Artemisinin-based combination therapy for ... - The Cochrane Library

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$Interventions for treating proximal humeral fractures in adults (Review)$

(... Continued) Study or subgroup AS+AQ AQ+SP Risk Ratio Risk Ratio n/N n/N M-H,Random,95% CI M-H,Random,95% CI Subtotal (95% CI) 360 161 0.01 [ 0.00, 0.23 ] Total events: 0 (AS+AQ), 16 (AQ+SP) Heterogeneity: not applicable Test for overall effect: Z = 3.00 (P = 0.0027) 3 Gametocyte carriage day 7 Faye 2003 SEN 0/360 19/161 0.01 [ 0.00, 0.19 ] Dorsey 2006 UGA 11/111 13/105 0.80 [ 0.38, 1.71 ] Menard 2006 MDG 2/80 3/80 0.67 [ 0.11, 3.88 ] Subtotal (95% CI) 551 346 0.25 [ 0.02, 2.69 ] Total events: 13 (AS+AQ), 35 (AQ+SP) Heterogeneity: Tau 2 = 3.61; Chi 2 = 12.43, df = 2 (P = 0.002); I 2 =84% Test for overall effect: Z = 1.15 (P = 0.25) 4 Gametocyte carriage day 14 Faye 2003 SEN 0/360 0/161 0.0 [ 0.0, 0.0 ] Dorsey 2006 UGA 7/109 8/105 0.84 [ 0.32, 2.24 ] Menard 2006 MDG 1/79 5/80 0.20 [ 0.02, 1.69 ] Subtotal (95% CI) 548 346 0.57 [ 0.16, 2.02 ] Total events: 8 (AS+AQ), 13 (AQ+SP) Heterogeneity: Tau 2 = 0.33; Chi 2 = 1.47, df = 1 (P = 0.23); I 2 =32% Test for overall effect: Z = 0.88 (P = 0.38) Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 0.001 0.01 0.1 1 10 100 1000 Favours ASAQ Favours AQSP 198
Analysis 13.5. Comparison 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxinepyrimethamine, Outcome 5 Anaemia. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxine-pyrimethamine Outcome: 5 Anaemia Study or subgroup AS+AQ AQ+SP Mean Difference Mean Difference 1 Mean haemoglobin (g/dl) at baseline N Mean(SD) N Mean(SD) IV,Fixed,95% CI IV,Fixed,95% CI Yeka 2004 UGA 194 9.1 (1.9) 181 8.9 (1.8) 0.20 [ -0.17, 0.57 ] Mutabingwa 2004 TZA 515 9 (1.7) 507 9 (1.7) 0.0 [ -0.21, 0.21 ] Yeka 2004 UGA 174 9.4 (1.7) 180 9.2 (1.7) 0.20 [ -0.15, 0.55 ] Yeka 2004 UGA 174 9.2 (1.9) 183 9.4 (1.9) -0.20 [ -0.59, 0.19 ] Yeka 2004 UGA 189 10.7 (2.2) 186 10.4 (2.3) 0.30 [ -0.16, 0.76 ] Dorsey 2006 UGA 232 11.5 (1.4) 253 11.6 (1.3) -0.10 [ -0.34, 0.14 ] Kayentao 2006 MLI 133 9.83 (1.8) 132 9.98 (1.59) -0.15 [ -0.56, 0.26 ] 2 Mean change in haemoglobin (g/dl) from baseline to day 14 Dorsey 2006 UGA 232 -0.03 (1.1) 253 0.16 (1.03) -0.19 [ -0.38, 0.00 ] 3 Mean change in haemoglobin (g/dl) from baseline to Day 28 Yeka 2004 UGA 174 1.44 (1.67) 180 1.44 (1.6) 0.0 [ -0.34, 0.34 ] Yeka 2004 UGA 189 0.95 (1.91) 186 1.15 (1.93) -0.20 [ -0.59, 0.19 ] Yeka 2004 UGA 194 1.14 (1.48) 181 1.58 (1.55) -0.44 [ -0.75, -0.13 ] Yeka 2004 UGA 174 1.76 (1.55) 183 1.77 (1.79) -0.01 [ -0.36, 0.34 ] Mutabingwa 2004 TZA 491 0.58 (1.4) 476 0.54 (1.4) 0.04 [ -0.14, 0.22 ] 4 Mean haemoglobin (g/dl) at Day 28 Kayentao 2006 MLI 105 10.78 (1.49) 130 11.05 (1.52) -0.27 [ -0.66, 0.12 ] Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. -0.5 -0.25 0 0.25 0.5 Favours AQSP Favours ASAQ 199
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Artemisinin-based combination thera
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Analysis 2.2. Comparison 2 Dihydroa
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Analysis 10.5. Comparison 10 Arteme
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[Intervention Review] Artemisinin-b
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B A C K G R O U N D Malaria is a di
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drugs and the treatment comparisons
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this analysis into participants who
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Figure 1. Methodological quality su
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confidence intervals of the estimat
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Anaemia Hasugian 2005 IDN found tha
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Three trials report significantly m
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or those treated for P. vivax at ba
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Early vomiting Not reported. D I S
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Figure 4. Olliaro-Vaillant plot. Da
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Figure 10. Olliaro-Vaillant plot. D
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of findings tables’. For these ta
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Huambo and Bie provinces, central A
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References to studies excluded from
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Adjuik 2004 Adjuik M, Babiker A, Ga
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C H A R A C T E R I S T I C S O F S
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Ashley 2003a THA (Continued) Outcom
