Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 1.3. Comparison 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine, Outcome 3<br />
Total Failure (P. falciparum) Day 42 PCR unadjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine<br />
Outcome: 3 Total Failure (P. falciparum) Day 42 PCR unadjusted<br />
Study or subgroup DHA-P AS+MQ Risk Ratio Weight Risk Ratio<br />
1 Asia<br />
n/N n/N M-H,Random,95% CI M-H,Random,95% CI<br />
Tran 2002 VNM 16/166 7/77 24.2 % 1.06 [ 0.45, 2.47 ]<br />
Janssens 2003 KHM 9/195 9/207 22.9 % 1.06 [ 0.43, 2.62 ]<br />
Mayxay 2004 LAO 4/106 5/108 15.7 % 0.82 [ 0.23, 2.95 ]<br />
Smithuis 2004 MMR 6/319 1/316 7.7 % 5.94 [ 0.72, 49.09 ]<br />
Ashley 2004 THA 16/318 19/157 29.5 % 0.42 [ 0.22, 0.79 ]<br />
0.01 0.1 1 10 100<br />
Favours DHA-P Favours AS+MQ<br />
Analysis 1.4. Comparison 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine, Outcome 4<br />
Total Failure (P. falciparum) Day 42 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine<br />
Outcome: 4 Total Failure (P. falciparum) Day 42 PCR adjusted<br />
Study or subgroup DHA-P AS+MQ Risk Ratio Weight Risk Ratio<br />
1 Asia<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Tran 2002 VNM 2/152 1/71 9.5 % 0.93 [ 0.09, 10.13 ]<br />
Janssens 2003 KHM 3/189 2/200 13.6 % 1.59 [ 0.27, 9.39 ]<br />
Smithuis 2004 MMR 2/315 0/315 3.5 % 5.00 [ 0.24, 103.73 ]<br />
Ashley 2004 THA 2/304 7/145 66.4 % 0.14 [ 0.03, 0.65 ]<br />
Mayxay 2004 LAO 1/103 1/104 7.0 % 1.01 [ 0.06, 15.93 ]<br />
0.002 0.1 1 10 500<br />
Favours DHA-P Favours AS+MQ<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
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