Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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(... Continued)<br />
Study or subgroup ASAQ Control Risk Ratio Risk Ratio<br />
n/N n/N M-H,Random,95% CI M-H,Random,95% CI<br />
Bonnet 2004 GIN 1/102 1/98 0.96 [ 0.06, 15.15 ]<br />
Swarthout 2004 ZAR 5/74 13/66 0.34 [ 0.13, 0.91 ]<br />
Van den Broek 2004 ZAR 1/67 7/71 0.15 [ 0.02, 1.20 ]<br />
Djimde 2004 MLI 1/235 1/232 0.99 [ 0.06, 15.69 ]<br />
Kayentao 2006 MLI 6/79 4/122 2.32 [ 0.67, 7.95 ]<br />
Subtotal (95% CI) 691 728 0.70 [ 0.34, 1.45 ]<br />
Total events: 19 (ASAQ), 32 (Control)<br />
Heterogeneity: Tau 2 = 0.24; Chi 2 = 8.08, df = 6 (P = 0.23); I 2 =26%<br />
Test <strong>for</strong> overall effect: Z = 0.95 (P = 0.34)<br />
5 Day 28: AS+AQ vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Faye 2003 SEN 0/340 0/154 0.0 [ 0.0, 0.0 ]<br />
Karema 2004 RWA 16/222 38/227 0.43 [ 0.25, 0.75 ]<br />
Yeka 2004 UGA 49/405 79/465 0.71 [ 0.51, 0.99 ]<br />
Dorsey 2006 UGA 2/100 16/96 0.12 [ 0.03, 0.51 ]<br />
Menard 2006 MDG 6/70 3/78 2.23 [ 0.58, 8.58 ]<br />
Kayentao 2006 MLI 6/79 1/128 9.72 [ 1.19, 79.26 ]<br />
Subtotal (95% CI) 1216 1148 0.74 [ 0.33, 1.63 ]<br />
Total events: 79 (ASAQ), 137 (Control)<br />
Heterogeneity: Tau 2 = 0.51; Chi 2 = 17.28, df = 4 (P = 0.002); I 2 =77%<br />
Test <strong>for</strong> overall effect: Z = 0.76 (P = 0.45)<br />
A P P E N D I C E S<br />
Appendix 1. Treatment comparisons eligible <strong>for</strong> review<br />
Question Analysis Comparisons<br />
1. How does dihydroartemisinin-piperaquine<br />
per<strong>for</strong>m?<br />
1 vs artesunate plus mefloquine<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.005 0.1 1 10 200<br />
Favours ASAQ Favours Control<br />
216