Artemisinin-based combination therapy for ... - The Cochrane Library

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$Interventions for treating proximal humeral fractures in adults (Review)$

(... Continued) Study or subgroup ASAQ Control Risk Ratio Risk Ratio n/N n/N M-H,Random,95% CI M-H,Random,95% CI Bonnet 2004 GIN 1/102 1/98 0.96 [ 0.06, 15.15 ] Swarthout 2004 ZAR 5/74 13/66 0.34 [ 0.13, 0.91 ] Van den Broek 2004 ZAR 1/67 7/71 0.15 [ 0.02, 1.20 ] Djimde 2004 MLI 1/235 1/232 0.99 [ 0.06, 15.69 ] Kayentao 2006 MLI 6/79 4/122 2.32 [ 0.67, 7.95 ] Subtotal (95% CI) 691 728 0.70 [ 0.34, 1.45 ] Total events: 19 (ASAQ), 32 (Control) Heterogeneity: Tau 2 = 0.24; Chi 2 = 8.08, df = 6 (P = 0.23); I 2 =26% Test for overall effect: Z = 0.95 (P = 0.34) 5 Day 28: AS+AQ vs Amodiaquine plus sulfadoxine-pyrimethamine Faye 2003 SEN 0/340 0/154 0.0 [ 0.0, 0.0 ] Karema 2004 RWA 16/222 38/227 0.43 [ 0.25, 0.75 ] Yeka 2004 UGA 49/405 79/465 0.71 [ 0.51, 0.99 ] Dorsey 2006 UGA 2/100 16/96 0.12 [ 0.03, 0.51 ] Menard 2006 MDG 6/70 3/78 2.23 [ 0.58, 8.58 ] Kayentao 2006 MLI 6/79 1/128 9.72 [ 1.19, 79.26 ] Subtotal (95% CI) 1216 1148 0.74 [ 0.33, 1.63 ] Total events: 79 (ASAQ), 137 (Control) Heterogeneity: Tau 2 = 0.51; Chi 2 = 17.28, df = 4 (P = 0.002); I 2 =77% Test for overall effect: Z = 0.76 (P = 0.45) A P P E N D I C E S Appendix 1. Treatment comparisons eligible for review Question Analysis Comparisons 1. How does dihydroartemisinin-piperaquine perform? 1 vs artesunate plus mefloquine Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 0.005 0.1 1 10 200 Favours ASAQ Favours Control 216
(Continued) 2. How does artesunate plus mefloquine perform? 3. How does artemether-lumefantrine (6 doses) perform? 4. How does artesunate plus amodiaquine perform? Footnotes 2 vs artemether-lumefantrine (6 doses) 3 vs artesunate plus amodiaquine 4 vs artesunate plus sulfadoxine-pyrimethamine 5 vs amodiaquine plus sulfadoxine-pyrimethamine 1 vs dihydroartemisinin-piperaquine 6 vs artemether-lumefantrine (6 doses) 7 vs artesunate plus amodiaquine - vs artesunate plus sulfadoxine-pyrimethamine 8 vs amodiaquine plus sulfadoxine-pyrimethamine 2 vs dihydroartemisinin-piperaquine 6 vs artesunate plus mefloquine 9 vs artesunate plus amodiaquine 10 vs artesunate plus sulfadoxine-pyrimethamine 11 vs amodiaquine plus sulfadoxine-pyrimethamine 3 vs dihydroartemisinin-piperaquine 7 vs artesunate plus mefloquine 9 vs artemether-lumefantrine (6 doses) 12 vs artesunate plus sulfadoxine-pyrimethamine 13 vs amodiaquine plus sulfadoxine-pyrimethamine a To contribute to informed decision-making, the review is limited to artemisinin combination therapies (ACTs) for which co-formulated products are currently available or shortly to be made available (trials using co-packaged or loose preparations of these same ACTs are included). Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 217
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Artemisinin-based combination thera
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Analysis 2.2. Comparison 2 Dihydroa
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Analysis 10.5. Comparison 10 Arteme
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[Intervention Review] Artemisinin-b
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B A C K G R O U N D Malaria is a di
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drugs and the treatment comparisons
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this analysis into participants who
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Figure 1. Methodological quality su
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confidence intervals of the estimat
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Anaemia Hasugian 2005 IDN found tha
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Three trials report significantly m
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or those treated for P. vivax at ba
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Early vomiting Not reported. D I S
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Figure 4. Olliaro-Vaillant plot. Da
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Figure 10. Olliaro-Vaillant plot. D
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of findings tables’. For these ta
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Huambo and Bie provinces, central A
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References to studies excluded from
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Adjuik 2004 Adjuik M, Babiker A, Ga
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C H A R A C T E R I S T I C S O F S
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Ashley 2003a THA (Continued) Outcom
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Ashley 2003b THA (Continued) Alloca
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Ashley 2005 THA (Continued) Exclusi
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Bonnet 2004 GIN (Continued) Item Au
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Bukirwa 2005 UGA Methods Trial desi
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Djimde 2004 MLI (Continued) • AS
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Dorsey 2006 UGA (Continued) Item Au
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Fanello 2004 RWA Methods Trial desi
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Faye 2003 SEN (Continued) Outcomes
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Grande 2005 PER (Continued) Allocat
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Guthmann 2004 AGO (Continued) All d
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Hasugian 2005 IDN Methods Trial des
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Hutagalung 2002 THA (Continued) 5.
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Janssens 2003 KHM (Continued) Free
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Karema 2004 RWA (Continued) Interve
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Karunajeewa 2007 PNG (Continued) Ri
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Kobbe 2007 GHA (Continued) Exclusio
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Koram 2003 GHA (Continued) Adequate
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Martensson 2003 TZA Methods Trial d
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Mayxay 2003 LAO (Continued) 1. Feve
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Menard 2006 MDG Methods Trial desig
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Mens 2007 KEN (Continued) Risk of b
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Mutabingwa 2004 TZA (Continued) •
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Owusu-Agyei 2006 GHA (Continued) Fr
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Sagara 2005b MLI (Continued) • 25
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Smithuis 2004 MMR (Continued) Risk
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Stohrer 2003 LAO Methods Trial desi
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Swarthout 2004 ZAR (Continued) Note
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Tran 2002 VNM Methods Trial design:
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Van den Broek 2003a BGD (Continued)
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Van Vugt 1998 THA Methods Trial des
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Yeka 2004 UGA (Continued) Risk of b
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Yeka 2007 UGA (Continued) Free of o
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Zongo 2007 BFA (Continued) Novartis
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(Continued) Fofana 2005 Conference
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D A T A A N D A N A L Y S E S Compa
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2.2 Asia 1 317 Risk Ratio (M-H, Fix
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Comparison 5. Dihydroartemisinin-pi
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Comparison 8. Artesunate plus meflo
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Comparison 10. Artemether-lumefantr
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Comparison 12. Artesunate plus amod
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5.2 DHA-P 3 doses 3 1116 Risk Ratio
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Comparison 21. How does Artesunate
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(... Continued) Study or subgroup D
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Analysis 1.12. Comparison 1 Dihydro
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Analysis 6.6. Comparison 6 Artesuna
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