Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 9.6. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 6<br />
Proportion anaemic (Haemoglobin < 11 g/dl).<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 9 Artemether-lumefantrine vs Artesunate plus amodiaquine<br />
Outcome: 6 Proportion anaemic (Haemoglobin < 11 g/dl)<br />
Study or subgroup AL6 AS+AQ Risk Ratio Risk Ratio<br />
1 At baseline<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Guthmann 2004 AGO 33/61 34/64 1.02 [ 0.73, 1.41 ]<br />
2 At day 28<br />
Guthmann 2004 AGO 8/60 10/63 0.84 [ 0.36, 1.98 ]<br />
0.01 0.1 1 10 100<br />
Favours AL6 Favours AS+AQ<br />
Analysis 9.7. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 7 Serious<br />
adverse events (including deaths).<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 9 Artemether-lumefantrine vs Artesunate plus amodiaquine<br />
Outcome: 7 Serious adverse events (including deaths)<br />
Study or subgroup AL6 AS+AQ Risk Ratio Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/149 0/360 0.0 [ 0.0, 0.0 ]<br />
Mutabingwa 2004 TZA 1/519 0/515 2.98 [ 0.12, 72.91 ]<br />
Falade 2005 NGA 0/66 0/66 0.0 [ 0.0, 0.0 ]<br />
Bukirwa 2005 UGA 1/202 1/201 1.00 [ 0.06, 15.80 ]<br />
Dorsey 2006 UGA 14/202 15/232 1.07 [ 0.53, 2.17 ]<br />
Kobbe 2007 GHA 2/120 2/117 0.98 [ 0.14, 6.81 ]<br />
Total (95% CI) 1258 1491 1.11 [ 0.59, 2.08 ]<br />
Total events: 18 (AL6), 18 (AS+AQ)<br />
Heterogeneity: Chi 2 = 0.40, df = 3 (P = 0.94); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 0.33 (P = 0.74)<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.01 0.1 1 10 100<br />
Favours AL6 Favours AS+AQ<br />
170