Artemisinin-based combination therapy for ... - The Cochrane Library

More documents

Recommendations

Info

$Interventions for treating proximal humeral fractures in adults (Review)$

Analysis 15.1. Comparison 15 Dihydroartemisinin-piperaquine dose analysis (versus Artesunate plus mefloquine), Outcome 1 Total Failure Day 63 PCR unadjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 15 Dihydroartemisinin-piperaquine dose analysis (versus Artesunate plus mefloquine) Outcome: 1 Total Failure Day 63 PCR unadjusted Study or subgroup DHA-P ASMQ Risk Ratio Weight Risk Ratio 1 DHA-P 4 doses n/N n/N M-H,Random,95% CI M-H,Random,95% CI Ashley 2003b THA 26/154 29/151 24.9 % 0.88 [ 0.54, 1.42 ] Ashley 2004 THA 18/155 27/157 23.2 % 0.68 [ 0.39, 1.17 ] Janssens 2003 KHM 18/195 22/207 22.4 % 0.87 [ 0.48, 1.57 ] Subtotal (95% CI) 504 515 70.5 % 0.81 [ 0.59, 1.10 ] Total events: 62 (DHA-P), 78 (ASMQ) Heterogeneity: Tau 2 = 0.0; Chi 2 = 0.58, df = 2 (P = 0.75); I 2 =0.0% Test for overall effect: Z = 1.36 (P = 0.17) 2 DHA-P 3 doses Ashley 2004 THA 11/163 27/157 20.7 % 0.39 [ 0.20, 0.76 ] Grande 2005 PER 12/219 2/226 8.7 % 6.19 [ 1.40, 27.35 ] Subtotal (95% CI) 382 383 29.5 % 1.44 [ 0.09, 22.81 ] Total events: 23 (DHA-P), 29 (ASMQ) Heterogeneity: Tau 2 = 3.64; Chi 2 = 11.56, df = 1 (P = 0.00067); I 2 =91% Test for overall effect: Z = 0.26 (P = 0.80) Total (95% CI) 886 898 100.0 % 0.83 [ 0.49, 1.38 ] Total events: 85 (DHA-P), 107 (ASMQ) Heterogeneity: Tau 2 = 0.22; Chi 2 = 12.26, df = 4 (P = 0.02); I 2 =67% Test for overall effect: Z = 0.72 (P = 0.47) 0.01 0.1 1 10 100 Favours DHA-P Favours ASMQ Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 202
Analysis 15.2. Comparison 15 Dihydroartemisinin-piperaquine dose analysis (versus Artesunate plus mefloquine), Outcome 2 Total Failure Day 63 PCR adjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 15 Dihydroartemisinin-piperaquine dose analysis (versus Artesunate plus mefloquine) Outcome: 2 Total Failure Day 63 PCR adjusted Study or subgroup DHA-P ASMQ Risk Ratio Weight Risk Ratio 1 DHA-P 4 doses n/N n/N M-H,Random,95% CI M-H,Random,95% CI Ashley 2003b THA 3/131 9/131 26.6 % 0.33 [ 0.09, 1.20 ] Ashley 2004 THA 1/138 7/137 15.5 % 0.14 [ 0.02, 1.14 ] Janssens 2003 KHM 4/181 5/190 26.4 % 0.84 [ 0.23, 3.08 ] Subtotal (95% CI) 450 458 68.5 % 0.42 [ 0.17, 1.04 ] Total events: 8 (DHA-P), 21 (ASMQ) Heterogeneity: Tau 2 = 0.09; Chi 2 = 2.31, df = 2 (P = 0.31); I 2 =13% Test for overall effect: Z = 1.88 (P = 0.060) 2 DHA-P 3 doses Ashley 2004 THA 2/154 7/137 22.1 % 0.25 [ 0.05, 1.20 ] Grande 2005 PER 4/211 0/224 9.4 % 9.55 [ 0.52, 176.35 ] Subtotal (95% CI) 365 361 31.5 % 1.27 [ 0.03, 48.28 ] Total events: 6 (DHA-P), 7 (ASMQ) Heterogeneity: Tau 2 = 5.56; Chi 2 = 4.91, df = 1 (P = 0.03); I 2 =80% Test for overall effect: Z = 0.13 (P = 0.90) Total (95% CI) 815 819 100.0 % 0.48 [ 0.18, 1.31 ] Total events: 14 (DHA-P), 28 (ASMQ) Heterogeneity: Tau 2 = 0.54; Chi 2 = 7.08, df = 4 (P = 0.13); I 2 =44% Test for overall effect: Z = 1.44 (P = 0.15) 0.005 0.1 1 10 200 Favours DHA-P Favours ASMQ Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 203
