Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

• Nehlsen,K., Herrmann,S., Zauers,J., Hauser,H., & Wirth,D. (2010)
Toxin-antitoxin based transgene expression in mammalian cells.
Nucleic Acids Research 38, e32.
• Sandhu,U., Cebula,M., Behme,S., Riemer,P., Wodarczyk,C.,
Metzger,D., Reimann,J., Schirmbeck,R., Hauser,H., & Wirth,D. (2010)
Strict control of transgene expression in a mouse model for sensitive
biological applications based on RMCE compatible ES cells. Nucleic
Acids Research 39, e1.
• Schucht,R., Wirth,D., & May,T. (2010) Precise regulation of transgene
expression level and control of cell physiology. Cell Biology and
Toxicology 26, 29-42.
• Wirth,D., Gama-Norton,L., Schucht,R., Nehlsen,K., & Hauser,H. (2010)
Site-directed engineering of defi ned chromosomal sites for recombinant
protein and virus expression. BioPharm International 22, 32-39.
• Carrondo,M., Panet,M., Wirth,D., Coroadinha,A.S., Cruz,P., Falk,H.,
Schucht,R., Dupont,F., Geny-Fiamma,C., Merten,O.W., & Hauser,H.
(2011) Integrated strategy for the production of therapeutic retroviral
vectors. Human Gene Therapy 22, 370-379.
NG Chronische Infektionen und Krebs | Prof. Dr. Lars Zender
• Gurlevik,E., Woller,N., Struver,N., Schache,P., Kloos,A., Manns,M.P.,
Zender,L., Kuhnel,F., & Kubicka,S. (2010) Selectivity of oncolytic viral
replication prevents antiviral immune response and toxicity, but
does not improve antitumoral immunity. Molecular Therapy 18, 1972-
1982.
• Klawonn,F., Wüstefeld,T., & Zender,L. (2010) Statistical modelling for
data from experiments with short haripin RNAs. LNCS (Lecture Notes
in Computer Science (including subseries Lecture Notes in Artifi cial
Intelligence and Lecture Notes in Bioinformatics)) 6065, 79-90.
• Wuestefeld,T. & Zender,L. (2010) DLC1 and liver cancer: the Akt
connection. Gastroenterology 139, 1093-1096.
• Zender,L., Villanueva,A., Tovar,V., Sia,D., Chiang,D.Y., & Llovet,J.M.
(2010) Cancer gene discovery in hepatocellular carcinoma. Journal of
Hepatology 52, 921-929.
• Kühnel,F., Gürvelik,E., Wirth,T.C., Strüver,N., Malek,N.P., Müller-
Schilling,M., Manns,M.P., Carnero,A., Zender,L. & Kubicka,S. (2010)
Targeting of p53-transcriptional dysfunction by conditionally replicating
adenovirus is not limited by p53-homologues. Molecular
Therapie 18(5), 936-946
• Xu,M.Z., Chan,S.W., Liu,A.M., Wong,K.F., Fan,S.T., Chen,J., Poon,R.T.,
Zender,L., Lowe,S.W., Hong,W., & Luk,J.M. (2011) AXL receptor kinase
is a mediator of YAP-dependent oncogenic functions in hepatocellular
carcinoma. Oncogene 30(10), 1229-1240
• Sawey,E., Chanrion,M., Cai,C., Wu,G., Zhang,J., Zender,L., Zhao,A.,
Busuttil,R., Yee,H., Stein,L., French,D., Finn,R., Lowe,S. & Powers,S.
(2011) Identifi cation of a Therapeutic Strategy Targeting Amplifi ed
FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell 19(3),
347-358
Abt. für Molekulare Strukturbiologie | Prof. Dr. Dirk Heinz
• Brocker,M.J., Schomburg,S., Heinz,D.W.*, Jahn,D., Schubert,W.D., &
Moser,J. (2010) Crystal structure of the nitrogenase-like dark operative
protochlorophyllide oxidoreductase catalytic complex (ChlN/
ChlB)2. Journal of Biological Chemistry 285, 27336-27345.
• Carius,Y., Christian,H., Faust,A., Zander,U., Klink,B.U.*,
Kornberger,P., Kohring,G.W., Giffhorn,F., & Scheidig,A.J. (2010) Structural
insight into substrate differentiation of the sugar-metabolizing
enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D.
Journal of Biological Chemistry 285, 20006-20014.
WISSENSCHAFTLICHER ERGEBNISBERICHT | Veröffentlichungen
151
• Ferraris,D.M., Gherardi,E., Di,Y., Heinz,D.W.*, & Niemann,H. (2010)
Ligand-mediated dimerization of the Met receptor tyrosine kinase by
the bacterial invasion protein InIB. Journal of Molecular Biology 395,
522-532.
