Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
Artemisinin-based combination therapy for ... - The Cochrane Library
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Analysis 5.6. Comparison 5 Dihydroartemisinin-piperaquine vs Amodiaquine plus sulfadoxinepyrimethamine,<br />
Outcome 6 Anaemia.<br />
Review: <strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria<br />
Comparison: 5 Dihydroartemisinin-piperaquine vs Amodiaquine plus sulfadoxine-pyrimethamine<br />
Outcome: 6 Anaemia<br />
Study or subgroup DHA-P AQ+SP Mean Difference Weight Mean Difference<br />
1 Mean haemoglobin (g/dl) at baseline<br />
N Mean(SD) N Mean(SD) IV,Fixed,95% CI IV,Fixed,95% CI<br />
Zongo 2007 BFA 187 10.1 (2.4) 184 10.3 (2.3) 100.0 % -0.20 [ -0.68, 0.28 ]<br />
Subtotal (95% CI) 187 184 100.0 % -0.20 [ -0.68, 0.28 ]<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 0.82 (P = 0.41)<br />
2 Mean haemoglobin (g/dl) at day 42 or last day of follow up<br />
Zongo 2007 BFA 187 11.6 (1.6) 184 11.8 (1.4) 100.0 % -0.20 [ -0.51, 0.11 ]<br />
Subtotal (95% CI) 187 184 100.0 % -0.20 [ -0.51, 0.11 ]<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 1.28 (P = 0.20)<br />
3 Mean packed cell volume at baseline<br />
Karema 2004 RWA 252 31.5 (4.9) 258 31.5 (5.3) 100.0 % 0.0 [ -0.89, 0.89 ]<br />
Subtotal (95% CI) 252 258 100.0 % 0.0 [ -0.89, 0.89 ]<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 0.0 (P = 1.0)<br />
4 Mean packed cell volume at day 14<br />
Karema 2004 RWA 252 33.4 (3.6) 258 34.5 (3.7) 100.0 % -1.10 [ -1.73, -0.47 ]<br />
Subtotal (95% CI) 252 258 100.0 % -1.10 [ -1.73, -0.47 ]<br />
Heterogeneity: not applicable<br />
Test <strong>for</strong> overall effect: Z = 3.40 (P = 0.00067)<br />
Test <strong>for</strong> subgroup differences: Chi 2 = 7.14, df = 3 (P = 0.07), I 2 =58%<br />
<strong>Artemisinin</strong>-<strong>based</strong> <strong>combination</strong> <strong>therapy</strong> <strong>for</strong> treating uncomplicated malaria (Review)<br />
Copyright © 2009 <strong>The</strong> <strong>Cochrane</strong> Collaboration. Published by John Wiley & Sons, Ltd.<br />
-2 -1 0 1 2<br />
Favours AQ+SP Favours DHA-P<br />
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