Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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(... Continued)<br />
Study or subgroup AS+MQ AQ+SP Risk Ratio Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Subtotal (95% CI) 145 161 0.03 [ 0.00, 0.47 ]<br />
Total events: 0 (AS+MQ), 19 (AQ+SP)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 2.49 (P = 0.013)<br />
4 Gametocyte carriage day 14<br />
Faye 2003 SEN 0/145 0/161 0.0 [ 0.0, 0.0 ]<br />
Subtotal (95% CI) 145 161 0.0 [ 0.0, 0.0 ]<br />
Total events: 0 (AS+MQ), 0 (AQ+SP)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 0.0 (P < 0.00001)<br />
0.005 0.1 1 10 200<br />
Favours AS+MQ Favours AQ+SP<br />
Analysis 9.1. Comparison 9 Artemether-lumefantrine vs Artesunate plus amodiaquine, Outcome 1 Total<br />
Failure (P. falciparum) Day 28 PCR unadjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 9 Artemether-lumefantrine vs Artesunate plus amodiaquine<br />
Outcome: 1 Total Failure (P. falciparum) Day 28 PCR unadjusted<br />
Study or subgroup AL6 AS+AQ Risk Ratio Risk Ratio<br />
1 East Africa<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Mutabingwa 2004 TZA 103/485 193/472 0.52 [ 0.42, 0.64 ]<br />
Bukirwa 2005 UGA 102/202 133/201 0.76 [ 0.64, 0.90 ]<br />
Dorsey 2006 UGA 5/100 7/105 0.75 [ 0.25, 2.29 ]<br />
2 West Africa<br />
Faye 2003 SEN 0/147 9/349 0.12 [ 0.01, 2.12 ]<br />
Falade 2005 NGA 3/62 5/61 0.59 [ 0.15, 2.36 ]<br />
Adjei 2006 GHA 6/103 5/107 1.25 [ 0.39, 3.96 ]<br />
Owusu-Agyei 2006 GHA 42/152 22/151 1.90 [ 1.19, 3.02 ]<br />
Kobbe 2007 GHA 23/103 15/96 1.43 [ 0.79, 2.57 ]<br />
3 South/Central Africa<br />
Guthmann 2004 AGO 2/61 4/64 0.52 [ 0.10, 2.76 ]<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.005 0.1 1 10 200<br />
Favours AL6 Favours AS+AQ<br />
166