01.12.2012 Aufrufe

Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

Ergebnisbericht 2010/11 - Helmholtz-Zentrum für Infektionsforschung

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• Victora,G.D., Schwickert,T.A., Fooksman,D.R., Kamphorst,A.O.,<br />

Meyer-Hermann,M., Dustin,M.L., & Nussenzweig,M.C. (<strong>2010</strong>) Germinal<br />

center dynamics revealed by multiphoton microscopy with a<br />

photoactivatable fl uorescent reporter. Cell 143, 592-605.<br />

• Grise,G. & Meyer-Hermann,M. (20<strong>11</strong>) Surface reconstruction using<br />

Delaunay triangulation for applications in life sciences. Computer<br />

Physics Communications 182, 967-977.<br />

• Kobayashi,Y. & Telschow,A. (20<strong>11</strong>) The concept of effective recombination<br />

rate and its application in speciation theory. Evolution 65,<br />

617-628.<br />

Abt. <strong>für</strong> Chemische Biologie | Dr. Ronald Frank, Dr. Florenz Sasse<br />

• Andreetto,E., Yan,L.M., Tatarek-Nossol,M., Velkova,A., Frank,R., &<br />

Kapurniotu,A. (<strong>2010</strong>) Identifi cation of hot regions of the abeta-IAPP<br />

interaction interface as high-affi nity binding sites in both cross- and<br />

self-association. Angewandte Chemie International Edition 49, 3081-<br />

• Barnickel,B., Bayliffe,F., Diestel,R., Kempf,K., Laschat,S., Pachali,S.,<br />

Sasse,F., Schlenk,A., & Schobert,R. (<strong>2010</strong>) Structure-activity relationships<br />

of precursors and analogs of natural 3-enoyl-tetramic acids.<br />

Chemistry & Biodiversity 7, 2830-2845.<br />

• Beutling,U. & Frank,R. (<strong>2010</strong>) Epitope analysis using synthetic peptide<br />

repertoires prepared by SPOT synthesis technology. In: Antibody<br />

Engineering (Kontermann,R. & Dübel,S., eds.), Springer-Verlag,<br />

Berlin, Heidelberg.<br />

• Bourbeillon,J., Orchard,S., Benhar,I., Borrebaeck,C., de,D.A.,<br />

Dubel,S., Frank,R., Gibson,F., Gloriam,D., Haslam,N., Hiltker,T.,<br />

Humphrey-Smith,I., Hust,M., Juncker,D., Koegl,M., Konthur,Z.,<br />

Korn,B., Krobitsch,S., Muyldermans,S., Nygren,P.A., Palcy,S., Polic,B.,<br />

Rodriguez,H., Sawyer,A., Schlapshy,M., Snyder,M., Stoevesandt,O.,<br />

Taussig,M.J., Templin,M., Uhlen,M., van der,M.S., Wingren,C.,<br />

Hermjakob,H., & Sherman,D. (<strong>2010</strong>) Minimum information about a<br />

protein affi nity reagent (MIAPAR). Nature Biotechnology 28, 650-653.<br />

• Brodmann,T., Janssen,D., Sasse,F., Irschik,H., Jansen,R., Müller,R., &<br />

Kalesse,M. (<strong>2010</strong>) Isolation and synthesis of chivotriene, a chivosazole<br />

shunt product from Sorangium cellulosum. European Journal of<br />

Organic Chemistry 27, 5155-5159.<br />

• Buchner,A., Pohla,H., Willimsky,G., Frankenberger,B., Frank,R., Baur-<br />

Melnyk,A., Siebels,M., Stief,C.G., Hofstetter,A., Kopp,J., Pezzutto,A.,<br />

Blankenstein,T., Oberneder,R., & Schendel,D.J. (<strong>2010</strong>) Phase 1 trial of<br />