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Ashley 2003b THA (Continued) Alloca
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Ashley 2005 THA (Continued) Exclusi
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Bonnet 2004 GIN (Continued) Item Au
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Bukirwa 2005 UGA Methods Trial desi
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Djimde 2004 MLI (Continued) • AS
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Dorsey 2006 UGA (Continued) Item Au
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Fanello 2004 RWA Methods Trial desi
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Faye 2003 SEN (Continued) Outcomes
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Grande 2005 PER (Continued) Allocat
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Guthmann 2004 AGO (Continued) All d
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Hasugian 2005 IDN Methods Trial des
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Hutagalung 2002 THA (Continued) 5.
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Janssens 2003 KHM (Continued) Free
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Karema 2004 RWA (Continued) Interve
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Karunajeewa 2007 PNG (Continued) Ri
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Kobbe 2007 GHA (Continued) Exclusio
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Koram 2003 GHA (Continued) Adequate
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Martensson 2003 TZA Methods Trial d
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Mayxay 2003 LAO (Continued) 1. Feve
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Menard 2006 MDG Methods Trial desig
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Mens 2007 KEN (Continued) Risk of b
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Mutabingwa 2004 TZA (Continued) •
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Owusu-Agyei 2006 GHA (Continued) Fr
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Sagara 2005b MLI (Continued) • 25
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Smithuis 2004 MMR (Continued) Risk
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Stohrer 2003 LAO Methods Trial desi
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Swarthout 2004 ZAR (Continued) Note
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Tran 2002 VNM Methods Trial design:
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Van den Broek 2003a BGD (Continued)
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Van Vugt 1998 THA Methods Trial des
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Yeka 2004 UGA (Continued) Risk of b
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Yeka 2007 UGA (Continued) Free of o
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Zongo 2007 BFA (Continued) Novartis
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(Continued) Fofana 2005 Conference
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D A T A A N D A N A L Y S E S Compa
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2.2 Asia 1 317 Risk Ratio (M-H, Fix
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Comparison 5. Dihydroartemisinin-pi
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Comparison 8. Artesunate plus meflo
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Comparison 10. Artemether-lumefantr
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Comparison 12. Artesunate plus amod
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5.2 DHA-P 3 doses 3 1116 Risk Ratio
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Comparison 21. How does Artesunate
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(... Continued) Study or subgroup D
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Analysis 1.12. Comparison 1 Dihydro
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(... Continued) Study or subgroup D
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(Continued) GRADE Working Group gra
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Footnotes 1 Data were also availabl
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8 Very serious imprecision: There w
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(Continued) Efficacy: Total Failure
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(Continued) justed Vivax efficacy:
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(Continued) Harms: Serious adverse
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(Continued) Harms: Early vomiting -
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1 Dorsey 2006 UGA; Faye 2003 SEN; K
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