Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Study or subgroup AL6 AQ+SP Risk Ratio Weight Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/147 2/156 9.7 % 0.21 [ 0.01, 4.38 ]<br />
Zongo 2005 BFA 37/245 11/233 45.2 % 3.20 [ 1.67, 6.12 ]<br />
Zongo 2007 BFA 36/178 11/171 45.0 % 3.14 [ 1.65, 5.97 ]<br />
Subtotal (95% CI) 570 560 100.0 % 2.88 [ 1.86, 4.47 ]<br />
Total events: 73 (AL6), 24 (AQ+SP)<br />
Heterogeneity: Chi 2 = 3.02, df = 2 (P = 0.22); I 2 =34%<br />
Test <strong>for</strong> overall effect: Z = 4.72 (P < 0.00001)<br />
0.01 0.1 1 10 100<br />
Favours AL6 Favours AQ+SP<br />
Analysis 11.2. Comparison 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine,<br />
Outcome 2 Total Failure (P. falciparum) Day 28 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 2 Total Failure (P. falciparum) Day 28 PCR adjusted<br />
Study or subgroup AL6 AQ+SP Risk Ratio Risk Ratio<br />
1 East Africa<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Fanello 2004 RWA 8/218 51/209 0.15 [ 0.07, 0.31 ]<br />
Dorsey 2006 UGA 0/95 16/96 0.03 [ 0.00, 0.50 ]<br />
Subtotal (95% CI) 313 305 0.12 [ 0.06, 0.24 ]<br />
Total events: 8 (AL6), 67 (AQ+SP)<br />
Heterogeneity: Chi 2 = 1.27, df = 1 (P = 0.26); I 2 =21%<br />
Test <strong>for</strong> overall effect: Z = 5.93 (P < 0.00001)<br />
2 West Africa<br />
Faye 2003 SEN 0/147 0/154 0.0 [ 0.0, 0.0 ]<br />
Zongo 2005 BFA 4/212 1/223 4.21 [ 0.47, 37.34 ]<br />
Zongo 2007 BFA 6/148 7/167 0.97 [ 0.33, 2.81 ]<br />
Subtotal (95% CI) 507 544 1.39 [ 0.55, 3.47 ]<br />
Total events: 10 (AL6), 8 (AQ+SP)<br />
Heterogeneity: Chi 2 = 1.43, df = 1 (P = 0.23); I 2 =30%<br />
Test <strong>for</strong> overall effect: Z = 0.70 (P = 0.49)<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.001 0.01 0.1 1 10 100 1000<br />
Favours AL6 Favours AQ+SP<br />
184