Artemisinin-based combination therapy for ... - The Cochrane Library

Analysis 6.1. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 1 Total Failure (P.
falciparum) Day 42 PCR unadjusted. . . . . . . . . . . . . . . . . . . . . . . . . . 155
Analysis 6.2. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 2 Total Failure (P.
falciparum) Day 42 PCR adjusted. . . . . . . . . . . . . . . . . . . . . . . . . . . 156
Analysis 6.3. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 3 Total Failure (P.
falciparum) Day 28 PCR unadjusted. . . . . . . . . . . . . . . . . . . . . . . . . . 156
Analysis 6.4. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 4 Total Failure (P.
falciparum) Day 28 PCR adjusted. . . . . . . . . . . . . . . . . . . . . . . . . . . 157
Analysis 6.5. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 5 P. vivax parasitaemia. 158
Analysis 6.6. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 6 Gametocyte development
(in those negative at baseline). . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159
Analysis 6.7. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 7 Gametocyte carriage. 160
Analysis 6.8. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 8 Serious adverse events
(including deaths). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161
Analysis 6.9. Comparison 6 Artesunate plus mefloquine vs Artemether-lumefantrine, Outcome 9 Early vomiting. . 162
Analysis 7.1. Comparison 7 Artesunate plus mefloquine vs Artesunate plus amodiaquine, Outcome 1 Total Failure (P.
falciparum) Day 28 PCR unadjusted. . . . . . . . . . . . . . . . . . . . . . . . . . 162
Analysis 7.2. Comparison 7 Artesunate plus mefloquine vs Artesunate plus amodiaquine, Outcome 2 Total Failure (P.
falciparum) Day 28 PCR adjusted. . . . . . . . . . . . . . . . . . . . . . . . . . . 163
Analysis 7.3. Comparison 7 Artesunate plus mefloquine vs Artesunate plus amodiaquine, Outcome 3 Gametocyte
carriage. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
Analysis 8.1. Comparison 8 Artesunate plus mefloquine vs Amodiaquine plus sulfadoxine-pyrimethamine, Outcome 1
Total Failure (P. falciparum) Day 28 PCR unadjusted. . . . . . . . . . . . . . . . . . . . 164
Analysis 8.2. Comparison 8 Artesunate plus mefloquine vs Amodiaquine plus sulfadoxine-pyrimethamine, Outcome 2
Total Failure (P. falciparum) Day 28 PCR adjusted. . . . . . . . . . . . . . . . . . . . . 165
Analysis 8.3. Comparison 8 Artesunate plus mefloquine vs Amodiaquine plus sulfadoxine-pyrimethamine, Outcome 3
Gametocyte carriage. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165
Analysis 9.1. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 1 Total Failure (P.
falciparum) Day 28 PCR unadjusted. . . . . . . . . . . . . . . . . . . . . . . . . . 166
Analysis 9.2. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 2 Total Failure (P.
falciparum) Day 28 PCR adjusted. . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Analysis 9.3. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 3 Gametocyte
development. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168
Analysis 9.4. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 4 Gametocyte carriage. 168
Analysis 9.5. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 5 Anaemia. . . . 169
Analysis 9.6. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 6 Proportion anaemic
(Haemoglobin < 11 g/dl). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170
Analysis 9.7. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 7 Serious adverse events
(including deaths). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170
Analysis 9.8. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 8 Early vomiting. . 171
Analysis 9.9. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 9 Sensitivity analysis:
Total Failure Day 28 PCR unadjusted. . . . . . . . . . . . . . . . . . . . . . . . . . 172
Analysis 9.10. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 10 Sensitivity analysis:
Total Failure Day 28 PCR adjusted. . . . . . . . . . . . . . . . . . . . . . . . . . . 174
Analysis 10.1. Comparison 10 Artemether-lumefantrine vs Artesunate plus sulfadoxine-pyrimethamine, Outcome 1 Total
Failure (P. falciparum) Day 42 PCR unadjusted. . . . . . . . . . . . . . . . . . . . . . 176
Analysis 10.2. Comparison 10 Artemether-lumefantrine vs Artesunate plus sulfadoxine-pyrimethamine, Outcome 2 Total
Failure (P. falciparum) Day 42 PCR adjusted. . . . . . . . . . . . . . . . . . . . . . . 177
Analysis 10.3. Comparison 10 Artemether-lumefantrine vs Artesunate plus sulfadoxine-pyrimethamine, Outcome 3 Total
Failure (P. falciparum) Day 28 PCR unadjusted. . . . . . . . . . . . . . . . . . . . . . 178
Analysis 10.4. Comparison 10 Artemether-lumefantrine vs Artesunate plus sulfadoxine-pyrimethamine, Outcome 4 Total
Failure (P. falciparum) Day 28 PCR adjusted. . . . . . . . . . . . . . . . . . . . . . . 179
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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