Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Study or subgroup AL6 AS+SP Risk Ratio Weight Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Mukhtar 2005 SDN 7/80 10/80 29.9 % 0.70 [ 0.28, 1.75 ]<br />
Karunajeewa 2007 PNG 19/127 23/122 70.1 % 0.79 [ 0.46, 1.38 ]<br />
Subtotal (95% CI) 207 202 100.0 % 0.77 [ 0.48, 1.23 ]<br />
Total events: 26 (AL6), 33 (AS+SP)<br />
Heterogeneity: Chi 2 = 0.05, df = 1 (P = 0.82); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 1.10 (P = 0.27)<br />
6 Total Failure Day 28 PCR adjusted (losses to follow up included as successes)<br />
Mukhtar 2005 SDN 7/80 7/80 34.5 % 1.00 [ 0.37, 2.72 ]<br />
Karunajeewa 2007 PNG 5/127 13/122 65.5 % 0.37 [ 0.14, 1.01 ]<br />
Subtotal (95% CI) 207 202 100.0 % 0.59 [ 0.30, 1.17 ]<br />
Total events: 12 (AL6), 20 (AS+SP)<br />
Heterogeneity: Chi 2 = 1.91, df = 1 (P = 0.17); I 2 =48%<br />
Test <strong>for</strong> overall effect: Z = 1.52 (P = 0.13)<br />
0.005 0.1 1 10 200<br />
Favours AL6 Favours AS+SP<br />
Analysis 11.1. Comparison 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine,<br />
Outcome 1 Total Failure (P. falciparum) Day 28 PCR unadjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 1 Total Failure (P. falciparum) Day 28 PCR unadjusted<br />
Study or subgroup AL6 AQ+SP Risk Ratio Weight Risk Ratio<br />
1 East Africa<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Fanello 2004 RWA 36/246 89/247 22.1 % 0.41 [ 0.29, 0.57 ]<br />
Mutabingwa 2004 TZA 103/485 282/463 71.8 % 0.35 [ 0.29, 0.42 ]<br />
Dorsey 2006 UGA 5/100 25/105 6.1 % 0.21 [ 0.08, 0.53 ]<br />
Subtotal (95% CI) 831 815 100.0 % 0.35 [ 0.30, 0.41 ]<br />
Total events: 144 (AL6), 396 (AQ+SP)<br />
Heterogeneity: Chi 2 = 1.88, df = 2 (P = 0.39); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 12.61 (P < 0.00001)<br />
2 West Africa<br />
0.01 0.1 1 10 100<br />
Favours AL6 Favours AQ+SP<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
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