Page 1 and 2:
Artemisinin-based combination thera
Page 3 and 4:
Analysis 2.2. Comparison 2 Dihydroa
Page 5 and 6:
Analysis 10.5. Comparison 10 Arteme
Page 7 and 8:
[Intervention Review] Artemisinin-b
Page 9 and 10:
B A C K G R O U N D Malaria is a di
Page 11 and 12:
drugs and the treatment comparisons
Page 13 and 14:
this analysis into participants who
Page 15 and 16:
Figure 1. Methodological quality su
Page 17 and 18:
confidence intervals of the estimat
Page 19 and 20:
Anaemia Hasugian 2005 IDN found tha
Page 21 and 22:
Three trials report significantly m
Page 23 and 24:
or those treated for P. vivax at ba
Page 25 and 26:
Early vomiting Not reported. D I S
Page 27 and 28:
Figure 4. Olliaro-Vaillant plot. Da
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Figure 10. Olliaro-Vaillant plot. D
Page 35 and 36:
of findings tables’. For these ta
Page 37 and 38:
Huambo and Bie provinces, central A
Page 39 and 40:
References to studies excluded from
Page 41 and 42:
Adjuik 2004 Adjuik M, Babiker A, Ga
Page 43 and 44:
C H A R A C T E R I S T I C S O F S
Page 45 and 46:
Ashley 2003a THA (Continued) Outcom
Page 47 and 48:
Ashley 2003b THA (Continued) Alloca
Page 49 and 50:
Ashley 2005 THA (Continued) Exclusi
Page 51 and 52:
Bonnet 2004 GIN (Continued) Item Au
Page 53 and 54:
Bukirwa 2005 UGA Methods Trial desi
Page 55 and 56:
Djimde 2004 MLI (Continued) • AS
Page 57 and 58:
Dorsey 2006 UGA (Continued) Item Au
Page 59 and 60:
Fanello 2004 RWA Methods Trial desi
Page 61 and 62:
Faye 2003 SEN (Continued) Outcomes
Page 63 and 64:
Grande 2005 PER (Continued) Allocat
Page 65 and 66:
Guthmann 2004 AGO (Continued) All d
Page 67 and 68:
Hasugian 2005 IDN Methods Trial des
Page 69 and 70:
Hutagalung 2002 THA (Continued) 5.
Page 71 and 72:
Janssens 2003 KHM (Continued) Free
Page 73 and 74:
Karema 2004 RWA (Continued) Interve
Page 75 and 76:
Karunajeewa 2007 PNG (Continued) Ri
Page 77 and 78:
Kobbe 2007 GHA (Continued) Exclusio
Page 79 and 80:
Koram 2003 GHA (Continued) Adequate
Page 81 and 82:
Martensson 2003 TZA Methods Trial d
Page 83 and 84:
Mayxay 2003 LAO (Continued) 1. Feve
Page 85 and 86:
Menard 2006 MDG Methods Trial desig
Page 87 and 88:
Mens 2007 KEN (Continued) Risk of b
Page 89 and 90:
Mutabingwa 2004 TZA (Continued) •
Page 91 and 92:
Owusu-Agyei 2006 GHA (Continued) Fr
Page 93 and 94:
Sagara 2005b MLI (Continued) • 25
Page 95 and 96:
Smithuis 2004 MMR (Continued) Risk
Page 97 and 98:
Stohrer 2003 LAO Methods Trial desi
Page 99 and 100:
Swarthout 2004 ZAR (Continued) Note
Page 101 and 102:
Tran 2002 VNM Methods Trial design:
Page 103 and 104:
Van den Broek 2003a BGD (Continued)
Page 105 and 106:
Van Vugt 1998 THA Methods Trial des
Page 107 and 108:
Yeka 2004 UGA (Continued) Risk of b
Page 109 and 110:
