• Khvedelidze,M., Mdzinarashvili,T., Partskhaladze,T., Nafee,N., Schaefer,U.F., Lehr,C.-M., & Schneider,M. (20<strong>11</strong>) Calorimetric and spectrophotometric investigation of PLGA nanoparticles and their complex with DNA. Journal of Thermal Analysis and Calorimetry 99, 337-348. • Maurer,F., Daum,N., Schaefer,U.F., Lehr,C.-M., & Bauer,P. (20<strong>11</strong>) Plant genetic factors for iron homeostasis affect iron bioavailability in Caco-2 cells. Food Research International 43, 1661-1665. • Patzelt,A., Richter,H., Knorr,F., Schafer,U., Lehr,C.-M., Dahne,L., Sterry,W., & Lademann,J. (20<strong>11</strong>) Selective follicular targeting by modifi cation of the particle sizes. Journal of Control Release 150, 45-48. • Schulze,C., Schaefer,U.F., Ruge,C.A., Wohlleben,W., & Lehr,C.-M. (20<strong>11</strong>) Interaction of metal oxide nanoparticles with lung surfactant protein A. European Journal of Pharmaceutics and Biopharmaceutics 77, 376-383. Abt. <strong>für</strong> Wirkstoff-Design und -Optimierung – HIPS | Prof. Dr. Rolf Hartmann • Gobbi,S., Zimmer,C.*., Belluti,F., Rampa,A., Hartmann,R.W.*., Recanatini,M., & Bisi,A. (<strong>2010</strong>) Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. Journal of Medicinal Chemistry 53, 5347-5351. • Haller,F., Moman,E., Hartmann,R.W.*., Adamski,J., & Mindnich,R. (<strong>2010</strong>) Molecular framework of steroid/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptorassociated retinol dehydrogenase. Journal of Molecular Biology 399, 255-267. • Hu,Q., Yin,L., Jagusch,C., Hille,U.E., & Hartmann,R.W.*. (<strong>2010</strong>) Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. Journal of Medicinal Chemistry 53, 5049-5053. • Hu,Q., Jagusch,C., Hille,U.E., Haupenthal,J., & Hartmann,R.W.*. (<strong>2010</strong>) Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP<strong>11</strong>B1 inhibitors for the treatment of prostate cancer. Journal of Medicinal Chemistry 53, 5749-5758. • Hu,Q., Negri,M., Olgen,S., & Hartmann,R.W. (<strong>2010</strong>) The role of fl uorine substitution in biphenyl methylene imidazole-type CYP17 inhibitors for the treatment of prostate carcinoma. ChemMedChem 5, 899-910. • Negri,M., Recanatini,M., & Hartmann,R.W.*. (<strong>2010</strong>) Insights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigation. PLoS ONE 5, e12026. • Oster,A., Hinsberger,S., Werth,R., Marchais-Oberwinkler,S., Frotscher,M., & Hartmann,R.W.*. (<strong>2010</strong>) Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogendependent diseases. Journal of Medicinal Chemistry 53, 8176-8186. • Oster,A., Klein,T., Werth,R., Kruchten,P., Bey,E., Negri,M., Marchais- Oberwinkler,S., Frotscher,M., & Hartmann,R.W.*. (<strong>2010</strong>) Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorganic and Medicinal Chemistry 18, 3494-3505. • Reum,N., Fink-Straube,C., Klein,T., Hartmann,R.W.*., Lehr,C.-M., & Schneider,M. (<strong>2010</strong>) Multilayer coating of gold nanoparticles with drug-polymer coadsorbates. Langmuir 26, 16901-16908. • Zimmer,C., Hafner,M., Zender,M., Ammann,D., Hartmann,R.W.*., & Vock,C.A. (<strong>2010</strong>) N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP<strong>11</strong>B2). Bioorganic and Medicinal Chemistry Letters 21, 186-190. WISSENSCHAFTLICHER ERGEBNISBERICHT | Veröffentlichungen 169 • Heinzerling,L., Hartmann,R.W.*., Frotscher,M., & Neumann,D. (20<strong>11</strong>) Predicting putative inhibitors of 17beta-HSD1. Molecular Informatics 29, 695-705. • Hille,U.E., Zimmer,C., Vock,C.A., & Hartmann,R.W.*. (20<strong>11</strong>) First selective CYP<strong>11</strong>B1 inhibitors for the treatment of cortisol-dependent diseases. ACS Medicinal Chemistry Letters 2, 2-6. • Marchais-Oberwinkler,S., Wetzel,M., Ziegler,E., Kruchten,P., Werth,R., Henn,C., Hartmann,R.W.*., & Frotscher,M. (20<strong>11</strong>) New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases. Journal of Medicinal Chemistry 54, 534-547. • Oster,A., Klein,T., Henn,C., Werth,R., Marchais-Oberwinkler,S., Frotscher,M., & Hartmann,R.W.*. (20<strong>11</strong>) Bicyclic substituted hydroxyphenylmethanone type inhibitors of 17 beta-hydroxysteroid dehydrogenase Type 1 (17 beta-HSD1): the role of the bicyclic moiety. ChemMedChem 6, 476-487. • Stefanachi,A., Favia,A.D., Nicolotti,O., Leonetti,F., Pisani,L., Catto,M., Zimmer,C., Hartmann,R.W.*., & Carotti,A. (20<strong>11</strong>) Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Aromatase Inhibitors Selective over 17-alpha- Hydroxylase/C17-20 Lyase. Journal of Medicinal Chemistry 54, 1613- 1625. • Wetzel,M., Marchais-Oberwinkler,S., & Hartmann,R.W.*. (20<strong>11</strong>) 17beta-HSD2 inhibitors for the treatment of osteoporosis: Identifi cation of a promising scaffold. Bioorganic and Medicinal Chemistry 19, 807-815. • Yadav,M.R., Sabale,P.M., Giridhar,R., Zimmer,C., Haupenthal,J., & Hartmann,R.W.*. (20<strong>11</strong>) Synthesis of some novel androstanes as potential aromatase inhibitors. Steroids 76, 464-470.
FOKUS BERICHTE AUS DER FORSCHUNG SONDERBEITRÄGE Fotos von links nach rechts: Dr. Kurt Dittmar (vorne) und Dr. Werner Lindenmaier untersuchen Zellen <strong>für</strong> die Immuntherapie mittels konfokaler Laser-Scanning-Mikroskopie | Der BioTechnikum-Bus des BMBF während der von OMNILAB organisierten Biotech-Messe auf dem HZI-Campus | Während der Eröffnungszeremonie des Symposiums “Networking and Technology Transfer”, Bangkok, Thailand. In der 1. Reihe (von links) Dr. Peter Winter (InWEnt/GIZ), Prof. Dr. Visith Sitprija (Direktor des QSMI, Bangkok), Hr. Stefan Duppel (Stellvertretender Botschafter der Deutschen Botschaft in Bangkok), in der 2. Reihe links: Dr. Suparp Artjariyasripong (Vize-Governor von TISTR, Bangkok) Fotos: HZI, Scheibe (li) | OMNILAB (mi) | QSMI, Thai Red Cross (re)
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