Artemisinin-based combination therapy for ... - The Cochrane Library

9.4 Gametocyte carriage day
21
2 1123 Risk Ratio (M-H, Random, 95% CI) 7.23 [0.10, 519.79]
9.5 Gametocyte carriage day
28
2 1124 Risk Ratio (M-H, Random, 95% CI) 9.68 [1.23, 75.98]
10 Serious adverse events
(including deaths)
7 2374 Risk Ratio (M-H, Fixed, 95% CI) 0.90 [0.38, 2.15]
11 Early vomiting 7 2473 Risk Ratio (M-H, Fixed, 95% CI) 0.90 [0.69, 1.16]
12 Sensitivity analysis: Total
Failure Day 63 PCR unadjusted
4 Risk Ratio (M-H, Random, 95% CI) Subtotals only
12.1 Total Failure (P.
falciparum) Day 63 PCR
unadjusted
4 1627 Risk Ratio (M-H, Random, 95% CI) 0.94 [0.52, 1.70]
12.2 Total Failure Day 63
PCR unadjusted (losses to
follow up included as failures)
4 1801 Risk Ratio (M-H, Random, 95% CI) 0.95 [0.65, 1.38]
12.3 Total Failure Day 63
PCR unadjusted (losses to
follow up included as successes)
4 1801 Risk Ratio (M-H, Random, 95% CI) 0.94 [0.52, 1.68]
13 Sensitivity analysis: Total
Failure Day 63 PCR adjusted
4 Risk Ratio (M-H, Random, 95% CI) Subtotals only
13.1 Total Failure (P.
falciparum) Day 63 PCR
adjusted
4 1497 Risk Ratio (M-H, Random, 95% CI) 0.57 [0.17, 1.83]
13.2 Total Failure Day 63
PCR adjusted (indeterminate
PCR included as failures)
4 1508 Risk Ratio (M-H, Random, 95% CI) 0.67 [0.32, 1.39]
13.3 Total Failure Day 63
PCR adjusted (new infections
included as successes)
4 1627 Risk Ratio (M-H, Random, 95% CI) 0.67 [0.34, 1.35]
13.4 Total Failure Day 63
PCR adjusted (losses to follow
up included as failures)
4 1801 Risk Ratio (M-H, Random, 95% CI) 0.93 [0.67, 1.30]
13.5 Total Failure Day 63
PCR adjusted (losses to follow
up included as successes)
4 1801 Risk Ratio (M-H, Random, 95% CI) 0.67 [0.34, 1.33]
Comparison 2. Dihydroartemisinin-piperaquine vs Artemether-lumefantrine
Outcome or subgroup title
No. of
studies
No. of
participants Statistical method Effect size
1 Total Failure (P. falciparum) Day
42 PCR unadjusted
5 Risk Ratio (M-H, Random, 95% CI) Subtotals only
1.1 Africa 3 1136 Risk Ratio (M-H, Random, 95% CI) 0.44 [0.20, 0.95]
1.2 Asia 1 356 Risk Ratio (M-H, Random, 95% CI) 0.60 [0.35, 1.05]
1.3 Oceania 1 216 Risk Ratio (M-H, Random, 95% CI) 1.07 [0.76, 1.50]
2 Total Failure (P. falciparum) Day
42 PCR adjusted
5 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
2.1 Africa 3 869 Risk Ratio (M-H, Fixed, 95% CI) 0.39 [0.24, 0.64]
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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