefer,U.F. (2011) Infrared densitometry: A fast and non-destructive
method for exact stratum corneum depth calculation for in vitro
tape-stripping. Skin Pharmacology and Physiology 23, 183-192.
• Hahn,T., Winkler,K., Lehr,C.-M., & Schäfer,U.F. (2011) Ointment bases
and the rate of water loss of the skin [Salbengrundlagen und die
Wasserabgaberate der Haut]. Deutsche Apotheker Zeitung 150, 59-62.
• Hansen,S., Selzer,D., Schaefer,U.F., & Kasting,G.B. (2011) An extended
database of keratin binding. Journal of Pharmaceutical Sciences
100, 1712-1726.
• Hein,S., Bur,M., Schaefer,U.F., & Lehr,C.-M. (2011) A new Pharmaceutical
Aerosol Deposition Device on Cell Cultures (PADDOCC) to
evaluate pulmonary drug absorption for metered dose dry powder
formulations. European Journal of Pharmacology and Biopharmacology
77, 132-138.