Yeka 2007 UGA (Continued) Free of o
Page 111 and 112:
Zongo 2007 BFA (Continued) Novartis
Page 113 and 114:
(Continued) Fofana 2005 Conference
Page 115 and 116:
D A T A A N D A N A L Y S E S Compa
Page 117 and 118:
2.2 Asia 1 317 Risk Ratio (M-H, Fix
Page 119 and 120:
Comparison 5. Dihydroartemisinin-pi
Page 121 and 122:
Comparison 8. Artesunate plus meflo
Page 123 and 124:
Comparison 10. Artemether-lumefantr
Page 125 and 126:
Comparison 12. Artesunate plus amod
Page 127 and 128:
5.2 DHA-P 3 doses 3 1116 Risk Ratio
Page 129 and 130:
Comparison 21. How does Artesunate
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
(... Continued) Study or subgroup D
Page 139 and 140:
Analysis 1.12. Comparison 1 Dihydro
Page 141 and 142:
(... Continued) Study or subgroup D
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158: Analysis 4.5. Comparison 4 Dihydroa
Page 163 and 164: (... Continued) Study or subgroup A
Page 165 and 166: Analysis 6.6. Comparison 6 Artesuna
Page 173 and 174: Analysis 9.2. Comparison 9 Artemeth
Page 177 and 178: Analysis 9.8. Comparison 9 Artemeth
Page 183 and 184: Analysis 10.2. Comparison 10 Arteme
Page 197 and 198: Analysis 12.2. Comparison 12 Artesu
Page 207: Analysis 14.2. Comparison 14 Dihydr
Page 211 and 212: Analysis 15.4. Comparison 15 Dihydr
Page 213 and 214: Analysis 15.6. Comparison 15 Dihydr
Page 217 and 218: (... Continued) Study or subgroup D
Page 219 and 220: Analysis 20.1. Comparison 20 How do
Page 221 and 222: Analysis 21.1. Comparison 21 How do
Page 223 and 224: (Continued) 2. How does artesunate
Page 225 and 226: (Continued) Sensitivity analysis 1
Page 227 and 228: (Continued) Smithuis 2004 MMR (652
Page 229 and 230: Dihydroartemisinin-piperaquine vs A
Page 231 and 232: (Continued) Mayxay 2003 LAO (220 pa
Page 233 and 234: Artesunate plus mefloquine vs Amodi
Page 235 and 236: (Continued) Faye 2003 SEN (509 part
Page 237 and 238: Artemether-lumefantrine vs Artesuna
Page 239 and 240: (Continued) Zongo 2005 BFA (521 par
Page 241 and 242: (Continued) Faye 2003 SEN (521 part
Page 243 and 244: PCR = polymerase chain reaction PCV
Page 245 and 246: (Continued) Proportion with anaemia
Page 247 and 248: (Continued) Vivax efficacy: P. viva
Page 249 and 250: (Continued) Efficacy: Total Failure
Page 251 and 252: (Continued) Outcomes Illustrative c
Page 253 and 254: (Continued) Efficacy: Total Failure
Page 255 and 256: (Continued) GRADE Working Group gra
Page 257 and 258: Footnotes 1 Data were also availabl
Page 259 and 260:
8 Very serious imprecision: There w
Page 261 and 262:
(Continued) Efficacy: Total Failure
Page 263 and 264:
(Continued) justed Vivax efficacy:
Page 265 and 266:
(Continued) Harms: Serious adverse
Page 267 and 268:
(Continued) Harms: Early vomiting -
Page 269 and 270:
1 Dorsey 2006 UGA; Faye 2003 SEN; K
show all

Artemisinin-based combination therapy for ... - The Cochrane Library

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?