Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 13.3. Comparison 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxinepyrimethamine,<br />
Outcome 3 Gametocyte development.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 3 Gametocyte development<br />
Study or subgroup AS+AQ AQ+SP Risk Ratio Weight Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Staedke 2003 UGA 6/121 9/125 5.3 % 0.69 [ 0.25, 1.88 ]<br />
Yeka 2004 UGA 104/551 158/557 94.7 % 0.67 [ 0.54, 0.83 ]<br />
Total (95% CI) 672 682 100.0 % 0.67 [ 0.54, 0.82 ]<br />
Total events: 110 (AS+AQ), 167 (AQ+SP)<br />
Heterogeneity: Chi 2 = 0.00, df = 1 (P = 0.95); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 3.73 (P = 0.00019)<br />
0.2 0.5 1 2 5<br />
Favours ASAQ Favours AQSP<br />
Analysis 13.4. Comparison 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxinepyrimethamine,<br />
Outcome 4 Gametocyte carriage.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 4 Gametocyte carriage<br />
Study or subgroup AS+AQ AQ+SP Risk Ratio Risk Ratio<br />
1 Gametocyte carriage day 0<br />
n/N n/N M-H,Random,95% CI M-H,Random,95% CI<br />
Faye 2003 SEN 0/360 5/161 0.04 [ 0.00, 0.73 ]<br />
Dorsey 2006 UGA 16/111 12/111 1.33 [ 0.66, 2.69 ]<br />
Menard 2006 MDG 3/83 2/83 1.50 [ 0.26, 8.75 ]<br />
Subtotal (95% CI) 554 355 0.69 [ 0.13, 3.59 ]<br />
Total events: 19 (AS+AQ), 19 (AQ+SP)<br />
Heterogeneity: Tau 2 = 1.36; Chi 2 = 5.97, df = 2 (P = 0.05); I 2 =66%<br />
Test <strong>for</strong> overall effect: Z = 0.44 (P = 0.66)<br />
2 Gametocyte carriage day 3<br />
Faye 2003 SEN 0/360 16/161 0.01 [ 0.00, 0.23 ]<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.001 0.01 0.1 1 10 100 1000<br />
Favours ASAQ Favours AQSP<br />
(Continued ...)<br />
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