Artemisinin-based combination therapy for ... - The Cochrane Library

Analysis 3.2. Comparison 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine, Outcome 2
Total Failure (P. falciparum) Day 28 PCR adjusted.
Review: Artemisinin-based combination therapy for treating uncomplicated malaria
Comparison: 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine
Outcome: 2 Total Failure (P. falciparum) Day 28 PCR adjusted
Study or subgroup DHA-P AS+AQ Risk Ratio Weight Risk Ratio
1 Africa
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI
Karema 2004 RWA 10/236 16/222 72.3 % 0.59 [ 0.27, 1.27 ]
Subtotal (95% CI) 236 222 72.3 % 0.59 [ 0.27, 1.27 ]
Total events: 10 (DHA-P), 16 (AS+AQ)
Heterogeneity: not applicable
Test for overall effect: Z = 1.35 (P = 0.18)
2 Asia
Hasugian 2005 IDN 1/90 6/81 27.7 % 0.15 [ 0.02, 1.22 ]
Subtotal (95% CI) 90 81 27.7 % 0.15 [ 0.02, 1.22 ]
Total events: 1 (DHA-P), 6 (AS+AQ)
Heterogeneity: not applicable
Test for overall effect: Z = 1.77 (P = 0.076)
Total (95% CI) 326 303 100.0 % 0.47 [ 0.23, 0.94 ]
Total events: 11 (DHA-P), 22 (AS+AQ)
Heterogeneity: Chi 2 = 1.47, df = 1 (P = 0.22); I 2 =32%
Test for overall effect: Z = 2.12 (P = 0.034)
0.01 0.1 1 10 100
Favours DHA-P Favours AS+AQ
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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