Artemisinin-based combination therapy for ... - The Cochrane Library

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(... Continued) Study or subgroup ASMQ Control Risk Ratio Risk Ratio n/N n/N M-H,Random,95% CI M-H,Random,95% CI Mayxay 2003 LAO 0/106 3/96 0.13 [ 0.01, 2.48 ] Subtotal (95% CI) 468 436 0.38 [ 0.05, 2.84 ] Total events: 9 (ASMQ), 12 (Control) Heterogeneity: Tau 2 = 2.64; Chi 2 = 8.30, df = 3 (P = 0.04); I 2 =64% Test for overall effect: Z = 0.95 (P = 0.34) 3 Day 28: AS+MQ vs Artesunate plus amodiaquine Faye 2003 SEN 0/142 0/340 0.0 [ 0.0, 0.0 ] Subtotal (95% CI) 142 340 0.0 [ 0.0, 0.0 ] Total events: 0 (ASMQ), 0 (Control) Heterogeneity: not applicable Test for overall effect: Z = 0.0 (P < 0.00001) 4 Day 28: AS+MQ vs Artesunate plus sulfadoxine-pyrimethamine Subtotal (95% CI) 0 0 0.0 [ 0.0, 0.0 ] Total events: 0 (ASMQ), 0 (Control) Heterogeneity: not applicable Test for overall effect: not applicable 5 Day 28: AS+MQ vs Amodiaquine plus sulfadoxine-pyrimethamine Faye 2003 SEN 0/142 0/154 0.0 [ 0.0, 0.0 ] Subtotal (95% CI) 142 154 0.0 [ 0.0, 0.0 ] Total events: 0 (ASMQ), 0 (Control) Heterogeneity: not applicable Test for overall effect: Z = 0.0 (P < 0.00001) Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 0.005 0.1 1 10 200 Favours ASMQ Favours Control 212
Analysis 20.1. Comparison 20 How does Artemether-lumefantrine perform?, Outcome 1 Effectiveness: Total Failure (P. falciparum) Day PCR adjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 20 How does Artemether-lumefantrine perform? Outcome: 1 Effectiveness: Total Failure (P. falciparum) Day PCR adjusted Study or subgroup AL Control Risk Ratio Risk Ratio 1 Day 42: AL vs Dihydroartemisinin-piperaquine n/N n/N M-H,Random,95% CI M-H,Random,95% CI Ratcliff 2005 IDN 3/138 3/179 1.30 [ 0.27, 6.33 ] Kamya 2006 UGA 28/117 13/130 2.39 [ 1.30, 4.40 ] Yeka 2007 UGA 10/141 4/190 3.37 [ 1.08, 10.52 ] Karunajeewa 2007 PNG 5/74 12/77 0.43 [ 0.16, 1.17 ] Zongo 2007 BFA 7/128 4/163 2.23 [ 0.67, 7.45 ] Subtotal (95% CI) 598 739 1.61 [ 0.77, 3.39 ] Total events: 53 (AL), 36 (Control) Heterogeneity: Tau 2 = 0.42; Chi 2 = 10.17, df = 4 (P = 0.04); I 2 =61% Test for overall effect: Z = 1.26 (P = 0.21) 2 Day 42: AL vs Artesunate plus mefloquine Hutagalung 2002 THA 3/201 9/212 0.35 [ 0.10, 1.28 ] Mayxay 2003 LAO 3/96 0/106 7.72 [ 0.40, 147.59 ] Van den Broek 2003a BGD 3/102 0/105 7.20 [ 0.38, 137.74 ] Stohrer 2003 LAO 3/37 0/45 8.47 [ 0.45, 158.99 ] Subtotal (95% CI) 436 468 2.66 [ 0.35, 20.09 ] Total events: 12 (AL), 9 (Control) Heterogeneity: Tau 2 = 2.64; Chi 2 = 8.30, df = 3 (P = 0.04); I 2 =64% Test for overall effect: Z = 0.95 (P = 0.34) 3 Day 28: AL vs Artesunate plus amodiaquine Faye 2003 SEN 0/147 0/340 0.0 [ 0.0, 0.0 ] Guthmann 2004 AGO 0/59 0/60 0.0 [ 0.0, 0.0 ] Falade 2005 NGA 0/59 0/56 0.0 [ 0.0, 0.0 ] Bukirwa 2005 UGA 2/102 0/68 3.35 [ 0.16, 68.71 ] Dorsey 2006 UGA 0/95 2/100 0.21 [ 0.01, 4.33 ] Adjei 2006 GHA 4/101 2/104 2.06 [ 0.39, 11.00 ] Owusu-Agyei 2006 GHA 12/122 7/136 1.91 [ 0.78, 4.70 ] Kobbe 2007 GHA 12/92 7/88 1.64 [ 0.68, 3.97 ] Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 0.002 0.1 1 10 500 Favours AL Favours Control (Continued ...) 213
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Artemisinin-based combination thera
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Analysis 2.2. Comparison 2 Dihydroa
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Analysis 10.5. Comparison 10 Arteme
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[Intervention Review] Artemisinin-b
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B A C K G R O U N D Malaria is a di
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drugs and the treatment comparisons
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this analysis into participants who
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Figure 1. Methodological quality su
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confidence intervals of the estimat
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Anaemia Hasugian 2005 IDN found tha
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Three trials report significantly m
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or those treated for P. vivax at ba
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Early vomiting Not reported. D I S
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Figure 4. Olliaro-Vaillant plot. Da
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Figure 10. Olliaro-Vaillant plot. D
