Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 1.5. Comparison 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine, Outcome 5<br />
Total Failure (P. falciparum) Day 28 PCR unadjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine<br />
Outcome: 5 Total Failure (P. falciparum) Day 28 PCR unadjusted<br />
1 Asia<br />
Study or subgroup DHA-P AS+MQ Risk Ratio Risk Ratio<br />
n/N n/N M-H,Random,95% CI M-H,Random,95% CI<br />
Tran 2002 VNM 0/166 0/77 0.0 [ 0.0, 0.0 ]<br />
Janssens 2003 KHM 2/195 2/207 1.06 [ 0.15, 7.46 ]<br />
Ashley 2003a THA 1/59 0/59 3.00 [ 0.12, 72.18 ]<br />
Ashley 2004 THA 5/318 13/157 0.19 [ 0.07, 0.52 ]<br />
Smithuis 2004 MMR 6/319 0/316 12.88 [ 0.73, 227.64 ]<br />
Tangpukdee 2005 THA 1/107 0/54 1.53 [ 0.06, 36.89 ]<br />
0.005 0.1 1 10 200<br />
Favours DHA-P Favours AS+MQ<br />
Analysis 1.6. Comparison 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine, Outcome 6<br />
Total Failure (P. falciparum) Day 28 PCR adjusted.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine<br />
Outcome: 6 Total Failure (P. falciparum) Day 28 PCR adjusted<br />
1 Asia<br />
Study or subgroup DHA-P AS+MQ Risk Ratio Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Tran 2002 VNM 0/166 0/77 0.0 [ 0.0, 0.0 ]<br />
Janssens 2003 KHM 2/195 1/206 2.11 [ 0.19, 23.11 ]<br />
Ashley 2003a THA 1/59 0/59 3.00 [ 0.12, 72.18 ]<br />
Ashley 2004 THA 2/315 7/151 0.14 [ 0.03, 0.65 ]<br />
Smithuis 2004 MMR 2/315 0/316 5.02 [ 0.24, 104.06 ]<br />
Tangpukdee 2005 THA 1/107 0/54 1.53 [ 0.06, 36.89 ]<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.002 0.1 1 10 500<br />
Favours DHA-P Favours AS+MQ<br />
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