Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

• Breitsprecher,D., Kiesewetter,A.K., Linkner,J., Vinzenz,M.,
Stradal,T.E.*., Small,J.V., Curth,U., Dickinson,R.B., & Faix,J. (2011)
Molecular mechanism of Ena/VASP-mediated actin-fi lament elongation.
Embo Journal 30, 456-467.
Frühere AG System- und Synthetische Biologie |
Prof. Dr. Vitor Martins dos Santos
• Fazzini,R.A., Preto,M.J., Quintas,A.C., Bielecka,A., Timmis,K.N.*.,
& dos Santos,V.A.P.M.*. (2010) Consortia modulation of the stress
response: proteomic analysis of single strain versus mixed culture.
Environmental Microbiology 12, 2436-2449.
• Koutinas,M., Kiparissides,A., Lam,M.-C., Silva-Rocha,R., de
Lorenzo,V., dos Santos,V.A.P.M.*., Pistikopoulos,E.N., & Mantalaris,A.
(2010) Combining genetic circuit and microbial growth kinetic models:
A challenge for biological modelling. Computer Aided Chemical
Engineering 28, 301-306.
• Koutinas,M., Lam,M.C., Kiparissides,A., Silva-Rocha,R., Godinho,M.,
Livingston,A.G., Pistikopoulos,E.N., de,L., V, Dos,S.V., & Mantalaris,A.
(2010) The regulatory logic of m-xylene biodegradation by Pseudomonas
putida mt-2 exposed by dynamic modelling of the principal
node Ps/Pr of the TOL plasmid. Environmental Microbiology 12, 1705-
1718.
• Lam,C.M.C., Puchalka,J., Diez,M.S., & dos Santos,V.A.P.M.*. (2010)
Exploring networks at the genome scale. European Biotechnology
Science and Industry News 9, 40-42.
Abt. für Mikrobielle Naturstoffe – HIPS & AG Mikrobielle Wirkstoffe
– HZI | Prof. Dr. Rolf Müller
• Arp,G., Bissett,A., Brinkmann,N., Cousin,S., de Beer,D., Friedl,T.,
Mohr,K.I.*., Neu,T.R., Reimer,A., Shiraishi,F., Stackebrandt,E.,
& Zippel,B. (2010) Tufa-forming biofi lms of German karstwater
streams: Microorganisms, exopolymers, hydrochemistry and calcifi -
cation. Geological Society Stecial Publication 336, 83-118.
•
Binz,T.M., Maffi oli,S.I., Sosio,M., Donadio,S., & Müller,R. (2010) Insights
into an unusual nonribosomal peptide synthetase biosynthesis:
identifi cation and characterization of the GE81112 biosynthetic
gene cluster. Journal of Biological Chemistry 285, 32710-32719.
• Brodmann,T., Janssen,D., Sasse,F., Irschik,H., Jansen,R., Müller,R., &
Kalesse,M. (2010) Isolation and synthesis of chivotriene, a chivosazole
shunt product from Sorangium cellulosum. European Journal of
Organic Chemistry 27, 5155-5159.
• Bulow,L., Nickeleit,I., Girbig,A.K., Brodmann,T., Rentsch,A.,
Eggert,U., Sasse,F., Steinmetz,H., Frank,R., Carlomagno,T.,
Malek,N.P., & Kalesse,M. (2010) Synthesis and biological characterization
of argyrin F. ChemMedChem 5, 832-836.
• Buntin,K., Irschik,H., Weissman,K.J., Luxenburger,E., Blöcker,H., &
Müller,R. (2010) Biosynthesis of thuggacins in myxobacteria: comparative
cluster analysis reveals basis for natural product structural
diversity. Chemistry and Biology 17, 342-356.
• Buntin,K., Weissman,K.J., & Müller,R. (2010) An unusual thioesterase
promotes isochromanone ring formation in ajudazol biosynthesis.
ChemBioChem 11, 1137-1146.
• Chai,Y., Pistorius,D., Ullrich,A., Weissman,K.J., Kazmaier,U., &
Müller,R. (2010) Discovery of 23 natural tubulysins from Angiococcus
disciformis An d48 and Cystobacter SBCb004. Chemistry and Biology
17, 296-309.
• Daum,M., Schnell,H.J., Herrmann,S., Gunther,A., Murillo,R.,
Müller,R., Bisel,P., Muller,M., & Bechthold,A. (2010) Functions of
genes and enzymes involved in phenalinolactone biosynthesis.
ChemBioChem 11, 1383-1391.
WISSENSCHAFTLICHER ERGEBNISBERICHT | Veröffentlichungen
167
• Erol,O., Schaberle,T.F., Schmitz,A., Rachid,S., Gurgui,C., El,O.M.,
Lohr,F., Kehraus,S., Piel,J., Müller,R., & Konig,G.M. (2010) Biosynthesis
of the myxobacterial antibiotic corallopyronin A. ChemBioChem
11, 1253-1265.
