Artemisinin-based combination therapy for ... - The Cochrane Library

Analysis 10.3. Comparison 10 Artemether-lumefantrine vs Artesunate plus sulfadoxine-pyrimethamine,
Outcome 3 Total Failure (P. falciparum) Day 28 PCR unadjusted.
Review: Artemisinin-based combination therapy for treating uncomplicated malaria
Comparison: 10 Artemether-lumefantrine vs Artesunate plus sulfadoxine-pyrimethamine
Outcome: 3 Total Failure (P. falciparum) Day 28 PCR unadjusted
1 Africa
Study or subgroup AL6 AS+SP Risk Ratio Weight Risk Ratio
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI
Mukhtar 2005 SDN 8/80 12/77 32.8 % 0.64 [ 0.28, 1.48 ]
Subtotal (95% CI) 80 77 32.8 % 0.64 [ 0.28, 1.48 ]
Total events: 8 (AL6), 12 (AS+SP)
Heterogeneity: not applicable
Test for overall effect: Z = 1.04 (P = 0.30)
2 Oceania
Karunajeewa 2007 PNG 20/113 25/112 67.2 % 0.79 [ 0.47, 1.34 ]
Subtotal (95% CI) 113 112 67.2 % 0.79 [ 0.47, 1.34 ]
Total events: 20 (AL6), 25 (AS+SP)
Heterogeneity: not applicable
Test for overall effect: Z = 0.86 (P = 0.39)
Total (95% CI) 193 189 100.0 % 0.74 [ 0.48, 1.16 ]
Total events: 28 (AL6), 37 (AS+SP)
Heterogeneity: Chi 2 = 0.18, df = 1 (P = 0.67); I 2 =0.0%
Test for overall effect: Z = 1.30 (P = 0.19)
0.01 0.1 1 10 100
Favours AL Favours AS+SP
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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