Artemisinin-based combination therapy for ... - The Cochrane Library

Analysis 2.3. Comparison 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine, Outcome 3 Total
Failure (P. falciparum) Day 28 PCR unadjusted.
Review: Artemisinin-based combination therapy for treating uncomplicated malaria
Comparison: 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine
Outcome: 3 Total Failure (P. falciparum) Day 28 PCR unadjusted
1 Africa
Study or subgroup DHA-P AL6 Risk Ratio Weight Risk Ratio
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI
Zongo 2007 BFA 4/172 36/178 95.9 % 0.11 [ 0.04, 0.32 ]
Mens 2007 KEN 0/67 1/67 4.1 % 0.33 [ 0.01, 8.04 ]
Subtotal (95% CI) 239 245 100.0 % 0.12 [ 0.05, 0.32 ]
Total events: 4 (DHA-P), 37 (AL6)
Heterogeneity: Chi 2 = 0.39, df = 1 (P = 0.53); I 2 =0.0%
Test for overall effect: Z = 4.27 (P = 0.000020)
2 Asia
Ratcliff 2005 IDN 6/233 13/218 100.0 % 0.43 [ 0.17, 1.12 ]
Subtotal (95% CI) 233 218 100.0 % 0.43 [ 0.17, 1.12 ]
Total events: 6 (DHA-P), 13 (AL6)
Heterogeneity: not applicable
Test for overall effect: Z = 1.73 (P = 0.083)
3 Oceania
Karunajeewa 2007 PNG 25/111 20/113 100.0 % 1.27 [ 0.75, 2.15 ]
Subtotal (95% CI) 111 113 100.0 % 1.27 [ 0.75, 2.15 ]
Total events: 25 (DHA-P), 20 (AL6)
Heterogeneity: not applicable
Test for overall effect: Z = 0.90 (P = 0.37)
0.01 0.1 1 10 100
Favours DHA-P Favours AL6
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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