Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 8.2. Comparison 8 Artesunate plus mefloquine vs Amodiaquine plus sulfadoxine-pyrimethamine,<br />
Outcome 2 Total Failure (P. falciparum) Day 28 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 8 Artesunate plus mefloquine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 2 Total Failure (P. falciparum) Day 28 PCR adjusted<br />
Study or subgroup AS+MQ AQ+SP Risk Ratio Risk Ratio<br />
1 Africa<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/142 0/154 0.0 [ 0.0, 0.0 ]<br />
0.02 0.1 1 10 50<br />
Favours AS+MQ Favours AQ+SP<br />
Analysis 8.3. Comparison 8 Artesunate plus mefloquine vs Amodiaquine plus sulfadoxine-pyrimethamine,<br />
Outcome 3 Gametocyte carriage.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 8 Artesunate plus mefloquine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 3 Gametocyte carriage<br />
Study or subgroup AS+MQ AQ+SP Risk Ratio Risk Ratio<br />
1 Gametocyte carriage day 0<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/145 5/161 0.10 [ 0.01, 1.81 ]<br />
Subtotal (95% CI) 145 161 0.10 [ 0.01, 1.81 ]<br />
Total events: 0 (AS+MQ), 5 (AQ+SP)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 1.56 (P = 0.12)<br />
2 Gametocyte carriage day 3<br />
Faye 2003 SEN 3/145 16/161 0.21 [ 0.06, 0.70 ]<br />
Subtotal (95% CI) 145 161 0.21 [ 0.06, 0.70 ]<br />
Total events: 3 (AS+MQ), 16 (AQ+SP)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 2.54 (P = 0.011)<br />
3 Gametocyte carriage day 7<br />
Faye 2003 SEN 0/145 19/161 0.03 [ 0.00, 0.47 ]<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.005 0.1 1 10 200<br />
Favours AS+MQ Favours AQ+SP<br />
(Continued ...)<br />
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