• Haffke,M., Menzel,A., Carius,Y., Jahn,D., & Heinz,D.W.* (2010) Structures
of the nucleotide-binding domain of the human ABCB6 transporter
and its complexes with nucleotides. Acta Crystallographica
Section D: Biological Crystallography 66, 979-987.
• Heinemann,I.U., Schulz,C., Schubert,W.D., Heinz,D.W.*, Wang,Y.G.,
Kobayashi,Y., Awa,Y., Wachi,M., Jahn,D., & Jahn,M. (2010) Structure
of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen
synthase in complex with the antibiotic alaremycin. Antimicrobial
Agents and Chemotherapy 54, 267-272.
• Heinz,D.W.*., Betzel,C., & Wilmanns,M. (2010) Highlight: of systems
and structures. Biological Chemistry 391, 717-718.
• Hertiani,T., Edrada-Ebel,R., Ortlepp,S., van Soest,R.W., de Voogd,N.J.,
Wray,V., Hentschel,U., Kozytska,S., Muller,W.E., & Proksch,P. (2010)
From anti-fouling to biofi lm inhibition: New cytotoxic secondary
metabolites from two Indonesian Agelas sponges. Bioorganic and
Medicinal Chemistry 18, 1297-1311.
• Ibrahim,S.R., Min,C.C., Teuscher,F., Ebel,R., Kakoschke,C., Lin,W.,
Wray,V., Edrada-Ebel,R., & Proksch,P. (2010) Callyaerins A-F and H,
new cytotoxic cyclic peptides from the Indonesian marine sponge
Callyspongia aerizusa. Bioorganic and Medicinal Chemistry 18, 4947-
4956.
• Kampfer,P., Busse,H.J., Tindall,B.J., Nimtz,M., & Grun-Wollny,I. (2010)
Nonomuraea rosea sp. nov. International Journal of Systematic and
Evolutionary Microbiology 60, 1118-1124.
• Klink,B.U., Barden,S., Heidler,T.V., Borchers,C., Ladwein,M.,
Stradal,T.B.*, Rottner,K., & Heinz,D.W.* (2010) Structure of Shigella
IpgB2 in complex with human RhoA: implications for the mechanism
of bacterial guanine nucleotide exchange factor mimicry. Journal of
Biological Chemistry 285, 17197-17208.
• Klink,B.U.* & Scheidig,A.J. (2010) New insight into the dynamic
properties and the active site architecture of H-Ras p21 revealed by
X-ray crystallography at very high resolution. BMC Structural Biology
10, 38.
• Klodmann,J., Sunderhaus,S., Nimtz,M., Jänsch,L., & Braun,H.P. (2010)
Internal architecture of mitochondrial complex I from Arabidopsis
thaliana. Plant Cell 22, 797-810.
• Layer,G., Reichelt,J., Jahn,D., & Heinz,D.W.* (2010) Structure and
function of enzymes in heme biosynthesis. Protein Science 19, 1137-
1161.
• Marin,M., Perez-Pantoja,D., Donoso,R., Wray,V., Gonzalez,B., &
Pieper,D.H.* (2010) Modifi ed 3-oxoadipate pathway for the biodegradation
of methylaromatics in Pseudomonas reinekei MT1. Journal of
Bacteriology 192, 1543-1552.
• Moghaddam,F.M., Farimani,M.M., Seirafi ,M., Taheri,S., Khavasi,H.R.,
Sendker,J., Proksch,P., Wray,V., & Edrada,R. (2010) Sesterterpenoids
and other constituents of Salvia sahendica. Journal of Natural Products
73, 1601-1605.
• Palme,O., Comanescu,G., Stoineva,I., Radel,S., Benes,E., Develter,D.,
Wray,V., & Lang,S. (2010) Sophorolipids from Candida bombicola: Cell
separation by ultrasonic particle manipulation. European Journal of
Lipid Science and Technology 112, 663-673.
• Rand,K., Noll,C., Schiebel,H.M., Kemken,D., Dulcks,T., Kalesse,M.,
Heinz,D.W.*, & Layer,G. (2010) The oxygen-independent coproporphyrinogen
III oxidase HemN utilizes harderoporphyrinogen as a
reaction intermediate during conversion of coproporphyrinogen III to
protoporphyrinogen IX. Biological Chemistry 391, 55-63.
• Solbak,S.M., Reksten,T.R., Wray,V., Bruns,K., Horvli,O., Raae,A.J.,
Henklein,P., Henklein,P., Roder,R., Mitzner,D., Schubert,U., &
Fossen,T. (2010) The intriguing cyclophilin A-HIV-1 Vpr interaction:
prolyl cis/trans isomerisation catalysis and specifi c binding. BMC
Structural Biology 10, 31.