Artemisinin-based combination therapy for ... - The Cochrane Library

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Analysis 16.1. Comparison 16 Artesunate Mefloquine dose analysis: FDC versus split dose regimen, Outcome 1 Total Failure Day 63 PCR unadjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 16 Artesunate Mefloquine dose analysis: FDC versus split dose regimen Outcome: 1 Total Failure Day 63 PCR unadjusted Study or subgroup ASMQ FDC ASMQ Loose Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Ashley 2005 THA 55/212 59/211 100.0 % 0.93 [ 0.68, 1.27 ] Total (95% CI) 212 211 100.0 % 0.93 [ 0.68, 1.27 ] Total events: 55 (ASMQ FDC), 59 (ASMQ Loose) Heterogeneity: not applicable Test for overall effect: Z = 0.47 (P = 0.64) 0.01 0.1 1 10 100 Favours ASMQ FDC Favours ASMQ Loose Analysis 16.2. Comparison 16 Artesunate Mefloquine dose analysis: FDC versus split dose regimen, Outcome 2 Total Failure Day 63 PCR adjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 16 Artesunate Mefloquine dose analysis: FDC versus split dose regimen Outcome: 2 Total Failure Day 63 PCR adjusted Study or subgroup ASMQ FDC ASMQ Loose Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Ashley 2005 THA 13/170 20/172 100.0 % 0.66 [ 0.34, 1.28 ] Total (95% CI) 170 172 100.0 % 0.66 [ 0.34, 1.28 ] Total events: 13 (ASMQ FDC), 20 (ASMQ Loose) Heterogeneity: not applicable Test for overall effect: Z = 1.23 (P = 0.22) 0.01 0.1 1 10 100 Favours ASMQ FDC Favours ASMQ Loose Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 208
Analysis 17.1. Comparison 17 Artesunate plus mefloquine dose analysis (versus Dihydroartemisininpiperaquine), Outcome 1 Total Failure Day 63 PCR adjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 17 Artesunate plus mefloquine dose analysis (versus Dihydroartemisinin-piperaquine) Outcome: 1 Total Failure Day 63 PCR adjusted Study or subgroup ASMQ 8mg/kg/day DHA-P Risk Ratio Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Ashley 2003b THA 9/131 3/131 3.00 [ 0.83, 10.83 ] Ashley 2004 THA 7/137 3/292 4.97 [ 1.31, 18.94 ] Grande 2005 PER 0/224 4/211 0.10 [ 0.01, 1.93 ] 0.005 0.1 1 10 200 Favours ASMQ Favours DHA-P Analysis 17.2. Comparison 17 Artesunate plus mefloquine dose analysis (versus Dihydroartemisininpiperaquine), Outcome 2 Total Failure Day 28 PCR adjusted. Review: Artemisinin-based combination therapy for treating uncomplicated malaria Comparison: 17 Artesunate plus mefloquine dose analysis (versus Dihydroartemisinin-piperaquine) Outcome: 2 Total Failure Day 28 PCR adjusted Study or subgroup ASMQ 8mg/kg/day DHA-P Risk Ratio Weight Risk Ratio n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI Ashley 2003a THA 1/59 0/59 43.0 % 3.00 [ 0.12, 72.18 ] Tangpukdee 2005 THA 1/107 0/54 57.0 % 1.53 [ 0.06, 36.89 ] Total (95% CI) 166 113 100.0 % 2.16 [ 0.23, 19.88 ] Total events: 2 (ASMQ 8mg/kg/day), 0 (DHA-P) Heterogeneity: Chi 2 = 0.09, df = 1 (P = 0.77); I 2 =0.0% Test for overall effect: Z = 0.68 (P = 0.50) 0.01 0.1 1 10 100 Favours ASMQ Favours DHA-P Artemisinin-based combination therapy for treating uncomplicated malaria (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 209
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Artemisinin-based combination thera
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Analysis 2.2. Comparison 2 Dihydroa
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Analysis 10.5. Comparison 10 Arteme
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[Intervention Review] Artemisinin-b
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B A C K G R O U N D Malaria is a di
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drugs and the treatment comparisons
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this analysis into participants who
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Figure 1. Methodological quality su
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confidence intervals of the estimat
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Anaemia Hasugian 2005 IDN found tha
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Three trials report significantly m
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or those treated for P. vivax at ba
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Early vomiting Not reported. D I S
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Figure 4. Olliaro-Vaillant plot. Da
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Figure 10. Olliaro-Vaillant plot. D
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of findings tables’. For these ta
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Huambo and Bie provinces, central A
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References to studies excluded from
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Adjuik 2004 Adjuik M, Babiker A, Ga
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C H A R A C T E R I S T I C S O F S
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Ashley 2003a THA (Continued) Outcom
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Ashley 2003b THA (Continued) Alloca
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Ashley 2005 THA (Continued) Exclusi
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Bonnet 2004 GIN (Continued) Item Au
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Bukirwa 2005 UGA Methods Trial desi
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Djimde 2004 MLI (Continued) • AS
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Dorsey 2006 UGA (Continued) Item Au
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Fanello 2004 RWA Methods Trial desi
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Faye 2003 SEN (Continued) Outcomes
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Grande 2005 PER (Continued) Allocat
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Guthmann 2004 AGO (Continued) All d
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Hasugian 2005 IDN Methods Trial des
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Hutagalung 2002 THA (Continued) 5.
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Janssens 2003 KHM (Continued) Free
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Karema 2004 RWA (Continued) Interve
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Karunajeewa 2007 PNG (Continued) Ri
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Kobbe 2007 GHA (Continued) Exclusio
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Koram 2003 GHA (Continued) Adequate
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Martensson 2003 TZA Methods Trial d
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Mayxay 2003 LAO (Continued) 1. Feve
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Menard 2006 MDG Methods Trial desig
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Mens 2007 KEN (Continued) Risk of b
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Mutabingwa 2004 TZA (Continued) •
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Owusu-Agyei 2006 GHA (Continued) Fr
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Sagara 2005b MLI (Continued) • 25
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Smithuis 2004 MMR (Continued) Risk
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Stohrer 2003 LAO Methods Trial desi
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Swarthout 2004 ZAR (Continued) Note
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Tran 2002 VNM Methods Trial design:
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Van den Broek 2003a BGD (Continued)
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Van Vugt 1998 THA Methods Trial des
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Yeka 2004 UGA (Continued) Risk of b
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Yeka 2007 UGA (Continued) Free of o
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Zongo 2007 BFA (Continued) Novartis
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(Continued) Fofana 2005 Conference
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D A T A A N D A N A L Y S E S Compa
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2.2 Asia 1 317 Risk Ratio (M-H, Fix
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Comparison 5. Dihydroartemisinin-pi
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Comparison 8. Artesunate plus meflo
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Comparison 10. Artemether-lumefantr
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Comparison 12. Artesunate plus amod
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5.2 DHA-P 3 doses 3 1116 Risk Ratio
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Comparison 21. How does Artesunate
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(... Continued) Study or subgroup D
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Analysis 1.12. Comparison 1 Dihydro
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(... Continued) Study or subgroup D
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Page 243 and 244: PCR = polymerase chain reaction PCV
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(Continued) Harms: Serious adverse
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(Continued) Harms: Early vomiting -
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1 Dorsey 2006 UGA; Faye 2003 SEN; K
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