Artemisinin-based combination therapy for ... - The Cochrane Library

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(... Continued) Study or subgroup DHA-P AS+MQ Risk Ratio Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Grande 2005 PER 11/230 10/236 1.13 [ 0.49, 2.61 ] Subtotal (95% CI) 900 761 1.11 [ 0.91, 1.34 ] Total events: 191 (DHA-P), 137 (AS+MQ) Heterogeneity: Chi 2 = 1.99, df = 3 (P = 0.57); I 2 =0.0% Test for overall effect: Z = 1.00 (P = 0.32) 5 P. vivax parasitaemia by day 63 in those negative at baseline Ashley 2003b THA 48/143 36/133 1.24 [ 0.86, 1.78 ] Ashley 2004 THA 74/288 30/142 1.22 [ 0.84, 1.77 ] Grande 2005 PER 11/230 10/236 1.13 [ 0.49, 2.61 ] Subtotal (95% CI) 661 511 1.22 [ 0.95, 1.56 ] Total events: 133 (DHA-P), 76 (AS+MQ) Heterogeneity: Chi 2 = 0.04, df = 2 (P = 0.98); I 2 =0.0% Test for overall effect: Z = 1.54 (P = 0.12) 6 P. vivax parasitaemia by day 63 in those positive at baseline Ashley 2003b THA 4/13 6/19 0.97 [ 0.34, 2.78 ] Ashley 2004 THA 15/31 8/16 0.97 [ 0.53, 1.78 ] Subtotal (95% CI) 44 35 0.97 [ 0.57, 1.65 ] Total events: 19 (DHA-P), 14 (AS+MQ) Heterogeneity: Chi 2 = 0.00, df = 1 (P = 0.99); I 2 =0.0% Test for overall effect: Z = 0.11 (P = 0.91) Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 0.01 0.1 1 10 100 Favours DHA-P Favours AS+MQ 128
Analysis 1.8. Comparison 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine, Outcome 8 Gametocyte development (in those negative at baseline). Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine Outcome: 8 Gametocyte development (in those negative at baseline) Study or subgroup DHA-P AS+MQ Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Ashley 2003b THA 3/168 2/163 37.4 % 1.46 [ 0.25, 8.60 ] Ashley 2004 THA 9/310 1/153 24.6 % 4.44 [ 0.57, 34.74 ] Grande 2005 PER 8/227 2/213 38.0 % 3.75 [ 0.81, 17.48 ] Total (95% CI) 705 529 100.0 % 3.06 [ 1.13, 8.33 ] Total events: 20 (DHA-P), 5 (AS+MQ) Heterogeneity: Chi 2 = 0.87, df = 2 (P = 0.65); I 2 =0.0% Test for overall effect: Z = 2.19 (P = 0.028) 0.05 0.2 1 5 20 Favours DHA-P Favours AS+MQ Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 129
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Artemisinin-based combination thera
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Analysis 2.2. Comparison 2 Dihydroa
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Analysis 10.5. Comparison 10 Arteme
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[Intervention Review] Artemisinin-b
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B A C K G R O U N D Malaria is a di
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drugs and the treatment comparisons
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this analysis into participants who
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Figure 1. Methodological quality su
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confidence intervals of the estimat
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Anaemia Hasugian 2005 IDN found tha
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Three trials report significantly m
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or those treated for P. vivax at ba
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Early vomiting Not reported. D I S
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Figure 4. Olliaro-Vaillant plot. Da
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Figure 10. Olliaro-Vaillant plot. D
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of findings tables’. For these ta
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Huambo and Bie provinces, central A
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References to studies excluded from
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Adjuik 2004 Adjuik M, Babiker A, Ga
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C H A R A C T E R I S T I C S O F S
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Ashley 2003a THA (Continued) Outcom
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Ashley 2003b THA (Continued) Alloca
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Ashley 2005 THA (Continued) Exclusi
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Bonnet 2004 GIN (Continued) Item Au
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Bukirwa 2005 UGA Methods Trial desi
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Djimde 2004 MLI (Continued) • AS
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Dorsey 2006 UGA (Continued) Item Au
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Fanello 2004 RWA Methods Trial desi
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Faye 2003 SEN (Continued) Outcomes
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Grande 2005 PER (Continued) Allocat
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Guthmann 2004 AGO (Continued) All d
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Hasugian 2005 IDN Methods Trial des
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Hutagalung 2002 THA (Continued) 5.
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Janssens 2003 KHM (Continued) Free
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Karema 2004 RWA (Continued) Interve
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Karunajeewa 2007 PNG (Continued) Ri
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Kobbe 2007 GHA (Continued) Exclusio
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Koram 2003 GHA (Continued) Adequate
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Martensson 2003 TZA Methods Trial d
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(... Continued) Study or subgroup A
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(... Continued) Study or subgroup A
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Analysis 12.2. Comparison 12 Artesu
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Analysis 14.2. Comparison 14 Dihydr
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(... Continued) Study or subgroup D
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Analysis 20.1. Comparison 20 How do
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Analysis 21.1. Comparison 21 How do
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(Continued) 2. How does artesunate
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(Continued) Sensitivity analysis 1
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(Continued) Smithuis 2004 MMR (652
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Dihydroartemisinin-piperaquine vs A
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(Continued) Mayxay 2003 LAO (220 pa
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Artesunate plus mefloquine vs Amodi
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(Continued) Faye 2003 SEN (509 part
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Artemether-lumefantrine vs Artesuna
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(Continued) Zongo 2005 BFA (521 par
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(Continued) Faye 2003 SEN (521 part
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PCR = polymerase chain reaction PCV
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(Continued) Proportion with anaemia
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(Continued) Vivax efficacy: P. viva
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(Continued) Efficacy: Total Failure
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(Continued) Outcomes Illustrative c
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(Continued) GRADE Working Group gra
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Footnotes 1 Data were also availabl
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8 Very serious imprecision: There w
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(Continued) justed Vivax efficacy:
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(Continued) Harms: Serious adverse
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(Continued) Harms: Early vomiting -
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1 Dorsey 2006 UGA; Faye 2003 SEN; K
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