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of findings tables’. For these ta
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Huambo and Bie provinces, central A
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References to studies excluded from
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Adjuik 2004 Adjuik M, Babiker A, Ga
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C H A R A C T E R I S T I C S O F S
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Ashley 2003a THA (Continued) Outcom
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Ashley 2003b THA (Continued) Alloca
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Ashley 2005 THA (Continued) Exclusi
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Bonnet 2004 GIN (Continued) Item Au
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Bukirwa 2005 UGA Methods Trial desi
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Djimde 2004 MLI (Continued) • AS
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Dorsey 2006 UGA (Continued) Item Au
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Fanello 2004 RWA Methods Trial desi
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Faye 2003 SEN (Continued) Outcomes
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Grande 2005 PER (Continued) Allocat
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Guthmann 2004 AGO (Continued) All d
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Hasugian 2005 IDN Methods Trial des
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Hutagalung 2002 THA (Continued) 5.
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Janssens 2003 KHM (Continued) Free
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Karunajeewa 2007 PNG (Continued) Ri
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Kobbe 2007 GHA (Continued) Exclusio
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Martensson 2003 TZA Methods Trial d
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Mayxay 2003 LAO (Continued) 1. Feve
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Menard 2006 MDG Methods Trial desig
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Mens 2007 KEN (Continued) Risk of b
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Mutabingwa 2004 TZA (Continued) •
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Owusu-Agyei 2006 GHA (Continued) Fr
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Sagara 2005b MLI (Continued) • 25
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Smithuis 2004 MMR (Continued) Risk
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Stohrer 2003 LAO Methods Trial desi
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Swarthout 2004 ZAR (Continued) Note
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Tran 2002 VNM Methods Trial design:
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Van den Broek 2003a BGD (Continued)
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Van Vugt 1998 THA Methods Trial des
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Yeka 2004 UGA (Continued) Risk of b
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Yeka 2007 UGA (Continued) Free of o
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Zongo 2007 BFA (Continued) Novartis
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(Continued) Fofana 2005 Conference
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D A T A A N D A N A L Y S E S Compa
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2.2 Asia 1 317 Risk Ratio (M-H, Fix
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Comparison 5. Dihydroartemisinin-pi
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Comparison 8. Artesunate plus meflo
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Comparison 10. Artemether-lumefantr
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Comparison 12. Artesunate plus amod
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5.2 DHA-P 3 doses 3 1116 Risk Ratio
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Comparison 21. How does Artesunate
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(... Continued) Study or subgroup D
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Analysis 1.12. Comparison 1 Dihydro
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Analysis 6.6. Comparison 6 Artesuna
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1 Dorsey 2006 UGA; Faye 2003 SEN; K
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