Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 3.3. Comparison 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine, Outcome 3<br />
Total Failure (P. falciparum) Day 42 PCR unadjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine<br />
Outcome: 3 Total Failure (P. falciparum) Day 42 PCR unadjusted<br />
Study or subgroup DHA-P AS+AQ Risk Ratio Weight Risk Ratio<br />
1 Asia<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Hasugian 2005 IDN 5/86 14/66 100.0 % 0.27 [ 0.10, 0.72 ]<br />
Total (95% CI) 86 66 100.0 % 0.27 [ 0.10, 0.72 ]<br />
Total events: 5 (DHA-P), 14 (AS+AQ)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 2.62 (P = 0.0089)<br />
0.01 0.1 1 10 100<br />
Favours DHA-P Favours AS+AQ<br />
Analysis 3.4. Comparison 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine, Outcome 4<br />
Total Failure (P. falciparum) Day 42 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine<br />
Outcome: 4 Total Failure (P. falciparum) Day 42 PCR adjusted<br />
Study or subgroup DHA-P AS+AQ Risk Ratio Weight Risk Ratio<br />
1 Asia<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Hasugian 2005 IDN 1/82 7/59 100.0 % 0.10 [ 0.01, 0.81 ]<br />
Total (95% CI) 82 59 100.0 % 0.10 [ 0.01, 0.81 ]<br />
Total events: 1 (DHA-P), 7 (AS+AQ)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 2.16 (P = 0.031)<br />
0.01 0.1 1 10 100<br />
Favours DHA-P Favours AS+AQ<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
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