• Garcia,R., Gerth,K., Stadler,M., Dogma,I.J., Jr., & Müller,R. (2010)
Expanded phylogeny of myxobacteria and evidence for cultivation of
the ‘unculturables’. Molecular Phylogenetics and Evolution 57, 878-
887.
• Irschik,H., Kopp,M., Weissman,K.J., Buntin,K., Piel,J., & Müller,R.
(2010) Analysis of the sorangicin gene cluster reinforces the utility of
a combined phylogenetic/retrobiosynthetic analysis for deciphering
natural product assembly by trans-AT PKS. ChemBioChem 11, 1840-
1849.
• Khatri,Y., Hannemann,F., Ewen,K.M., Pistorius,D., Perlova,O.,
Kagawa,N., Brachmann,A.O., Müller,R., & Bernhardt,R. (2010) The
CYPome of Sorangium cellulosum So ce56 and identifi cation of
CYP109D1 as a new fatty acid hydroxylase. Chemistry and Biology 17,
1295-1305.
• Kunze,B., Reck,M., Dotsch,A., Lemme,A., Schummer,D., Irschik,H.,
Steinmetz,H., & Wagner-Döbler,I. (2010) Damage of Streptococcus
mutans biofi lms by carolacton, a secondary metabolite from the
myxobacterium Sorangium cellulosum. BMC Microbiology 10, 199.
• Li,Y., Weissman,K.J., & Müller,R. (2010) Insights into multienzyme
docking in hybrid PKS-NRPS megasynthetases revealed by heterologous
expression and genetic engineering. ChemBioChem 11, 1069-
1075.
• Menche,D., Li,P., & Irschik,H. (2010) Design, synthesis and biological
evaluation of simplifi ed analogues of the RNA polymerase inhibitor
etnangien. Bioorganic and Medicinal Chemistry Letters 20, 939-941.
• Nawrath,T., Gerth,K., Müller,R., & Schulz,S. (2010) The biosynthesis
of the aroma volatile 2-methyltetrahydrothiophen-3-one in the bacterium
Chitinophaga Fx7914. ChemBioChem 11, 1914-1919.
• Nawrath,T., Gerth,K., Müller,R., & Schulz,S. (2010) Volatile methyl
esters of medium chain length from the bacterium Chitinophaga
Fx7914. Chemistry and Biodiversity 7, 2228-2253.
• Nicolas,L., Anderl,T., Sasse,F., Steinmetz,H., Jansen,R., Höfl e,G.,
Laschat,S., & Taylor,R.E. (2010) Gephyronic Acid, a Missing Link between
Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I):
Structural Revision and Stereochemical Assignment of Gephyronic
Acid. Angewandte Chemie International Edition 50, 938-941.
• Rachid,S., Revermann,O., Dauth,C., Kazmaier,U., & Müller,R. (2010)
Characterization of a novel type of oxidative decarboxylase involved
in the biosynthesis of the styryl moiety of chondrochloren from an
acylated tyrosine. Journal of Biological Chemistry 285, 12482-12489.
• Vilchez,R., Lemme,A., Ballhausen,B., Thiel,V., Schulz,S., Jansen,R.,
Sztajer,H., & Wagner-Döbler,I. (2010) Streptococcus mutans inhibits
Candida albicans hyphal formation by the fatty acid signaling molecule
trans-2-decenoic acid (SDSF). ChemBioChem 11, 1552-1562.
• Weissmann,K.J. & Müller,R. (2010) Myxobacterial secondary metabolites:
Bioactivities and modes-of-action. Natural Product Reports 27,
1276-1295.
• Adhikary,T., Kaddatz,K., Finkernagel,F., Schonbauer,A., Meissner,W.,
Scharfe,M., Jarek,M., Blöcker,H., Muller-Brusselbach,S., & Müller,R.
(2011) Genomewide analyses defi ne different modes of transcriptional
regulation by peroxisome proliferator-activated receptor-beta/
delta (PPARbeta/delta). PLoS ONE 6, e16344.
• Capell,A., Liebscher,S., Fellerer,K., Brouwers,N., Willem,M.,
Lammich,S., Gijselinck,I., Bittner,T., Carlson,A.M., Sasse,F., Kunze,B.,
Steinmetz,H., Jansen,R., Dormann,D., Sleegers,K., Cruts,M., Herms,J.,
Van,B.C., & Haass,C. (2011) Rescue of progranulin defi ciency associated
with frontotemporal lobar degeneration by alkalizing reagents
and inhibition of vacuolar ATPase. Journal of Neuroscience 31, 1885-
1894.