Artemisinin-based combination therapy for ... - The Cochrane Library

Comparison 10. Artemether-lumefantrine vs Artesunate plus sulfadoxine-pyrimethamine
Outcome or subgroup title
No. of
studies
No. of
participants Statistical method Effect size
1 Total Failure (P. falciparum) Day
42 PCR unadjusted
1 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
1.1 Oceania 1 217 Risk Ratio (M-H, Fixed, 95% CI) 0.97 [0.68, 1.36]
2 Total Failure (P. falciparum) Day
42 PCR adjusted
1 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
2.1 Oceania 1 158 Risk Ratio (M-H, Fixed, 95% CI) 0.33 [0.13, 0.86]
3 Total Failure (P. falciparum) Day
28 PCR unadjusted
2 382 Risk Ratio (M-H, Fixed, 95% CI) 0.74 [0.48, 1.16]
3.1 Africa 1 157 Risk Ratio (M-H, Fixed, 95% CI) 0.64 [0.28, 1.48]
3.2 Oceania 1 225 Risk Ratio (M-H, Fixed, 95% CI) 0.79 [0.47, 1.34]
4 Total Failure (P. falciparum) Day
28 PCR adjusted
2 345 Risk Ratio (M-H, Fixed, 95% CI) 0.53 [0.25, 1.13]
4.1 Africa 1 151 Risk Ratio (M-H, Fixed, 95% CI) 0.91 [0.34, 2.47]
4.2 Oceania 1 194 Risk Ratio (M-H, Fixed, 95% CI) 0.28 [0.08, 0.97]
5 P. vivax parasitaemia 1 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
5.1 P. vivax parasitaemia by
day 42 (P. vivax ± P. falciparum
at baseline)
1 72 Risk Ratio (M-H, Fixed, 95% CI) 1.05 [0.76, 1.43]
5.2 P. vivax parasitaemia by
day 42 (P. falciparum monoinfection
at baseline)
1 196 Risk Ratio (M-H, Fixed, 95% CI) 1.09 [0.87, 1.35]
6 Sensitivity analysis Total Failure
Day 28 PCR unadjusted
4 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
6.1 Total Failure (P. falciparum
) Day 28 PCR unadjusted
2 382 Risk Ratio (M-H, Fixed, 95% CI) 0.74 [0.48, 1.16]
6.2 Total Failure Day 28 PCR
unadjusted (trials with baseline
differences included)
4 802 Risk Ratio (M-H, Fixed, 95% CI) 0.56 [0.39, 0.79]
6.3 Total Failure Day 28 PCR
unadjusted (losses to follow up
included as failures)
2 409 Risk Ratio (M-H, Fixed, 95% CI) 0.81 [0.57, 1.17]
6.4 Total Failure Day 28 PCR
unadjusted (losses to follow up
included as successes)
2 409 Risk Ratio (M-H, Fixed, 95% CI) 0.74 [0.47, 1.15]
7 Sensitivity analysis: Total Failure
Day 28 PCR adjusted
4 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
7.1 Total Failure (P. falciparum
) Day 28 PCR adjusted
2 345 Risk Ratio (M-H, Fixed, 95% CI) 0.53 [0.25, 1.13]
7.2 Total Failure Day 28 PCR
adjusted (trials with baseline
differences included)
4 718 Risk Ratio (M-H, Fixed, 95% CI) 0.34 [0.17, 0.66]
7.3 Total Failure Day 28 PCR
adjusted (indeterminate PCR
included as failures)
2 349 Risk Ratio (M-H, Fixed, 95% CI) 0.58 [0.29, 1.16]
Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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