Artemisinin-based combination therapy for ... - The Cochrane Library

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Analysis 12.5. Comparison 12 Artesunate plus amodiaquine vs Artesunate plus sulfadoxine-pyrimethamine, Outcome 5 Serious adverse events (including deaths). Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 12 Artesunate plus amodiaquine vs Artesunate plus sulfadoxine-pyrimethamine Outcome: 5 Serious adverse events (including deaths) Study or subgroup AS+AQ AS+SP Risk Ratio Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Hamour 2003 SDN 0/81 0/80 0.0 [ 0.0, 0.0 ] Swarthout 2004 ZAR 0/90 0/90 0.0 [ 0.0, 0.0 ] Djimde 2004 MLI 1/252 0/250 2.98 [ 0.12, 72.71 ] Kayentao 2006 MLI 0/133 1/132 0.33 [ 0.01, 8.05 ] Total (95% CI) 556 552 0.99 [ 0.14, 7.02 ] Total events: 1 (AS+AQ), 1 (AS+SP) Heterogeneity: Chi 2 = 0.91, df = 1 (P = 0.34); I 2 =0.0% Test for overall effect: Z = 0.01 (P = 0.99) Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 0.01 0.1 1 10 100 Favours ASAQ Favours ASSP 194
Analysis 13.1. Comparison 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxinepyrimethamine, Outcome 1 Total Failure (P. falciparum) Day 28 PCR unadjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 13 Artesunate plus amodiaquine vs Amodiaquine plus sulfadoxine-pyrimethamine Outcome: 1 Total Failure (P. falciparum) Day 28 PCR unadjusted Study or subgroup AS+AQ AQ+SP Risk Ratio Weight Risk Ratio 1 East Africa n/N n/N M-H,Random,95% CI M-H,Random,95% CI Staedke 2003 UGA 19/130 24/129 17.6 % 0.79 [ 0.45, 1.36 ] Karema 2004 RWA 45/251 66/255 21.2 % 0.69 [ 0.49, 0.97 ] Yeka 2004 UGA 350/706 315/701 23.9 % 1.10 [ 0.99, 1.23 ] Mutabingwa 2004 TZA 193/472 282/463 23.7 % 0.67 [ 0.59, 0.77 ] Dorsey 2006 UGA 7/105 25/105 13.6 % 0.28 [ 0.13, 0.62 ] Subtotal (95% CI) 1664 1653 100.0 % 0.72 [ 0.51, 1.01 ] Total events: 614 (AS+AQ), 712 (AQ+SP) Heterogeneity: Tau 2 = 0.11; Chi 2 = 42.74, df = 4 (P
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Artemisinin-based combination thera
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Analysis 2.2. Comparison 2 Dihydroa
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Analysis 10.5. Comparison 10 Arteme
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[Intervention Review] Artemisinin-b
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B A C K G R O U N D Malaria is a di
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drugs and the treatment comparisons
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this analysis into participants who
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Figure 1. Methodological quality su
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confidence intervals of the estimat
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Anaemia Hasugian 2005 IDN found tha
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Three trials report significantly m
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or those treated for P. vivax at ba
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Early vomiting Not reported. D I S
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Figure 4. Olliaro-Vaillant plot. Da
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Figure 10. Olliaro-Vaillant plot. D
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of findings tables’. For these ta
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Huambo and Bie provinces, central A
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References to studies excluded from
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Adjuik 2004 Adjuik M, Babiker A, Ga
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C H A R A C T E R I S T I C S O F S
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Ashley 2003a THA (Continued) Outcom
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Ashley 2003b THA (Continued) Alloca
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Ashley 2005 THA (Continued) Exclusi
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Bonnet 2004 GIN (Continued) Item Au
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Bukirwa 2005 UGA Methods Trial desi
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Djimde 2004 MLI (Continued) • AS
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Dorsey 2006 UGA (Continued) Item Au
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Fanello 2004 RWA Methods Trial desi
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Faye 2003 SEN (Continued) Outcomes
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Grande 2005 PER (Continued) Allocat
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Guthmann 2004 AGO (Continued) All d
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Hasugian 2005 IDN Methods Trial des
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Hutagalung 2002 THA (Continued) 5.
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Janssens 2003 KHM (Continued) Free
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Karema 2004 RWA (Continued) Interve
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Karunajeewa 2007 PNG (Continued) Ri
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Kobbe 2007 GHA (Continued) Exclusio
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Koram 2003 GHA (Continued) Adequate
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Martensson 2003 TZA Methods Trial d
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Mayxay 2003 LAO (Continued) 1. Feve
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Menard 2006 MDG Methods Trial desig
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Mens 2007 KEN (Continued) Risk of b
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Mutabingwa 2004 TZA (Continued) •
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Owusu-Agyei 2006 GHA (Continued) Fr
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Sagara 2005b MLI (Continued) • 25
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Smithuis 2004 MMR (Continued) Risk
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Stohrer 2003 LAO Methods Trial desi
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Swarthout 2004 ZAR (Continued) Note
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Tran 2002 VNM Methods Trial design:
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Van den Broek 2003a BGD (Continued)
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Van Vugt 1998 THA Methods Trial des
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Yeka 2004 UGA (Continued) Risk of b
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Yeka 2007 UGA (Continued) Free of o
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Zongo 2007 BFA (Continued) Novartis
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(Continued) Fofana 2005 Conference
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D A T A A N D A N A L Y S E S Compa
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2.2 Asia 1 317 Risk Ratio (M-H, Fix
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Comparison 5. Dihydroartemisinin-pi
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Comparison 8. Artesunate plus meflo
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Comparison 10. Artemether-lumefantr
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Comparison 12. Artesunate plus amod
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5.2 DHA-P 3 doses 3 1116 Risk Ratio
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Comparison 21. How does Artesunate
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(... Continued) Study or subgroup D
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Analysis 1.12. Comparison 1 Dihydro
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(... Continued) Study or subgroup D
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Page 149 and 150: Analysis 2.8. Comparison 2 Dihydroa
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(Continued) Outcomes Illustrative c
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(Continued) Efficacy: Total Failure
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(Continued) GRADE Working Group gra
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Footnotes 1 Data were also availabl
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8 Very serious imprecision: There w
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(Continued) Efficacy: Total Failure
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(Continued) justed Vivax efficacy:
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(Continued) Harms: Serious adverse
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(Continued) Harms: Early vomiting -
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1 Dorsey 2006 UGA; Faye 2003 SEN; K
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