Artemisinin-based combination therapy for ... - The Cochrane Library

Analysis 3.1. Comparison 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine, Outcome 1
Total Failure (P. falciparum) Day 28 PCR unadjusted.
Review: Artemisinin-based combination therapy for treating uncomplicated malaria
Comparison: 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine
Outcome: 1 Total Failure (P. falciparum) Day 28 PCR unadjusted
Study or subgroup DHA-P AS+AQ Risk Ratio Weight Risk Ratio
1 Africa
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI
Karema 2004 RWA 24/250 45/251 82.5 % 0.54 [ 0.34, 0.85 ]
Subtotal (95% CI) 250 251 82.5 % 0.54 [ 0.34, 0.85 ]
Total events: 24 (DHA-P), 45 (AS+AQ)
Heterogeneity: not applicable
Test for overall effect: Z = 2.64 (P = 0.0082)
2 Asia
Hasugian 2005 IDN 5/94 9/84 17.5 % 0.50 [ 0.17, 1.42 ]
Subtotal (95% CI) 94 84 17.5 % 0.50 [ 0.17, 1.42 ]
Total events: 5 (DHA-P), 9 (AS+AQ)
Heterogeneity: not applicable
Test for overall effect: Z = 1.30 (P = 0.19)
Total (95% CI) 344 335 100.0 % 0.53 [ 0.35, 0.81 ]
Total events: 29 (DHA-P), 54 (AS+AQ)
Heterogeneity: Chi 2 = 0.02, df = 1 (P = 0.90); I 2 =0.0%
Test for overall effect: Z = 2.95 (P = 0.0032)
0.01 0.1 1 10 100
Favours DHA-P Favours AS+AQ
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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