Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

WISSENSCHAFTLICHER ERGEBNISBERICHT | TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH
• 19. Teng MW, Ngiow SF, von Scheidt B, McLaughlin N, Sparwasser T
& Smyth MJ (2010) Conditional regulatory T-cell depletion releases
adaptive immunity preventing carcinogenesis and suppressing
established tumor growth. Cancer Research 70(20), 7800-7809.
• 20. Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow
SF, Smyth MJ, Hamann A, Huehn J & Sparwasser T (2010) Selective
depletion of Foxp3+ regulatory T cells improves effective therapeutic
vaccination against established melanoma. Cancer Research 70(20),
7788-7799.
• 21. Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ,
Langa F, Di Santo JP & Eberl G (2010) Lineage relationship analysis
of ROR t+ innate lymphoid cells. Science 330(6004), 665-669.
• 22. Navarro S, Cossalter G, Chiavaroli C, Kanda A, Fleury S, Lazzari
A, Cazareth J, Sparwasser T, Dombrowicz D, Glaichenhaus N &
Julia V (2010) The oral administration of bacterial extracts prevents
asthma via the recruitment of regulatory T cells to the airways.
Mucosal Immunology 4(1), 53-65 (Epub 01 Sept. 2010).
• 23. Arnold I, Lee J, Amieva M, Roers A, Flavell R, Sparwasser T
& Müller A (2010) Tolerance rather than immunity protects from
Helicobacter pylori-induced gastric preneoplasia. Gastroenterology
140(1), 199-209 (Epub 22 June 2010).
• 24. Baru AM. Hartl A, Lahl K, Krishnaswamy JK, Fehrenbach H,
Yildirim A, Garn H, Renz H, Behrens G & Sparwasser T (2010)
Selective depletion of Foxp3+ regulatory T cells during sensitization
phase aggravates experimental allergic airway infl ammation.
European Journal of Immunology 40(8), 2259-2266.
• 25. Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer
M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel
B, Gewies A, Peschel C & Ruland J (2010) The fusion kinase ITK-
SYK mimics a T-cell receptor signal and drives oncogenesis in
conditional mouse models of peripheral T cell lymphoma. Journal of
Experimental Medicine 207(5), 1031-1044.
• 26. Suttner K, Depner M, Wetzke M, Klopp N, von Mutius E, Illig
T, Sparwasser T & Kabesch M (2010) Genetic variants harbored in
the forkhead box protein 3 locus increase hay fever risk. Journal of
Allergy and Clinical Immunology 125(6), 1395-1399.
• 27. Boissonnas A, Scholer-Dahirel A, Simon-Blancal V, Pace L, Valet
F, Kissenpfennig A, Sparwasser T, Malissen B, Fetler L & Amigorenga
S (2010) FoxP3+ T cells induce perforin-dependent dendritic cell
death in tumor-draining lymph nodes. Immunity 32(2), 266-278.
• 28. Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H,
Sparwasser T*, Probst HC* & van den Broek M* (2010) FoxP3+
regulatory T cells essentially contribute to peripheral CD8+ T cell
tolerance induced by steady state dendritic cells. Proceedings of
the National Academy of Sciences U S A 107(1), 199-203 *(equally
contributed) (Epub 2009).
• 29. Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl
K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G,
Rothenfusser S, Bourquin C & Endres S (2010) Immunostimulatory
RNA blocks suppression by regulatory T cells. Journal of Immunology
184(2), 939-946 (Epub 2009).
Forschungsgruppe um Prof. Häußler
• 1. Schmidt, J, Müsken M, Becker T, Magnowska Z, Bertinetti D,
Möller S, Zimmermann B, Herberg FW, Jänsch L & Häussler S (2011).
The Pseudomonas aeruginosa chemotaxis methyltransferase CheR1
impacts on bacterial surface sampling. PLoS One (in press).
• 2. Häussler S (2010) Multicellular signalling and growth of
Pseudomonas aeruginosa. International Journal of Medical
Microbiology 300(8), 544-548.
• 3. Pommerenke C, Müsken M, Becker T, Dotsch A, Klawonn F
& Häussler S (2010) Global genotype-phenotype correlations in
Pseudomonas aeruginosa. PLoS Pathogens 6(8). pii: e1001074.
