Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 15.4. Comparison 15 Dihydroartemisinin-piperaquine dose analysis (versus Artesunate plus<br />
mefloquine), Outcome 4 Total Failure Day 42 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 15 Dihydroartemisinin-piperaquine dose analysis (versus Artesunate plus mefloquine)<br />
Outcome: 4 Total Failure Day 42 PCR adjusted<br />
Study or subgroup DHA-P ASMQ Risk Ratio Weight Risk Ratio<br />
1 DHA-P 4 doses<br />
n/N n/N M-H,Random,95% CI M-H,Random,95% CI<br />
Ashley 2004 THA 1/146 7/145 18.9 % 0.14 [ 0.02, 1.14 ]<br />
Janssens 2003 KHM 3/189 2/200 22.9 % 1.59 [ 0.27, 9.39 ]<br />
Tran 2002 VNM 2/152 1/71 15.7 % 0.93 [ 0.09, 10.13 ]<br />
Subtotal (95% CI) 487 416 57.5 % 0.62 [ 0.14, 2.82 ]<br />
Total events: 6 (DHA-P), 10 (ASMQ)<br />
Heterogeneity: Tau 2 = 0.69; Chi 2 = 3.24, df = 2 (P = 0.20); I 2 =38%<br />
Test <strong>for</strong> overall effect: Z = 0.62 (P = 0.54)<br />
2 DHA-P 3 doses<br />
Ashley 2004 THA 1/158 7/145 18.9 % 0.13 [ 0.02, 1.05 ]<br />
Mayxay 2004 LAO 1/103 1/104 12.7 % 1.01 [ 0.06, 15.93 ]<br />
Smithuis 2004 MMR 2/315 0/315 10.9 % 5.00 [ 0.24, 103.73 ]<br />
Subtotal (95% CI) 576 564 42.5 % 0.70 [ 0.08, 5.87 ]<br />
Total events: 4 (DHA-P), 8 (ASMQ)<br />
Heterogeneity: Tau 2 = 1.80; Chi 2 = 4.05, df = 2 (P = 0.13); I 2 =51%<br />
Test <strong>for</strong> overall effect: Z = 0.33 (P = 0.74)<br />
Total (95% CI) 1063 980 100.0 % 0.62 [ 0.20, 1.91 ]<br />
Total events: 10 (DHA-P), 18 (ASMQ)<br />
Heterogeneity: Tau 2 = 0.62; Chi 2 = 7.30, df = 5 (P = 0.20); I 2 =32%<br />
Test <strong>for</strong> overall effect: Z = 0.84 (P = 0.40)<br />
0.002 0.1 1 10 500<br />
Favours DHA-P Favours ASMQ<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
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