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Artemisinin-based combination therapy for ... - The Cochrane Library

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Figure 4. Olliaro-Vaillant plot. Day 28 PCR adjusted treatment failure data <strong>for</strong> trials of DHA-P against all<br />

comparators are presented in this plot.<strong>The</strong> horizontal red line represents the WHO standard of 10%<br />

treatment failure (PCR corrected). Plots below this line represent trials where DHA-P per<strong>for</strong>med to this<br />

standard.<strong>The</strong> vertical blue line represents no difference between the two drugs. Plots to the right of this line<br />

represent trials where DHA-P per<strong>for</strong>med better than the comparator drug, and plots to the left represent<br />

trials where the comparator drug per<strong>for</strong>med better than DHA-P.<br />

• AS+MQ has per<strong>for</strong>med well in trials from Asia and South<br />

America, with failure rates consistently low, but has been little<br />

studied in the African context (Figure 5; Figure 6).<br />

<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />

Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />

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