allogeneic gene-modifi ed tumor cell vaccine RCC-26/CD80/IL-2 in<br />

patients with metastatic renal cell carcinoma. Human Gene Therapy<br />

21, 285-297.<br />

• Bulow,L., Nickeleit,I., Girbig,A.K., Brodmann,T., Rentsch,A.,<br />

Eggert,U., Sasse,F., Steinmetz,H., Frank,R., Carlomagno,T.,<br />

Malek,N.P., & Kalesse,M. (<strong>2010</strong>) Synthesis and biological characterization<br />

of argyrin F. ChemMedChem 5, 832-836.<br />

• Frank,R., Theis,F.J., & Klamt,S. (<strong>2010</strong>) From binary to multivalued to<br />

continuous models: the lac operon as a case study. Journal of Integrative<br />

Bioinformatics 7, 151-169.<br />

• Gloriam,D.E., Orchard,S., Bertinetti,D., Bjorling,E., Bongcam-<br />

Rudloff,E., Borrebaeck,C.A., Bourbeillon,J., Bradbury,A.R., de,D.A.,<br />

Dubel,S., Frank,R., Gibson,T.J., Gold,L., Haslam,N., Herberg,F.W.,<br />

Hiltke,T., Hoheisel,J.D., Kerrien,S., Koegl,M., Konthur,Z., Korn,B.,<br />

Landegren,U., Montecchi-Palazzi,L., Palcy,S., Rodriguez,H.,<br />

Schweinsberg,S., Sievert,V., Stoevesandt,O., Taussig,M.J., Ueffi ng,M.,<br />

Uhlen,M., van der,M.S., Wingren,C., Woollard,P., Sherman,D.J., &<br />

Hermjakob,H. (<strong>2010</strong>) A community standard format for the representation<br />

of protein affi nity reagents. Molecular and Cellular Proteomics<br />

9, 1-10.<br />

• Harmrolfs,K., Brunjes,M., Drager,G., Floss,H.G., Sasse,F., Taft,F., &<br />

Kirschning,A. (<strong>2010</strong>) Cyclization of synthetic seco-proansamitocins<br />

to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.<br />

ChemBioChem <strong>11</strong>, 2517-2520.<br />

WISSENSCHAFTLICHER ERGEBNISBERICHT | Veröffentlichungen<br />

163<br />

• Heinzelmann,K., Scholz,B.A., Nowak,A., Fossum,E., Kremmer,E.,<br />

Haas,J., Frank,R., & Kempkes,B. (<strong>2010</strong>) Kaposi’s sarcoma-associated<br />

herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a<br />

novel interaction partner of CSL/CBF1, the major downstream effector<br />

of Notch signaling. Journal of Virology 84, 12255-12264.<br />

• Kubicek,K., Grimm,S.K., Orts,J., Sasse,F., & Carlomagno,T. (<strong>2010</strong>)<br />

The tubulin-bound structure of the antimitotic drug tubulysin. Angewandte<br />

Chemie International Edition 49, 4809-4812.<br />

• Meens,J., Bolotin,V., Frank,R., Bohmer,J., & Gerlach,G.F. (<strong>2010</strong>) Characterization<br />

of a highly immunogenic Mycoplasma hyopneumoniae<br />

lipoprotein Mhp366 identifi ed by peptide-spot array. Veterinary<br />

Microbiology 142, 293-302.<br />

• Meyer,T., Stratmann-Selke,J., Meens,J., Schirrmann,T., Gerlach,G.F.,<br />

Frank,R., Dubel,S., Strutzberg-Minder,K., & Hust,M. (<strong>2010</strong>) Isolation<br />

of scFv fragments specifi c to OmpD of Salmonella typhimurium.<br />

Veterinary Microbiology 147, 162-169.<br />

• Micklinghoff,J.C., Schmidt,M., Geffers,R., Tegge,W., & Bange,F.C.<br />

(<strong>2010</strong>) Analysis of expression and regulatory functions of the<br />

ribosome-binding protein TypA in Mycobacterium tuberculosis under<br />

stress conditions. Archives of Microbiology 192, 499-504.<br />

• Nickl,C.K., Raidas,S.K., Zhao,H., Sausbier,M., Ruth,P., Tegge,W.,<br />

Brayden,J.E., & Dostmann,W.R. (<strong>2010</strong>) (d)-Amino acid analogues of<br />

