Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 3.6. Comparison 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine, Outcome 6<br />
Serious adverse events (including deaths).<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine<br />
Outcome: 6 Serious adverse events (including deaths)<br />
Study or subgroup DHA-P AS+AQ Risk Ratio Weight Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Hasugian 2005 IDN 0/168 3/166 100.0 % 0.14 [ 0.01, 2.71 ]<br />
Total (95% CI) 168 166 100.0 % 0.14 [ 0.01, 2.71 ]<br />
Total events: 0 (DHA-P), 3 (AS+AQ)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 1.30 (P = 0.19)<br />
0.005 0.1 1 10 200<br />
Favours DHA-P Favours AS+AQ<br />
Analysis 3.7. Comparison 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine, Outcome 7<br />
Early vomiting.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 3 Dihydroartemisinin-piperaquine vs Artesunate plus amodiaquine<br />
Outcome: 7 Early vomiting<br />
Study or subgroup DHA-P AS+AQ Risk Ratio Weight Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Hasugian 2005 IDN 7/168 13/166 100.0 % 0.53 [ 0.22, 1.30 ]<br />
Total (95% CI) 168 166 100.0 % 0.53 [ 0.22, 1.30 ]<br />
Total events: 7 (DHA-P), 13 (AS+AQ)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 1.38 (P = 0.17)<br />
0.01 0.1 1 10 100<br />
Favours DHA-P Favours AS+AQ<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
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