Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 2.8. Comparison 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine, Outcome 8<br />
Serious adverse events (including deaths).<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine<br />
Outcome: 8 Serious adverse events (including deaths)<br />
Study or subgroup DHA-P AL6 Risk Ratio Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Ratcliff 2005 IDN 1/379 2/375 0.49 [ 0.05, 5.43 ]<br />
Kamya 2006 UGA 4/211 2/210 1.99 [ 0.37, 10.75 ]<br />
Yeka 2007 UGA 5/215 2/199 2.31 [ 0.45, 11.79 ]<br />
Zongo 2007 BFA 0/187 0/188 0.0 [ 0.0, 0.0 ]<br />
Mens 2007 KEN 1/73 0/73 3.00 [ 0.12, 72.45 ]<br />
Total (95% CI) 1065 1045 1.71 [ 0.66, 4.46 ]<br />
Total events: 11 (DHA-P), 6 (AL6)<br />
Heterogeneity: Chi 2 = 1.31, df = 3 (P = 0.73); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 1.10 (P = 0.27)<br />
0.01 0.1 1 10 100<br />
Favours DHA-P Favours AL6<br />
Analysis 2.9. Comparison 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine, Outcome 9 Early<br />
vomiting.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 2 Dihydroartemisinin-piperaquine vs Artemether-lumefantrine<br />
Outcome: 9 Early vomiting<br />
Study or subgroup DHA-P AL6 Risk Ratio Weight Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Ratcliff 2005 IDN 11/379 10/375 77.1 % 1.09 [ 0.47, 2.53 ]<br />
Zongo 2007 BFA 7/196 3/197 22.9 % 2.35 [ 0.62, 8.94 ]<br />
Total (95% CI) 575 572 100.0 % 1.38 [ 0.68, 2.78 ]<br />
Total events: 18 (DHA-P), 13 (AL6)<br />
Heterogeneity: Chi 2 = 0.91, df = 1 (P = 0.34); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 0.89 (P = 0.37)<br />
0.01 0.1 1 10 100<br />
Favours DHA-P Favours AL6<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
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