Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 11.7. Comparison 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine,<br />
Outcome 7 Anaemia.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 7 Anaemia<br />
Study or subgroup AL6 AQ+SP Mean Difference Mean Difference<br />
1 Mean haemoglobin (g/dl) at baseline<br />
N Mean(SD) N Mean(SD) IV,Fixed,95% CI IV,Fixed,95% CI<br />
Zongo 2005 BFA 261 9.3 (2.3) 260 9.9 (2.3) -0.60 [ -0.99, -0.21 ]<br />
Zongo 2007 BFA 188 10.2 (2) 184 10.3 (2.3) -0.10 [ -0.54, 0.34 ]<br />
2 Mean change in haemoglobin (g/dl) from baseline to Day 28<br />
Zongo 2005 BFA 261 1.18 (0.19) 260 1.01 (0.2) 0.17 [ 0.14, 0.20 ]<br />
3 Mean haemoglobin (g/dl) at Day 42 or last day of follow up.<br />
Zongo 2007 BFA 188 11.3 (1.6) 184 11.8 (1.4) -0.50 [ -0.81, -0.19 ]<br />
-1 -0.5 0 0.5 1<br />
Favours AS+AQ Favours AL6<br />
Analysis 11.8. Comparison 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine,<br />
Outcome 8 Serious adverse events (including deaths).<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 11 Artemether-lumefantrine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 8 Serious adverse events (including deaths)<br />
Study or subgroup AL6 AQ+SP Risk Ratio Risk Ratio<br />
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI<br />
Faye 2003 SEN 0/149 0/161 0.0 [ 0.0, 0.0 ]<br />
Mutabingwa 2004 TZA 1/519 1/507 0.98 [ 0.06, 15.58 ]<br />
Zongo 2005 BFA 1/261 1/260 1.00 [ 0.06, 15.84 ]<br />
Dorsey 2006 UGA 14/202 16/253 1.10 [ 0.55, 2.19 ]<br />
Zongo 2007 BFA 0/188 0/184 0.0 [ 0.0, 0.0 ]<br />
Total (95% CI) 1319 1365 1.08 [ 0.56, 2.08 ]<br />
Total events: 16 (AL6), 18 (AQ+SP)<br />
Heterogeneity: Chi 2 = 0.01, df = 2 (P = 1.00); I 2 =0.0%<br />
Test <strong>for</strong> overall effect: Z = 0.24 (P = 0.81)<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
0.01 0.1 1 10 100<br />
Favours AL6 Favours AQ+SP<br />
188