DT-2 as highly selective and superior inhibitors of cGMP-dependent<br />

protein kinase Ialpha. Biochimica et Biophysica Acta 1804, 524-532.<br />

• Nicolas,L., Anderl,T., Sasse,F., Steinmetz,H., Jansen,R., Hofl e,G.,<br />

Laschat,S., & Taylor,R.E. (<strong>2010</strong>) Gephyronic acid, a missing link<br />

between polyketide inhibitors of eukaryotic protein synthesis (Part I):<br />

Structural revision and stereochemical assignment of gephyronic<br />

acid. Angewandte Chemie International Edition 50, 938-941.<br />

• Rink,C., Sasse,F., Zubriene,A., Matulis,D., & Maier,M.E. (<strong>2010</strong>) Probing<br />

the infl uence of an allylic methyl group in zearalenone analogues<br />

on binding to Hsp90. Chemistry 16, 14469-14478.<br />

• Schackel,R., Hinkelmann,B., Sasse,F., & Kalesse,M. (<strong>2010</strong>) The synthesis<br />

of novel disorazoles. Angewandte Chemie International Edition<br />

49, 1619-1622.<br />

• Schlenk,A., Diestel,R., Sasse,F., & Schobert,R. (<strong>2010</strong>) A selective<br />

3-acylation of tetramic acids and the fi rst synthesis of ravenic acid.<br />

Chemistry 16, 2599-2604.<br />

• Schobert,R., Sasse,F., Biersack,B., Effenberger,K., Breyer,S., &<br />

Diestel,R. (<strong>2010</strong>) Tumor-selective amphiphilic para-quinones and<br />

tetramic acids. International Journal of Clinical Pharmacology and<br />

Therapeutics 48, 459-461.<br />

• Schulz,S., Dickschat,J.S., Kunze,B., Wagner-Döbler,I., Diestel,R., &<br />

Sasse,F. (<strong>2010</strong>) Biological activity of volatiles from marine and terrestrial<br />

bacteria. Marine Drugs 8, 2976-2987.<br />

• Sharma,R.K., Sundriyal,S., Wangoo,N., Tegge,W., & Jain,R. (<strong>2010</strong>)<br />

New antimicrobial hexapeptides: synthesis, antimicrobial activities,<br />

cytotoxicity, and mechanistic studies. ChemMedChem 5, 86-95.<br />

• Voigt,J., Kiess,M., Getzlaff,R., Wostemeyer,J., & Frank,R. (<strong>2010</strong>) Generation<br />

of the heterodimeric precursor GP3 of the Chlamydomonas<br />

cell wall. Molecular Microbiology 77, 1512-1526.<br />

• Capell,A., Liebscher,S., Fellerer,K., Brouwers,N., Willem,M.,<br />

Lammich,S., Gijselinck,I., Bittner,T., Carlson,A.M., Sasse,F., Kunze,B.,<br />

Steinmetz,H., Jansen,R., Dormann,D., Sleegers,K., Cruts,M., Herms,J.,<br />

Van,B.C., & Haass,C. (20<strong>11</strong>) Rescue of progranulin defi ciency associated<br />

with frontotemporal lobar degeneration by alkalizing reagents<br />

and inhibition of vacuolar ATPase. Journal of Neuroscience 31, 1885-<br />

1894.<br />

• Elsebai,M.F., Kehraus,S., Lindequist,U., Sasse,F., Shaaban,S.,<br />

Gutschow,M., Josten,M., Sahl,H.G., & Konig,G.M. (20<strong>11</strong>) Antimicrobial<br />

phenalenone derivatives from the marine-derived fungus Coniothyrium<br />

cereale. Organic and Biomolecular Chemistry 9, 802-808.

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