Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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1.5 Day 28: DHA-P vs<br />
Amodiaquine plus sulfadoxinepyrimethamine<br />
Comparison 19. How does Artesunate plus mefloquine per<strong>for</strong>m?<br />
Outcome or subgroup title<br />
1 Effectiveness: Total Failure (P.<br />
falciparum) PCR adjusted<br />
1.1 Day 63: AS+MQ<br />
vs Dihydroartemisininpiperaquine<br />
1.2 Day 42: AS+MQ vs<br />
Artemether-lumefantrine<br />
1.3 Day 28: AS+MQ vs<br />
Artesunate plus amodiaquine<br />
1.4 Day 28: AS+MQ vs<br />
Artesunate plus sulfadoxinepyrimethamine<br />
1.5 Day 28: AS+MQ vs<br />
Amodiaquine plus sulfadoxinepyrimethamine<br />
2 802 Risk Ratio (M-H, Random, 95% CI) 0.32 [0.16, 0.64]<br />
No. of<br />
studies<br />
Comparison 20. How does Artemether-lumefantrine per<strong>for</strong>m?<br />
Outcome or subgroup title<br />
1 Effectiveness: Total Failure (P.<br />
falciparum) Day PCR adjusted<br />
1.1 Day 42: AL vs<br />
Dihydroartemisininpiperaquine<br />
1.2 Day 42: AL vs Artesunate<br />
plus mefloquine<br />
1.3 Day 28: AL vs Artesunate<br />
plus amodiaquine<br />
1.4 Day 42: AL vs<br />
Artesunate plus sulfadoxinepyrimethamine<br />
1.5 Day 28: AL vs<br />
Amodiaquine plus sulfadoxinepyrimethamine<br />
No. of<br />
participants Statistical method Effect size<br />
9 Risk Ratio (M-H, Random, 95% CI) Subtotals only<br />
4 1497 Risk Ratio (M-H, Random, 95% CI) 1.77 [0.55, 5.72]<br />
4 904 Risk Ratio (M-H, Random, 95% CI) 0.38 [0.05, 2.84]<br />
1 482 Risk Ratio (M-H, Random, 95% CI) Not estimable<br />
0 0 Risk Ratio (M-H, Random, 95% CI) Not estimable<br />
1 296 Risk Ratio (M-H, Random, 95% CI) Not estimable<br />
No. of<br />
studies<br />
No. of<br />
participants Statistical method Effect size<br />
19 Risk Ratio (M-H, Random, 95% CI) Subtotals only<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
5 1337 Risk Ratio (M-H, Random, 95% CI) 1.61 [0.77, 3.39]<br />
4 904 Risk Ratio (M-H, Random, 95% CI) 2.66 [0.35, 20.09]<br />
8 1729 Risk Ratio (M-H, Random, 95% CI) 1.71 [0.97, 3.02]<br />
1 158 Risk Ratio (M-H, Random, 95% CI) 0.33 [0.13, 0.86]<br />
5 1669 Risk Ratio (M-H, Random, 95% CI) 0.40 [0.08, 2.11]<br />
122