Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 7.2. Comparison 7 Artesunate plus mefloquine vs Artesunate plus amodiaquine, Outcome 2 Total<br />
Failure (P. falciparum) Day 28 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 7 Artesunate plus mefloquine vs Artesunate plus amodiaquine<br />
Outcome: 2 Total Failure (P. falciparum) Day 28 PCR adjusted<br />
Study or subgroup AS+MQ AS+AQ Risk Ratio Risk Ratio<br />
1 Africa<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/142 0/340 0.0 [ 0.0, 0.0 ]<br />
0.01 0.1 1 10 100<br />
Favours AS+MQ Favours AS+AQ<br />
Analysis 7.3. Comparison 7 Artesunate plus mefloquine vs Artesunate plus amodiaquine, Outcome 3<br />
Gametocyte carriage.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 7 Artesunate plus mefloquine vs Artesunate plus amodiaquine<br />
Outcome: 3 Gametocyte carriage<br />
Study or subgroup AS+MQ AS+AQ Risk Ratio Risk Ratio<br />
1 Gametocyte carriage day 0<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/145 0/360 0.0 [ 0.0, 0.0 ]<br />
Subtotal (95% CI) 145 360 0.0 [ 0.0, 0.0 ]<br />
Total events: 0 (AS+MQ), 0 (AS+AQ)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 0.0 (P < 0.00001)<br />
2 Gametocyte carriage day 3<br />
Faye 2003 SEN 3/145 0/360 17.31 [ 0.90, 332.99 ]<br />
Subtotal (95% CI) 145 360 17.31 [ 0.90, 332.99 ]<br />
Total events: 3 (AS+MQ), 0 (AS+AQ)<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 1.89 (P = 0.059)<br />
3 Gametocyte carriage day 7<br />
Faye 2003 SEN 0/145 0/360 0.0 [ 0.0, 0.0 ]<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.005 0.1 1 10 200<br />
Favours AS+MQ Favours AS+AQ<br />
(Continued ...)<br />
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