Artemisinin-based combination therapy for ... - The Cochrane Library

Analysis 2.2. Comparison 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine, Outcome 2 Total
Failure (P. falciparum) Day 42 PCR adjusted.
Review: Artemisinin-based combination therapy for treating uncomplicated malaria
Comparison: 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine
Outcome: 2 Total Failure (P. falciparum) Day 42 PCR adjusted
1 Africa
Study or subgroup DHA-P AL6 Risk Ratio Weight Risk Ratio
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI
Kamya 2006 UGA 13/130 28/117 60.4 % 0.42 [ 0.23, 0.77 ]
Yeka 2007 UGA 4/190 10/141 23.5 % 0.30 [ 0.10, 0.93 ]
Zongo 2007 BFA 4/163 7/128 16.1 % 0.45 [ 0.13, 1.50 ]
Subtotal (95% CI) 483 386 100.0 % 0.39 [ 0.24, 0.64 ]
Total events: 21 (DHA-P), 45 (AL6)
Heterogeneity: Chi 2 = 0.32, df = 2 (P = 0.85); I 2 =0.0%
Test for overall effect: Z = 3.72 (P = 0.00020)
2 Asia
Ratcliff 2005 IDN 3/179 3/138 100.0 % 0.77 [ 0.16, 3.76 ]
Subtotal (95% CI) 179 138 100.0 % 0.77 [ 0.16, 3.76 ]
Total events: 3 (DHA-P), 3 (AL6)
Heterogeneity: not applicable
Test for overall effect: Z = 0.32 (P = 0.75)
3 Oceania
Karunajeewa 2007 PNG 12/77 5/74 100.0 % 2.31 [ 0.85, 6.23 ]
Subtotal (95% CI) 77 74 100.0 % 2.31 [ 0.85, 6.23 ]
Total events: 12 (DHA-P), 5 (AL6)
Heterogeneity: not applicable
Test for overall effect: Z = 1.65 (P = 0.099)
0.01 0.1 1 10 100
Favours DHA-P Favours AL6
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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