147
• 4. Müsken M, Di Fiore S, Römling U & Häussler S (2010) A 96-wellplate-based
optical method for the quantitative and qualitative
evaluation of Pseudomonas aeruginosa biofi lm formation and its
application to susceptibility testing. Nature Protocols 5(8), 1460-1469.
• 5. Häussler S & Parsek MR (2010) Biofi lms 2009: new perspectives
at the heart of surface-associated microbial communities. Journal of
Bacteriology 192(12), 2941-2949.
• 6. Dötsch A, Klawonn F, Jarek M, Scharfe M, Blocker H & Häussler S
(2010) Evolutionary conservation of essential and highly expressed
genes in Pseudomonas aeruginosa. BMC Genomics 11, 234.
• 7. Müsken M, Di Fiore S, Dotsch A, Fischer R & Häussler S
(2010) Genetic determinants of Pseudomonas aeruginosa biofi lm
establishment. Microbiology 156(Pt 2), 431-441.
Forschungsgruppe um Prof. Ott
• 1. Sharma AD, Narain N, Händel EM, Iken M, Singhal N, Cathomen
T, Manns M, Schöler HR, Ott M & Cantz T (2011) MicroRNA-221
regulates FAS-induced fulminant liver failure. Hepatology [Epub
ahead of print].
• 2. Sharma AD, Razvan I, Bock M, Cantz T, Manns MP & Ott M (2011)
Liver (chapter 33); G. Steinhoff (ed.) Regenerative Medicine: From
protocol to patient, pp. 773-803.
• 3. Razvan I, Rüdrich U, Rothe M, Kirsch S, Maasoumy B, Narain
N, Verfaillied CM, Sancho-Bru P, Iken M, Popescu I, Schambach
A, Manns MP & Bock M (2011) Induction of a mature hepatocyte
phenotype in adult liver derived progenitor cells by ectopic
expression of transcription factors. Stem Cell Research Feb 24 [Epub
ahead of print].
• 4. Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington
ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K,
Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA & Spits H (2010)
Generation of human antigen-specifi c monoclonal IgM antibodies
using vaccinated “human immune system” mice. PLoS One 5(10).
• 5. Sancho-Bru P, Roelandt P, Narain N, Pauwelyn K, Notelaers T,
Shimizu T, Ott M & Verfaillie C (2010) Directed differentiation of
murine-induced pluripotent stem cells to functional hepatocyte-like
cells. Journal of Hepatology 54(1), 98-107.
• 6. Asgari S, Pournasr B, Salekdeh GH, Ghodsizadeh A, Ott M &
Baharvand H (2010) Induced pluripotent stem cells: a new era for
hepatology. Journal of Hepatology 53(4), 738-751.
• 7. Bitzegeio J, Bankwitz D, Hueging K, Haid S, Brohm C, Zeisel MB,
Herrmann E, Iken M, Ott M, Baumert TF & Pietschmann T (2010)
Adaptation of hepatitis C virus to mouse CD81 permits infection of
mouse cells in the absence of human entry factors. PLoS Pathogens
6, e1000978.
• 8. Ciesek S, Steinmann E, Iken M, Ott M, Helfritz FA,
Wappler I, Manns MP, Wedemeyer H & Pietschmann T (2010)
Glucocorticosteroids increase cell entry by hepatitis C virus.
Gastroenterology 138(5), 1875-1884.
• 9. Hettwer M, Reis-Fernandes MA, Iken M, Ott M, Steinberg P &
Nau H (2010) Metabolic activation capacity by primary hepatocytes
expands the applicability of the embryonic stem cell test as
alternative to experimental animal testing. Reproductive Toxicology
30(1), 113-120.
• 10. Stange MA, Tutarel O, Pischke S, Schneider A, Strassburg CP,
Becker T, Barg-Hock H, Basturk M, Wursthorn K, Cornberg M, Ott
M, Greten TF, Manns MP & Wedemeyer H (2010) Fulminant hepatic
failure due to chemotherapy-induced hepatitis B reactivation: role of
rituximab. Zeitschrift für Gastroenterologie 48(2), 258-263.